Meningococcal infections in hospitalised patients in Pretoria
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Date
Authors
Moodley, Teshni
Lekalakala, M. Ruth
De Gouveia, L.
Dangor, Yusuf
Hoosen, Anwar Ahmed
Journal Title
Journal ISSN
Volume Title
Publisher
Health and Medical Publishing Group
Abstract
We report on 13 patients diagnosed with meningococcal infections
in patients attending state-owned hospitals serving an indigent
population in Pretoria in 2009. The case fatality rate was 27%.
Ceftriaxone was the main antibiotic (9 out of 13 patients) for therapy.
Five isolates (39%) were serogroup B and 4 (31%) serogroup W135.
Most isolates (12/13) were fully susceptible to penicillin (MIC range
0.016 - 0.047 μg/ml). A single isolate was intermediately resistant
to penicillin (MIC, 0.125 μg/ml) while all isolates were uniformly
susceptible to ceftriaxone, ciprofloxacin and rifampicin. This
pattern reveals a shift in serogroups with an increase of serogroup B
disease in the Pretoria region, and the need for ongoing monitoring
of antimicrobial susceptibility profiles and the value of ceftriaxone
for favourable therapeutic outcome.
Description
Keywords
Meningococcal infections, Hospitalised patients, Pretoria
Sustainable Development Goals
Citation
Moodley, T, Lekalakala, MR, De Gouveia, L, Dangor, Y & Hoosen, AA 2011, 'Meningococcal infections in hospitalised patients in Pretoria', South African Medical Journal, vol. 101, no. 10, pp. 736-738.