• Update on PET radiopharmaceuticals for imaging hepatocellular carcinoma 

  Nyakale, Nozipho E.; Filippi, Luca; Aldous, Colleen; Sathekge, Mike Machaba (MDPI, 2023-04)

  Numerous positron emission tomography (PET) targets for detection and staging of hepatocellular cancer have been developed in recent years. Hepatocellular carcinomas (HCCs) are clinically and pathologically heterogeneous ...
• Correlation between [68Ga]Ga-FAPI-46 PET imaging and HIF-1 immunohistochemical analysis in cervical cancer: proof-of-concept 

  Mokoala, K.M.G. (Kgomotso); Lawal, Ismaheel Opeyemi; Maserumule, Letjie; Bida, Meshack; Maes, Alex; Ndlovu, Honest; Reed, Janet D.; Mahapane, Johncy; Davis, Cindy; Van de Wiele, Christophe; Popoola, Gbenga; Giesel, Frederik L.; Vorster, Mariza; Sathekge, Mike Machaba (MDPI, 2023-08-03)

  Hypoxia leads to changes in tumor microenvironment (upregulated CAFs) with resultant aggressiveness. A key factor in the physiological response to hypoxia is hypoxia-inducible factor-1alpha (HIF-1 ). [68Ga]Ga-FAPI PET ...
• Spotlight : the status of radiopharmacy in Africa 

  Kleynhans, Janke; Summers, Beverly; Sakr, Tamer; Zeevaart, Jan Rijn; Lundie, Maryke; Du Plessis, Samantha; Mosima, Lerato; Bentaleb, Naoual; Ekoume, Fany P.; Hlongwa, Khanyisile N.; Shambel, Seble; Mldophane, Amanda; Mangatha, Amreeta; More, Stuart (Springer, 2024-04)

  No abstract available.
• Feasibility and acceptability of web-based structured oral examinations for postgraduate certification : mixed methods preliminary evaluation 

  Burch, Vanessa; McGuire, Jessica; Buch, Eric; Sathekge, Mike Machaba; M'bouaffou, Francis; Senkubuge, Flavia; Fagan, Johannes (JMIR Publications, 2024-03)

  BACKGROUND : The COVID-19 pandemic disrupted postgraduate certification examinations globally. The Colleges of Medicine of South Africa continued hosting certification examinations through the pandemic. This was achieved ...
• Barriers and enablers for implementation of digital-linked diagnostics models at point-of-care in South Africa : stakeholder engagement 

  Moetlhoa, Boitumelo; Nxele, Siphesihle R.; Maluleke, Kuhlula; Mathebula, Evans Mantiri; Marange, Musa; Chilufya, Maureen; Dzinamarira, Tafadzwa; Duah, Evans; Dzobo, Matthias; Kekana, Mable; Jaya, Ziningi Nobuhle; Thabane, Lehana; Dlangalala, Thobeka; Nyasulu, Peter S.; Hlongwana, Khumbulani;; Dlungwane, Thembelihle; Kgatle, Mankgopo; Gxekea, Nobuhle; Mashamba‑Thompson, Tivani Phosa (BMC, 2024-02)

  The integration of digital technologies holds significant promise in enhancing accessibility to disease diagnosis and treatment at point-of-care (POC) settings. Effective implementation of such interventions necessitates ...
• Preclinical research highlighting contemporary targeting mechanisms of radiolabelled compounds for PET based infection imaging 

  Kleynhans, Janke; Sathekge, Mike Machaba; Ebenhan, Thomas (Elsevier, 2023-09)

  It is important to constantly monitor developments in the preclinical imaging arena of infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be identified to funnel into the clinic. Secondly, ...
• Insights into peptidoglycan-targeting radiotracers for imaging bacterial infections : updates, challenges, and future perspectives 

  Koatale, Palesa Caroline; Welling, Mick M.; Ndlovu, Honest; Kgatle, Mankgopo; Mdanda, Sipho; Mdlophane, Amanda; Okem, Ambrose; Takyi-Williams, John; Sathekge, Mike Machaba; Ebenhan, Thomas (American Chemical Society, 2024-02)

