The quorum sensing peptides PhrG, CSP and EDP promote angiogenesis and invasion of breast cancer cells in vitro
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Date
Authors
De Spiegeleer, Bart
Verbeke, Frederick
D’Hondt, Matthias
Hendrix, An
Van de Wiele, Christophe
Burvenich, Christian
Peremans, Kathelijne
De Wever, Olivier
Bracke, Marc
Wynendaele, Evelien
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Abstract
The role of the human microbiome on cancer progression remains unclear. Therefore, in
this study, we investigated the influence of some quorum sensing peptides, produced by diverse
commensal or pathogenic bacteria, on breast cancer cell invasion and thus cancer
outcome. Based on microscopy, transcriptome and Chick Chorioallantoic Membrane
(CAM) analyses, four peptides (PhrG from B. subtilis, CSP from S. mitis and EDF from
E. coli, together with its tripeptide analogue) were found to promote tumour cell invasion
and angiogenesis, thereby potentially influencing tumour metastasis. Our results offer not
only new insights on the possible role of the microbiome, but also further opportunities in
cancer prevention and therapy by competing with these endogenous molecules and/or by
modifying people’s life style.
Description
S1 Table. List of quorum sensing peptides, repeatedly (n = 3) investigated for their effect
on tumour cell invasion (Collagen Type 1 invasion assay).
Keywords
Human microbiome, Therapy, Prevention, Breast cancer
Sustainable Development Goals
Citation
De Spiegeleer B, Verbeke F, D’Hondt M,
Hendrix A, Van De Wiele C, Burvenich C, et al.
(2015) The Quorum Sensing Peptides PhrG, CSP
and EDF Promote Angiogenesis and Invasion of
Breast Cancer Cells In Vitro. PLoS ONE 10(3):
e0119471. DOI: 10.1371/journal.pone.0119471.