Serotype and antimicrobial profile distribution of invasive pneumococcal isolates in the pre-vaccine introduction era in Pretoria, South Africa, 2005 through 2009
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Date
Authors
Ismail, Nazir Ahmed
Hoosen, Anwar Ahmed
Silberbauer, Eduard Johan
Von Gottberg, Anne
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
A description of invasive Streptococcus pneumoniae isolates over a 5-year period from blood culture and cerebrospinal fluid culture follows, in Pretoria South Africa January 2005 through December 2009. Isolates were identified using standard microbiological techniques, serotyped, and a MIC determined for penicillin and cefotaxime. A total of 177 isolates were included in the analysis. Eighty percent of patients in the 18- to 45-year age group tested positive for HIV. In children <5 years of age, 66% (n = 49) of serotypes were those present in the heptavalent pneumococcal conjugate vaccine (PCV-7). Fifty-nine percent (n = 29) were from PCV-7 serotypes in the <1-year-old age group. An additional peak of invasive disease was also seen in the 18- to 45-year age group. Only 1 of 177 isolates had resistance to penicillin (MIC ≥2 μg/mL); none was resistant to cefotaxime. The introduction of the PCV-7 vaccine in South Africa will decrease invasive pneumococcal disease caused by vaccine serotypes.
Description
Keywords
South Africa, Streptococcus pneumoniae, Pneumococcus, Vaccine, Pneumococcus conjugate vaccine
Sustainable Development Goals
Citation
Silberbauer, EJ, Ismail, N, Von Gottberg, A & Hoosen AA 2011, 'Serotype and antimicrobial profile distribution of invasive pneumococcal isolates in the pre-vaccine introduction era in Pretoria, South Africa, 2005 through 2009', Diagnostic Microbiology and Infectious Diseases, vol. 71, no. 3, pp.309-311.[http://www.sciencedirect.com/science/article/pii/S0732889311003014]