  The unique structural architecture of the peptidoglycan allows for the stratification of bacteria as either Gram-negative or Gram-positive, which makes bacterial cells distinguishable from mammalian cells. This classification ...
• A decade of ubiquicidin development for PET imaging of infection : a systematic review 

  Marjanovic-Painter, Biljana; Kleynhans, Janke; Zeevaart, Jan Rijn; Rohwer, Egmont Richard; Ebenhan, Thomas (Elsevier, 2023-01)

  BACKGROUND : Ubiquicidin is a peptide fragment with selective binding to negatively charged bacterial cell membranes. Besides its earlier labelling with gamma emitting radionuclides, it has been labelled with Positron ...
• Prostate cancer skeletal metastasis: a spontaneous evolution from osteolytic to osteoblastic morphology without treatment 

  Lawal, Ismaheel Opeyemi; Bilen, Mehmet A.; Halkar, Raghuveer K.; Jani, Ashesh B.; Schuster, David M. (Thieme Gruppe, 2023-12)

  Please read abstract in the article.
• Cancer treatment and survival among cervical cancer patients living with or without HIV in South Africa 

  Turdo, Yannick Q.; Ruffieux, Yann; Boshomane, T.M.G. (Tebatso); Mouton, Hannes; Taghavi, Katayoun; Haas, Andreas D.; Egger, Matthias; Maartens, Gary; Rohner, Eliane (Elsevier, 2022-10)

  OBJECTIVE : To compare cancer treatment and all-cause mortality between HIV-positive and HIV-negative cervical cancer patients in South Africa. METHODS : We assessed cancer treatment and all-cause mortality in HIV-positive ...
• A tale of 3 tracers : contrasting uptake patterns of 18F-fluciclovine, 68Ga-PSMA, and 18F-FDG in the uterus and adnexa 

  Lawal, Ismaheel Opeyemi; Adediran, Omotayo Atinuke; Muzahir, Saima; Friend, Sarah; Bhave, Manali Ajay; Meisel, Jane; Torres, Mylin A.; Styblo, Toncred Marya; Graham, Cathy; Holbrook, Anna; Kalinsky, Kevin; Fielder, Bridget; Crowe, Ronald J.; Ulaner, Gary A.; Schuster, David M. (Lippincott Williams and Wilkins, 2023-01)

  A 41-year-old woman with newly diagnosed invasive lobular carcinoma of the breast underwent sequential 68Ga-PSMA-11 PET/CT and 18F-fluciclovine PET/CT as part of an ongoing clinical trial (NCT04750473). 68Ga-PSMA PET/CT ...
• A discordant pattern of uptake on Ga-68-PSMA PET/CT versus F-18-fluciclovine PET/CT in radiation-induced hepatitis implications for early postradiotherapy imaging-based response assessment 

  Adediran, Omotayo A.; Lawal, Ismaheel Opeyemi; Muzahir, Saima; Bhave, Manali A.; Friend, Sarah; Fielder, Bridget; Meisel, Jane; Torres, Mylin A.; Styblo, Toncred M.; Graham, Cathy; Holbrook, Anna; Kalinsky, Kevin; Crowe, Ronald J.; Ulaner, Gary A.; Schuster, David M. (Lippincott Williams and Wilkins, 2023-04)

  A 62-year-old woman with right-sided invasive lobular breast carcinoma completed external beam radiotherapy 6 weeks before undergoing a 68Ga-PSMA PET/CT and 18F-fluciclovine PET/CT scan as part of an ongoing clinical trial ...
• Differences in failure-free survival after salvage radiotherapy guided by conventional imaging versus 18F-fluciclovine PET/CT in postprostatectomy patients : a post hoc substratification analysis of the EMPIRE-1 trial 

  Lawal, Ismaheel Opeyemi; Jani, Ashesh B.; Adediran, Omotayo A.; Goyal, Subir; Abiodun-Ojo, Olayinka A.; Dhere, Vishal R.; Marcus, Charles V.; Joshi, Shreyas S.; Master, Viraj A.; Patel, Pretesh R.; Goodman, Mark; Shelton, Joseph W.; Kucuk, Omer; Hershatter, Bruce; Fielder, Bridget; Halkar, Raghuveer K.; Schuster, David M. (Society of Nuclear Medicine and Molecular Imaging, 2023-04)

