Serotype and antimicrobial profile distribution of invasive pneumococcal isolates in the pre-vaccine introduction era in Pretoria, South Africa, 2005 through 2009

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Authors

Ismail, Nazir Ahmed
Hoosen, Anwar Ahmed
Silberbauer, Eduard Johan
Von Gottberg, Anne

Journal Title

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Volume Title

Publisher

Elsevier

Abstract

A description of invasive Streptococcus pneumoniae isolates over a 5-year period from blood culture and cerebrospinal fluid culture follows, in Pretoria South Africa January 2005 through December 2009. Isolates were identified using standard microbiological techniques, serotyped, and a MIC determined for penicillin and cefotaxime. A total of 177 isolates were included in the analysis. Eighty percent of patients in the 18- to 45-year age group tested positive for HIV. In children <5 years of age, 66% (n = 49) of serotypes were those present in the heptavalent pneumococcal conjugate vaccine (PCV-7). Fifty-nine percent (n = 29) were from PCV-7 serotypes in the <1-year-old age group. An additional peak of invasive disease was also seen in the 18- to 45-year age group. Only 1 of 177 isolates had resistance to penicillin (MIC ≥2 μg/mL); none was resistant to cefotaxime. The introduction of the PCV-7 vaccine in South Africa will decrease invasive pneumococcal disease caused by vaccine serotypes.

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Keywords

South Africa, Streptococcus pneumoniae, Pneumococcus, Vaccine, Pneumococcus conjugate vaccine

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Citation

Silberbauer, EJ, Ismail, N, Von Gottberg, A & Hoosen AA 2011, 'Serotype and antimicrobial profile distribution of invasive pneumococcal isolates in the pre-vaccine introduction era in Pretoria, South Africa, 2005 through 2009', Diagnostic Microbiology and Infectious Diseases, vol. 71, no. 3, pp.309-311.[http://www.sciencedirect.com/science/article/pii/S0732889311003014]