Browsing Research Articles (Nuclear Medicine) by Title

Browsing Research Articles (Nuclear Medicine) by Title

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  • PSMA theranostics : science and practice 
    Mokoala, K.M.G. (Kgomotso); Lawal, Ismaheel Opeyemi; Lengana, Thabo; Kgatle, Mankgopo; Giesel, Frederik L.; Vorster, Mariza; Sathekge, Mike Machaba (MDPI, 2021-08-02)
    Prostate cancer (PCa) causes significant morbidity and mortality in men globally. While localized PCa may be managed with curative intent by surgery and/or radiation therapy, the management of advanced hormone resistant ...
  • PSMA-targeting positron emission agents for imaging solid tumors other than non-prostate carcinoma : a systematic review 
    Van de Wiele, Christophe; Sathekge, Mike Machaba; De Spiegeleer, Bart; De Jonghe, Pieter Jan; Beels, Laurence; Maes, Alex (MDPI Publishing, 2019-10-02)
    Despite its name, prostate-specific membrane antigen (PSMA) has been shown using immunohistochemistry (IHC) to also be over-expressed in the tumor neovasculature of a wide variety of solid tumors other than prostate ...
  • Quantitative chest X-ray radiomics for therapy response monitoring in patients with pulmonary tuberculosis 
    Du Plessis, Tamarisk; Rae, William Ian Duncombe; Ramkilawon, Gopika; Ramkilawon, Gopika Devi; Martinson, Neil Alexander; Sathekge, Mike Machaba (MDPI, 2023-09-01)
    Tuberculosis (TB) remains the second leading cause of death globally from a single infectious agent, and there is a critical need to develop improved imaging biomarkers and aid rapid assessments of responses to therapy. ...
  • The quorum sensing peptides PhrG, CSP and EDP promote angiogenesis and invasion of breast cancer cells in vitro 
    De Spiegeleer, Bart; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Van de Wiele, Christophe; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; Wynendaele, Evelien (Public Library of Science, 2015-03-17)
    The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated the influence of some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, on ...
  • Radionuclide imaging of invasive fungal disease in immunocompromised hosts 
    Lawal, Ismaheel Opeyemi; Mokoala, K.M.G. (Kgomotso); Kgatle, Mankgopo; Dierckx, Rudi A.J.O.; Glaudemans, Andor W.J.M.; Sathekge, Mike Machaba; Ankrah, Alfred O. (MDPI, 2021-11-06)
    Invasive fungal disease (IFD) leads to increased mortality, morbidity, and costs of treatment in patients with immunosuppressive conditions. The definitive diagnosis of IFD relies on the isolation of the causative fungal ...
  • Radiopharmaceutical enhancement by drug delivery systems : a review 
    Kleynhans, Janke; Grobler, Anne Frederica; Ebenhan, Thomas; Sathekge, Mike Machaba; Zeevaart, Jan-Rijn (Elsevier, 2018-10)
    INTRODUCTION : Drug delivery systems are entities designed to alter the biological behaviour of the pharmaceutical active ingredients that they carry in order to afford more beneficial biodistribution and safety profiles. ...
  • Renal osteodystrophy presenting as a metabolic superscan on F-18 FDG PET/CT : a case report 
    Lawal, Ismaheel Opeyemi; Ankrah, Alfred O.; Ololade, Kehinde O.; Modiselle, Moshe; Sathekge, Mike Machaba (Wolters Kluwer Health, Inc., 2017-11)
    RATIONALE : F-18 Fluoro Deoxyglucose positron emission tomography and computed tomography (F-18 FDG PET/CT) is a useful modality in the evaluation of patients with malignancies. Increased incidence of lympho-proliferative ...
  • Role of FDG PET/CT in monitoring treatment response in patients with invasive fungal infections 
    Ankrah, Alfred O.; Span, Lambert F.R.; Klein, Hans C.; De Jong, Pim A.; Dierckx, Rudi A.J.O.; Kwee, Thomas C.; Sathekge, Mike Machaba; Glaudemans, Andor W.J.M. (Springer, 2019-01)
    INTRODUCTION : Invasive fungal infections (IFIs) occur mostly in immunosuppressed patients and can be life-threatening. Inadequate treatment is associated with high morbidity and mortality. We examined the role of ...
  • The role of PET in monitoring therapy in fungal infections 
    Ankrah, Alfred O.; Klein, Hans C.; Span, Lambert F.R.; De Vries, Erik F.J.; Dierckx, Rudi A.J.O.; Sathekge, Mike Machaba; Glaudemans, Andor W.J.M. (Bentham Science, 2018)
    Positron emission tomography (PET) is a powerful diagnostic nuclear medicine imaging technique. PET allows in vivo detection of a wide variety of physiologic and pathologic phenomena and it offers a noninvasive tool for ...
  • Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles 
    Mandiwana, Vusani; Kalombo, Lonji; Venter, Kobus; Sathekge, Mike Machaba; Grobler, Anne; Zeevaart, Jan Rijn (Springer, 2015-09)
    Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim ...
  • The scintigraphic evaluation of the pulmonary perfusion pattern of dogs hospitalised with babesiosis 
    Sweers, L.; Kirberger, Robert M.; Leisewitz, Andrew L.; Dormehl, I.C.; Killian, E.; Naude, F. (South African Veterinary Association, 2008-06)
    The possibility of coagulopathy in Babesia canis rossi infections in the canine patient has been suggested in the literature, but minimal work has been done to evaluate the clinicopathological nature of it in further detail. ...
  • Second generation Al18F-labeled D-amino acid peptide for CXCR4 targeted molecular imaging 
    Spahn, Muriel Aline; Luyten, Kaat; Van Loy, Tom; Sathekge, Mike Machaba; Deroose, Christophe M.; Koole, Michel; Schols, Dominique; Vanduffel, Wim; De Vos, Kristof; Annaert, Pieter; Bormans, Guy; Cleeren, Frederik (Elsevier, 2024-05)
    Please read abstract in the article.
  • Serum tumor markers and PET/CT imaging for tumor recurrence detection 
    Kruse, Vibeke; Cocquyt, Veronique; Borms, Marleen; Maes, Alex; Van de Wiele, Christophe (Springer, 2013-02)
    When confronted with a suspicious rise in CA 15.3 in asymptomatic breast cancer patients following primary treatment and negative or equivocal conventional imaging findings, FDG PET/CT allows assessment of the site and ...
  • Single photon emission tomography in the diagnostic assessment of cardiac and vascular infectious diseases 
    Lawal, Ismaheel Opeyemi; Kleyhans, Janke; Mokoala, K.M.G. (Kgomotso); Vorster, Mariza; Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (Bentham Science, 2021)
    Please read abstract in the article
  • South African guidelines for receptor radioligand therapy (RLT) with Lu-177-PSMA in prostate cancer 
    Vorster, Mariza; Warwick, J.; Lawal, Ismaheel Opeyemi; Du Toit, P.; Vangu, M.; Nyakale, N.E.; Steyn, R.; Gutta, A.A.; Hart, G.; Mutambirwa, S.; Ellmann, A.; Sathekge, Mike Machaba (South African Medical Association, 2019-12)
    BACKGROUND : Prostate cancer is an important cause of morbidity and mortality in South Africa, as it is in the rest of the world. In African men, however, prostate cancer tends to follow a more aggressive course when ...
  • Spotlight : the status of radiopharmacy in Africa 
    Kleynhans, Janke; Summers, Beverly; Sakr, Tamer; Zeevaart, Jan Rijn; Lundie, Maryke; Du Plessis, Samantha; Mosima, Lerato; Bentaleb, Naoual; Ekoume, Fany P.; Hlongwa, Khanyisile N.; Shambel, Seble; Mldophane, Amanda; Mangatha, Amreeta; More, Stuart (Springer, 2024-04)
    No abstract available.
  • A study investigating variability of left ventricular ejection fraction using manual and automatic processing modes in a single setting 
    Bresser, Philppa Lynn; De Beer, Janeske; De Wet, Yolandi (Elsevier, 2015-02)
    PURPOSE : A planar multi-gated cardiac blood pool acquisition is a non-invasive technique commonly used to measure left ventricular ejection fraction (LVEF). It is essential that the calculation of LVEF be accurate, ...
  • A study of technetium-99m wastage in selected private sector nuclear medicine imaging departments 
    Mathurine, Germaine; Bresser, Philppa Lynn; Teixeira, Nadia (Lippincott Williams & Wilkins, 2013-12)
    BACKGROUND : South African nuclear medicine imaging departments have been fortunate in being able to receive an uninterrupted supply of molybdenum-99 (99Mo)/technetium-99m (99mTc) generators. Nuclear medicine radiographers ...
  • Synthesis, 68Ga-radiolabeling, and preliminary in vivo assessment of a depsipeptide-derived compound as a potential PET/CT infection imaging agent 
    Mokaleng, Botshelo B.; Ebenhan, Thomas; Ramesh, Suhas; Govender, Thavendran; Kruger, Hendrik G.; Parboosing, Raveen; Hazari, Puja P.; Mishra, Anil K.; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (Hindawi Publishing, 2015)
    Noninvasive imaging is a powerful tool for early diagnosis and monitoring of various disease processes, such as infections. An alarming shortage of infection-selective radiopharmaceuticals exists for overcoming the diagnostic ...
  • Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection 
    Dutta, Jyotibon; Baijnath, Sooraj; Somboro, Anou M.; Nagiah, Savania; Albericio, Fernando; De la Torre, Beatriz G.; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Kruger, Hendrik G.; Chuturgoon, Anil; Naicker, Tricia; Ebenhan, Thomas; Govender, Thavendran (Wiley, 2017-10)
    Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the ...