  Please read abstract in the article.
• Impact of 18F-fluciclovine PET/CT findings on failure-free survival in biochemical recurrence of prostate cancer following salvage radiation therapy 

  Lawal, Ismaheel Opeyemi; Marcus, Charles; Schuster, David M.; Goyal, Subir; Adediran, Omotayo A.; Dhere, Vishal R.; Joshi, Shreyas S.; Abiodun-Ojo, Olayinka A.; Master, Viraj A.; Patel, Pretesh R.; Fielder, Bridget; Goodman, Mark; Shelton, Joseph W.; Kucuk, Omer; Hershatter, Bruce; Halkar, Raghuveer K.; Jani, Ashesh B. (Lippincott Williams and Wilkins, 2023-04)

  Please read abstract in the article.
• Nuclear medicine training : skills and competencies required for practice in the 21st century 

  Lawal, Ismaheel Opeyemi (Thieme, 2023-06)

  Nuclear medicine (NM) utilizes unsealed radiation sources to diagnose and treat diseases. In the NM team, the NM physician works in collaboration with many other NM professionals who play critical roles in care delivery ...
• COP27 climate change conference: urgent action needed for Africa and the world : Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change 

  Atwoli, Lukoye; Erhabort, Gregory E.; Gbakima, Aiah A.; Haileamlak, Abraham; Kayembe Ntumba, Jean-Marie; Kigera, James; Langton, Laurie Laybourn; Mash, Bob; Joy, Muhia; Mulaudzi, Fhumulani Mavis; Ofori-Adjei, David; Okonofua, Friday; Arash, Rashidian; El-Adawy, Maha; Sidibé, Siaka; Snouber, Abdelmadjid; Tumwine, James; Yassien, Mohammad Sahar; Yonga, Paul; Zakhama, Lilia; Zielinski, Chris (Oxford University Press, 2023-01)
• Aberrant vascular anatomy associated with artifactual focal avidity in the liver on PSMA PET 

  Lawal, Ismaheel Opeyemi; Pectasides, Melina; Parihar, Ashwin Singh; Shah, Hardik U.; Halkar, Raghuveer K.; Jani, Ashesh B.; Schuster, David M. (Lippincott Williams and Wilkins, 2023-09)

  68Ga–prostate-specific membrane antigen (PSMA) PET/CT is a valuable tool for staging and restaging of prostate cancer. Prostate-specific membrane antigen expression is not specific to prostate cancer, as it is expressed ...
• Mental health, art adherence, and viral suppression among adolescents and adults living with HIV in South Africa : a cohort study 

  Haas, Andreas D.; Lienhard, Raphael; Didden, Christiane; Cornell, Morna; Folb, Naomi; Boshomane, Tebatso M.G.; Salazar‑Vizcaya, Luis; Rufeux, Yann; Nyakato, Patience; Wettstein, Anja E.; Tlali, Mpho; Davies, Mary‑Ann; Von Groote, Per; Wainberg, Milton; Egger, Matthias; Maartens, Gary; Joaska, John A. (Springer, 2023-06)

  We followed adolescents and adults living with HIV aged older than 15 years who enrolled in a South African private-sector HIV programme to examine adherence and viral non-suppression (viral load>400 copies/mL) of ...
• Imaging of invasive fungal infections- the role of PET/CT 

  Ankrah, Alfred O.; Lawal, Ismaheel Opeyemi; Dierckx, Rudi A.J.O.; Sathekge, Mike Machaba; Glaudemans, Andor W.J.M. (Elsevier, 2023-01)

  Over the last decades, the population at risk for invasive fungal disease (IFD) has increased because of medical therapy advances and diseases compromising patients' immune systems. The high morbidity and mortality associated ...
• Prognostic value of PSMA PET/CT in prostate cancer 

  Lawal, Ismaheel Opeyemi; Ndlovu, Honest; Kgatle, Mankgopo; Mokoala, K.M.G. (Kgomotso); Sathekge, Mike Machaba (Elsevier, 2024-01)

  Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the majority of prostate cancer (PCa). PSMA has an enzymatic function that makes metabolic substrates such as folate available for ...

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