Browsing Research Articles (Medical Microbiology) by Issue Date

Browsing Research Articles (Medical Microbiology) by Issue Date

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  • A phase 2 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 vaccine based on adeno-associated virus 
    Vardas, Eftyxia; Kaleebu, Pontiano; Bekker, Linda-Gail; Hoosen, Anwar Ahmed; Chomba, Elwyn; Johnson, Philip R.; Anklesaria, Pervin; Birungi, Josephine; Barin, Burc; Boaz, Mark; Cox, Josephine; Lehrman, Jennifer; Stevens, Gwynn; Gilmour, Jill; Tarragona, Tony; Hayes, Peter; Lowenbein, Sarah; Kizito, Eva; Fast, Patricia; Heald, Alison E.; Schmidt, Claudia (Mary Ann Liebert, 2010)
    The recombinant vaccine, tgAAC09, based on an adeno-associated virus serotype 2 (AAV2) vector encoding HIV-1 subtype C Gag, protease, and part of reverse transcriptase, induced robust T cell and antibody responses in ...
  • Clostridium difficile infections in a tertiary hospital : value of surveillance 
    Lekalakala, M. Ruth; Lewis, E.; Hoosen, Anwar Ahmed (Elsevier, 2010)
    No abstract available.
  • Pediatric disease burden and vaccination recommendations : understanding local differences 
    Gentile, Angela; Bhutta, Zulfiqar; Bravo, Lulu; Samy, Aly Gamal; Garcia, R. Dennis J.; Hoosen, Anwar Ahmed; Islam, Tazul; Karimi, Abdollah; Salem, Mona; Simasathien, Sriluck; Sohail, Amir; Watanaveeradej, Veerachai; Wiedenmayer, Karin; Schmitt, Heinz-J. (Elsevier, 2010)
    BACKGROUND: Diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HepB), invasive Haemophilus influenzae type b (Hib) disease, and measles cause substantial global morbidity and mortality. METHODS: This unique review ...
  • Mycoplasma genitalium : a brief review 
    Le Roux, Marie C.; Hoosen, Anwar Ahmed (Federation of Infectious Diseases Societies of South Africa, 2010-06)
    Mycoplasma genitalium belongs to the class Mollicutes and is the smallest prokaryote capable of independent replication. It was originally isolated from the urethras of two men with non-gonococcal urethritis (NGU). It has ...
  • Antimicrobial susceptibility patterns of selected bacteraemic isolates from South African public sector hospitals, 2010 
    Bamford, Colleen; Bonorchis, Kim; Ryan, Anthea; Simpson, John; Elliott, Eugenne; Hoffmann, Rena; Naicker, Preneshni; Ismail, Nazir Ahmed; Mbelle, Nontombi Marylucy; Nchabeleng, Maphoshane; Nana, Trusha; Sriruttan, Charlotte; Seetharam, Sharona; Wadula, Jeannette (Federation of Infectious Diseases Societies of South Africa, 2011)
    We report on antimicrobial susceptibility surveillance data for six key bloodstream pathogens (Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus ...
  • Human leukocyte antigens A*3001 and A*3002 show distinct peptide-binding Patterns of the Mycobacterium tuberculosis protein TB10.4 : consequences for immune recognition 
    Axelsson-Robertson, Rebecca; Ahmed, Raija K.; Weichold, Frank F.; Ehlers, Marthie Magdaleen; Kock, Marleen M.; Sizemore, Donata; Sadoff, Jerry; Maeurer, Markus (American Society for Microbiology, 2011-01)
    High-tuberculosis (TB)-burden countries are located in sub-Saharan Africa. We examined the frequency of human leukocyte antigen (HLA) alleles, followed by recombinant expression of the most frequent HLA-A alleles, i.e., ...
  • Infection prevention and control for viral infections 
    Lekalakala, M. Ruth (Health and Medical Publishing Group, 2011-05)
    Infection prevention and control (IPC) is the new terminology used for what was previously referred to as simply 'infection control'. It is an important component of health care and all health care workers (doctors, nurses, ...
  • Evaluation of TBc identification immunochromatographic assay for rapid identification of Mycobacterium tuberculosis complex in samples from broth cultures 
    Said, Halima Mohammed; Ismail, Nazir Ahmed; Osman, Ayman Gassim Elamin; Velsman, Chrisna; Hoosen, Anwar Ahmed (American Society for Microbiology, 2011-05)
    Tuberculosis (TB) is a disease of major public health concern worldwide, especially in developing countries. In addition, the human immunodeficiency virus (HIV) epidemic has increased the incidence of infection ...
  • More about... medical virology : Human papillomavirus (HPV) 
    Visser, Adele; Hoosen, Anwar Ahmed (Health and Medical Publishing Group, 2011-05)
    The WHO advocates introduction of routine HPV vaccination as part of a national EPI programme provided HPV prevention is considered a health priority, and the programme is logistically feasible and financially sustainable. ...
  • Multi-degree-of-freedom modeling of mechanical snubbing systems 
    Kaul, Sudhir (JVE International, 2011-06)
    This paper presents a multi-degree-of-freedom model for the design and analysis of mechanical snubbing in elastomeric isolators. The model consists of a three degree-of-freedom rigid body that is assembled to a rigid ...
