The quorum sensing peptides PhrG, CSP and EDP promote angiogenesis and invasion of breast cancer cells in vitro

Loading...
Thumbnail Image

Authors

De Spiegeleer, Bart
Verbeke, Frederick
D’Hondt, Matthias
Hendrix, An
Van de Wiele, Christophe
Burvenich, Christian
Peremans, Kathelijne
De Wever, Olivier
Bracke, Marc
Wynendaele, Evelien

Journal Title

Journal ISSN

Volume Title

Publisher

Public Library of Science

Abstract

The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated the influence of some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, on breast cancer cell invasion and thus cancer outcome. Based on microscopy, transcriptome and Chick Chorioallantoic Membrane (CAM) analyses, four peptides (PhrG from B. subtilis, CSP from S. mitis and EDF from E. coli, together with its tripeptide analogue) were found to promote tumour cell invasion and angiogenesis, thereby potentially influencing tumour metastasis. Our results offer not only new insights on the possible role of the microbiome, but also further opportunities in cancer prevention and therapy by competing with these endogenous molecules and/or by modifying people’s life style.

Description

S1 Table. List of quorum sensing peptides, repeatedly (n = 3) investigated for their effect on tumour cell invasion (Collagen Type 1 invasion assay).

Keywords

Human microbiome, Therapy, Prevention, Breast cancer

Sustainable Development Goals

Citation

De Spiegeleer B, Verbeke F, D’Hondt M, Hendrix A, Van De Wiele C, Burvenich C, et al. (2015) The Quorum Sensing Peptides PhrG, CSP and EDF Promote Angiogenesis and Invasion of Breast Cancer Cells In Vitro. PLoS ONE 10(3): e0119471. DOI: 10.1371/journal.pone.0119471.