Nuclear Medicine

Nuclear Medicine

Recent Submissions

  • Tack, Liesa; Bracke, Nathalie; Verbeke, Frederick; Wynendaele, Evelien; Pauwels, Ewald; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Spiegeleer, Bart (Springer, 2018-08)
    Little is known about possible cryptic peptides of the recombinant growth hormone (somatropin). In this study, six synthetic somatropin-derived peptides (SDPs) were selected based on their sequences which correspond to the ...
  • Kleynhans, Janke; Grobler, Anne Frederica; Ebenhan, Thomas; Sathekge, Mike Machaba; Zeevaart, Jan-Rijn (Elsevier, 2018-10)
    INTRODUCTION : Drug delivery systems are entities designed to alter the biological behaviour of the pharmaceutical active ingredients that they carry in order to afford more beneficial biodistribution and safety profiles. ...
  • Ankrah, Alfred O.; Klein, Hans C.; Elsinga, Philip H. (Bentham Science, 2018)
    Diabetic Foot Infections (DFIs) are associated with increased morbidity, an economic burden on patients, their families and healthcare systems and increased mortality. Early diagnosis with prompt, appropriate and adequate ...
  • Pfannkuchen, Nina; Meckel, Marian; Bergmann, Ralf; Bachmann, Michael; Bal, Chandrasekhar; Sathekge, Mike Machaba; Mohnike, Wolfgang; Baum, Richard P.; Rosch, Frank (MDPI Publishing, 2017-05-18)
    Bone metastases, often a consequence of breast, prostate, and lung carcinomas, are characterized by an increased bone turnover, which can be visualized by positron emission tomography (PET), as well as single-photon ...
  • Reyneke, Florette; Mokgoro, N.P. (Neo); Vorster, Mariza; Sathekge, Mike Machaba (Lippincott, Williams and Wilkins, 2017)
    RATIONALE : Burkitt lymphoma (BL) is a type of non-Hodgkin lymphoma that arises in the B-cells. Cavernous sinus involvement is rare, especially in adults. Here we report an unusual case of a 30-year-old HIV-positive woman ...
  • Lawal, Ismaheel; Ankrah, Alfred O.; Ololade, Kehinde; Modiselle, Moshe; Sathekge, Mike Machaba (Wolters Kluwer Health, Inc., 2017-11)
    RATIONALE : F-18 Fluoro Deoxyglucose positron emission tomography and computed tomography (F-18 FDG PET/CT) is a useful modality in the evaluation of patients with malignancies. Increased incidence of lympho-proliferative ...
  • Dutta, Jyotibon; Baijnath, Sooraj; Somboro, Anou M.; Nagiah, Savania; Albericio, Fernando; De la Torre, Beatriz G.; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Kruger, Hendrik G.; Chuturgoon, Anil; Naicker, Tricia; Ebenhan, Thomas; Govender, Thavendran (Wiley, 2017-10)
    Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the ...
  • Sathekge, Mike Machaba; Lengana, Thabo; Maes, Alex; Vorster, Mariza; Zeevaart, Jan Rijn; Lawal, Ismaheel; Ebenhan, Thomas; Van de Wiele, Christophe (Springer, 2018-02)
    PURPOSE : The incidence of prostate cancer is 60% higher and the mortality rate is two- to three-times greater in black versus white men. We report on differences in 68Ga-PSMA-11 PET/CT imaging findings in 77 black ...
  • Sathekge, Mike Machaba; Knoesen, Otto; Meckel, Marian; Modiselle, Moshe; Vorster, Mariza; Marx, Sebastian (Springer, 2017-06)
    Prostate-specific membrane antigen radioligand therapy (PSMA-RLT) with 177Lu-PSMA holds great promise as a safe treatment option in patients with metastasized castration-resistant prostate cancer (mCRPC) with ...
  • Sathekge, Mike Machaba; Lengana, Thabo; Modiselle, Moshe; Vorster, Mariza; Zeevaart, Jan Rijn; Maes, Alex; Ebenhan, Thomas; Van de Wiele, Christophe (Springer, 2017-04)
    BACKGROUND : To report on imaging findings using 68Ga-PSMAHBED- CC PET in a series of 19 breast carcinoma patients. METHODS : 68Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging ...
  • Venter, Edna K.; Lange, Greta; Kruger, Christa; Meyer, Bernard J. (Health and Medical Publishing Group, 2002-12)
    No abstract available.
  • Ebenhan, Thomas; Mokaleng, Botshelo B.; Venter, Jacobus Daniel; Kruger, Hendrik Gert; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI Publishing, 2017-09)
    The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed ...
  • Sathekge, Mike Machaba (Health and Medical Publishing Group, 2017-09)
    In the recent Transactions, the Colleges of Medicine of South Africa (CMSA) states that work-based assessment (WBA) should be an essential part of an assessment system, alongside the national professional examination. ...
  • Bracke, Nathalie; Yao, Han; Wynendaele, Evelien; Verbeke, Frederick; Xu, Xiaolong; Gevaert, Bert; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Saeger, Sarah; De Spiegeleer, Bart (American Chemical Society, 2017-03)
    Chemical modifications on protein biopharmaceuticals introduce extra variability in addition to their inherent complexity, hence require more comprehensive analytical and functional characterization during their discovery, ...
  • Dutta, Jyotibon; Naicker, Tricia; Ebenhan, Thomas; Kruger, Hendrik G.; Arvidsson, Per I.; Govender, Thavendran (Elsevier, 2017-06)
    This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes fortomographic imaging. These molecular probes encompass leukocytes, ...
  • Ebenhan, Thomas; Schoeman, Isabel; Rossouw, Daniel D.; Grobler, Anne; Marjanovic-Painter, Biljana; Wagener, Judith; Kruger, Hendrik G.; Sathekge, Mike Machaba; Zeevaart, Jan Rijn (Springer, 2017-06)
    PURPOSE : Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating ...
  • Bracke, Nathalie; Wynendaele, Evelien; D’Hondt, Matthias; Haselberg, Rob; Somsen, Govert W.; Pauwels, Ewald; Van de Wiele, Christophe; De Spiegeleer, Bart (Elsevier, 2014-08)
    Chemical modification of biomolecules like the introduction of metal-chelators into proteins can lead to heterogeneous product formation. The nature and extend of the modification is important in interpreting the biological ...
  • Wynendaele, Evelien; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Van de Wiele, Christophe; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; De Spiegeleer, Bart (Elsevier, 2015-02)
    To date, the precise role of the human microbiome in health and disease states remains largely undefined. Complex and selective crosstalk systems between the microbiome and mammalian cells are also not yet reported. ...
  • Mandiwana, Vusani; Kalombo, Lonji; Venter, Kobus; Sathekge, Mike Machaba; Grobler, Anne; Zeevaart, Jan Rijn (Springer, 2015-09)
    Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim ...
  • De Spiegeleer, Bart; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Van de Wiele, Christophe; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; Wynendaele, Evelien (Public Library of Science, 2015-03-17)
    The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated the influence of some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, on ...

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