  • Molecular basis of virulence in clinical isolates of Escherichia coli and Salmonella species from a tertiary hospital in the Eastern Cape, South Africa 
    Bisi-Johnson, Mary A.; Obi, Chikwelu Larry; Vasaikar, Sandeep D.; Baba, Kamaldeen A.; Hattori, Toshio (BioMed Central, 2011-06-10)
    BACKGROUND: Apart from localized gastrointestinal infections, Escherichia coli and Salmonella species are major causes of systemic disease in both humans and animals. Salmonella spp. cause invasive infections such as ...
  • Part IV. Human infections and antibiotic resistance 
    Crowther-Gibson, Penny; Govender, N.; Lewis, D.A.; Bamford, C.; Brink, A.; Von Gottberg, Anne; Klugman, Keith P.; Du Plessis, M.; Fali, A.; Harris, B.; Keddy, Karen H.; Botha, M. (Health and Medical Publishing Group, 2011-08)
    South Africa has a high burden of infectious diseases, including a large portion that are of bacterial origin. This section reviews the national burden of disease and levels of antibiotic resistance in common bacterial ...
  • Part VII : Interventions 
    Visser, Adele; Moore, D.P.; Whitelaw, Andrew; Lowman, W.; Kantor, G.; Hoosen, Anwar Ahmed; Madhi, Shabir A.; Brink, A.; Van den Bergh, D.; Devenish, L.; Moodley, P.; Apalata, T.; Duse, A.G.; Gelband, H. (Health and Medical Publishing Group, 2011-08)
    Antimicrobial resistance (AMR) surveillance activities in South Africa have been described in Part V of this report. Surveillance – knowing the levels of resistance and the trends around the country and in different ...
  • Part V. Surveillance activities 
    Bamford, C.; Brink, A.; Govender, N.; Lewis, D.A.; Perovic, Olga; Botha, M.; Harris, B.; Keddy, Karen H.; Gelband, H.; Duse, A.G. (Health and Medical Publishing Group, 2011-08)
    The critical importance of robust antimicrobial resistance (AMR) surveillance in South Africa cannot be overemphasised. Without knowing what the resistance situation is, it is impossible to develop appropriate antibiotic ...
  • Analytical performance of the Roche Lightcycler® Mycobacterium Detection Kit for the diagnosis of clinically important mycobacterial species 
    Omar, Shaheed Vally; Roth, Andreas; Ismail, Nazir Ahmed; Erasmus, Linda; Ehlers, Marthie Magdaleen; Kock, Marleen M.; Paulse, Nuraan; Said, H.M. (Halima Mohammed); Hoosen, Anwar Ahmed; Reischl, Udo (Public Library of Science, 2011-09-22)
    BACKGROUND: The LightCyclerH Mycobacterium Detection Kit based on real-time PCR technology for the detection of Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium kansasii was recently developed. This study ...
  • Meningococcal infections in hospitalised patients in Pretoria 
    Moodley, Teshni; Lekalakala, M. Ruth; De Gouveia, L.; Dangor, Yusuf; Hoosen, Anwar Ahmed (Health and Medical Publishing Group, 2011-10)
    We report on 13 patients diagnosed with meningococcal infections in patients attending state-owned hospitals serving an indigent population in Pretoria in 2009. The case fatality rate was 27%. Ceftriaxone was the main ...
  • Serotype and antimicrobial profile distribution of invasive pneumococcal isolates in the pre-vaccine introduction era in Pretoria, South Africa, 2005 through 2009 
    Ismail, Nazir Ahmed; Hoosen, Anwar Ahmed; Silberbauer, Eduard Johan; Von Gottberg, Anne (Elsevier, 2011-11)
    A description of invasive Streptococcus pneumoniae isolates over a 5-year period from blood culture and cerebrospinal fluid culture follows, in Pretoria South Africa January 2005 through December 2009. Isolates were ...
  • Biting off more than you can chew : microbiological flora isolated from human and animal bite wounds 
    Visser, Adele; Visser, Hilgaard Frans (Media 24 & South African Orthopaedic Association, 2012)
    BACKGROUND: Bite wounds, from human and animal origin, can lead to significant complications if appropriate therapy is not undertaken timeously. A basic knowledge of the microbiological flora is essential for each clinical ...
  • Prevalence of Clostridium difficile toxin genes in Pretoria 
    Storm, Nadia; Kock, Marleen M.; Kruger, M.D.; Ehlers, Marthie Magdaleen (Federation of Infectious Diseases Societies of South Africa, 2012)
    The hypervirulent polymerase chain reaction (PCR) ribotype 027 strain of Clostridium difficile produces toxins A, B and a binary toxin. Toxin detection kits are commonly used in diagnostic laboratories, but have been ...
  • Clinical trials of TB vaccines : harmonization and cooperation 
    Mahomed, Hassan; Fourie, P.B. (Petrus Bernardus) (Elsevier, 2012)
    A new efficacious tuberculosis (TB) vaccine has the potential to dramatically assist control efforts for the global TB epidemic. Good progress has been made with the clinical development of new TB vaccine candidates with ...