Dutta, Jyotibon; Baijnath, Sooraj; Somboro, Anou M.; Nagiah, Savania; Albericio, Fernando; De la Torre, Beatriz G.; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Kruger, Hendrik G.; Chuturgoon, Anil; Naicker, Tricia; Ebenhan, Thomas; Govender, Thavendran(Wiley, 2017-10)
Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the ...
Sathekge, Mike Machaba; Lengana, Thabo; Maes, Alex; Vorster, Mariza; Zeevaart, Jan Rijn; Lawal, Ismaheel; Ebenhan, Thomas; Van de Wiele, Christophe(Springer, 2018-02)
PURPOSE : The incidence of prostate cancer is 60% higher and
the mortality rate is two- to three-times greater in black versus
white men. We report on differences in 68Ga-PSMA-11 PET/CT imaging findings in 77 black ...
Prostate-specific membrane antigen radioligand therapy
(PSMA-RLT) with 177Lu-PSMA holds great promise as a
safe treatment option in patients with metastasized
castration-resistant prostate cancer (mCRPC) with ...
Sathekge, Mike Machaba; Lengana, Thabo; Modiselle, Moshe; Vorster, Mariza; Zeevaart, Jan Rijn; Maes, Alex; Ebenhan, Thomas; Van de Wiele, Christophe(Springer, 2017-04)
BACKGROUND : To report on imaging findings using 68Ga-PSMAHBED-
CC PET in a series of 19 breast carcinoma patients.
METHODS : 68Ga-PSMA-HBED-CC PET imaging results obtained
were compared to routinely performed staging ...
Ebenhan, Thomas; Mokaleng, Botshelo B.; Venter, Jacobus Daniel; Kruger, Hendrik Gert; Zeevaart, Jan Rijn; Sathekge, Mike Machaba(MDPI Publishing, 2017-09)
The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its
potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled
DOTA-TBIA101 imaging was performed ...
Sathekge, Mike Machaba(Health and Medical Publishing Group, 2017-09)
In the recent Transactions, the Colleges of Medicine of South Africa
(CMSA) states that work-based assessment (WBA) should be
an essential part of an assessment system, alongside the national
professional examination. ...
Bracke, Nathalie; Yao, Han; Wynendaele, Evelien; Verbeke, Frederick; Xu, Xiaolong; Gevaert, Bert; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Saeger, Sarah; De Spiegeleer, Bart(American Chemical Society, 2017-03)
Chemical modifications on protein biopharmaceuticals introduce extra variability in addition to their inherent complexity, hence require more comprehensive analytical and functional characterization during their discovery, ...
Dutta, Jyotibon; Naicker, Tricia; Ebenhan, Thomas; Kruger, Hendrik G.; Arvidsson, Per I.; Govender, Thavendran(Elsevier, 2017-06)
This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes fortomographic imaging. These molecular probes encompass leukocytes, ...
Ebenhan, Thomas; Schoeman, Isabel; Rossouw, Daniel D.; Grobler, Anne; Marjanovic-Painter, Biljana; Wagener, Judith; Kruger, Hendrik G.; Sathekge, Mike Machaba; Zeevaart, Jan Rijn(Springer, 2017-06)
PURPOSE : Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating ...
Bracke, Nathalie; Wynendaele, Evelien; D’Hondt, Matthias; Haselberg, Rob; Somsen, Govert W.; Pauwels, Ewald; Van de Wiele, Christophe; De Spiegeleer, Bart(Elsevier, 2014-08)
Chemical modification of biomolecules like the introduction of metal-chelators into proteins can lead
to heterogeneous product formation. The nature and extend of the modification is important in
interpreting the biological ...
Wynendaele, Evelien; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Van de Wiele, Christophe; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; De Spiegeleer, Bart(Elsevier, 2015-02)
To date, the precise role of the human microbiome in health and disease states remains largely
undefined. Complex and selective crosstalk systems between the microbiome and mammalian
cells are also not yet reported. ...
Mandiwana, Vusani; Kalombo, Lonji; Venter, Kobus; Sathekge, Mike Machaba; Grobler, Anne; Zeevaart, Jan Rijn(Springer, 2015-09)
Developing nanoparticulate delivery systems
that will allow easy movement and localization
of a drug to the target tissue and provide more
controlled release of the drug in vivo is a challenge in
nanomedicine. The aim ...
De Spiegeleer, Bart; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Van de Wiele, Christophe; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; Wynendaele, Evelien(Public Library of Science, 2015-03-17)
The role of the human microbiome on cancer progression remains unclear. Therefore, in
this study, we investigated the influence of some quorum sensing peptides, produced by diverse
commensal or pathogenic bacteria, on ...
Ankrah, Alfred O.; Glaudemans, Andor W.J.M.; Sathekge, Mike Machaba; Klein, Hans C.(SpringerOpen, 2016-04)
In a previous paper, an overview of the use of PET/CT in
the management of tuberculosis (TB) was provided and the
potential role of nitroimidazole imaging in LTBI was
considered . During latent TB, dormant bacilli ...
Lawal, Ismaheel; Vorster, Mariza; Boshomane, Tebatso; Ololade, Kehinde; Ebenhan, Thomas; Sathekge, Mike Machaba(Lippincott Williams and Wilkins, 2015-09)
We describe the finding of a metastatic superscan detected by Ga-PSMA PET/CT imaging. A 63-year-old man with metastatic prostate carcinoma underwent Ga-PSMA PET/CT imaging for staging and evaluation of the most appropriate ...
Vorster, Mariza; Doruyter, A.; Brink, A.; Mkhize, S.; Holness, J.; Malan, N.; Nyakale, Nozipho E.; Warwick, J.M.; Sathekge, Mike Machaba(Health and Medical Publishing Group, 2016-01)
These recommendations are intended to serve an important and relevant role in advising referring physicians on the appropriate use
of 18F-fluorodeoxyglucose (18F-FDG) and non-18F-FDG positron emission tomography/computed ...
Buscombe, J.R. (John Richard)(British Institute of Radiology, 2015)
Positron emission tomography (PET) has become widely established in oncology. Subsequently, a whole new “toolbox” of
tracers have become available to look at different aspects of cancer cell function and dysfunction, ...
Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly
expressed in almost all prostate cancers. By playing such a universal role in the disease,
PSMA provides a target for diagnostic imaging of ...
Mokaleng, Botshelo B.; Ebenhan, Thomas; Ramesh, Suhas; Govender, Thavendran; Kruger, Hendrik G.; Parboosing, Raveen; Hazari, Puja P.; Mishra, Anil K.; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn; Sathekge, Mike Machaba(Hindawi Publishing, 2015)
Noninvasive imaging is a powerful tool for early diagnosis and monitoring of various disease processes, such as infections. An alarming shortage of infection-selective radiopharmaceuticals exists for overcoming the diagnostic ...