Myataza, Asive; Thomas, Juno; Smith, Anthony M.(BMC, 2023-11)
BACKGROUND : We describe the genotypic characteristics and antimicrobial resistance (AMR) determinants of Salmonella
enterica serovar Isangi (Salmonella Isangi) clinical isolates in South Africa from 2020 through ...
BACKGROUND : The tuberculosis (TB) epidemic remains a major global health problem and Eswatini is not excluded.
Our study investigated the circulating genotypes in Eswatini and compared them at baseline (start of ...
Madhi, Shabir A.; Anderson, Annaliesa S.; Absalon, Judith; Radley, David; Simon, Raphael; Jongihlati, Babalwa; Strehlau, Renate; Van Niekerk, Anika M.; Izu, Alane; Naidoo, Niree; Kwatra, Gaurav; Ramsamy, Yogandree; Said, Mohamed; Jones, Stephanie; Jose, Lisa; Fairlie, Lee; Barnabas, Shaun L.; Newton, Ryan; Munson, Samantha; Jefferies, Zahra; Pavliakova, Danka; Silmon de Monerri, Natalie C.; Gomme, Emily; Perez, John L.; Scott, Daniel A.; Gruber, William C.; Jansen, Kathrin U.(Massachusetts Medical Society, 2023-07)
BACKGROUND : Natural history studies have correlated serotype-specific anti–capsular polysaccharide (CPS) IgG in newborns with a reduced risk of group B streptococcal disease. A hexavalent CPS–cross-reactive material 197 ...
Fry, Samantha; Chokephaibulkit, Kulkanya; Pallem, Sridevi; Henry, Ouzama; Pu, Yongjia; Akawung, Agnes; Kim, Joon Hyung; Yanni, Emad; Tullio, Antonella Nadia; Aurpibul, Linda; Lee, Christine Mui Fong; Ceballos, Ana; Zaman, Khalequ; Abadia de Regalado, Ivonne; Ahmed, Khatija; Arias Fernandez, Diana Andrea; Taher, Sri Wahyu; Caccavo, Juliana; Coutinho, Conrado Milani; D'Andrea Nores, Ulises; De Leon, Tirza; D'Silva, Emily Christine; De Bernardi, Mara; Dieser, Pablo; Falaschi, Andrea; Flores Acosta, Clara del Carmen; Gentile, Angela; Teo, Ik Hui; Kotze, Sheena; Lopez-Medina, Eduardo; Luca, Ruben; Lucion, Maria Florencia; Mantaring, Jacinto Blas V., III; Marin, Bladimir; Moelo, Malahleha; Mussi-Pinhata, Marisa Marcia; Pinto, Jorge; Puthanakit, Thanyawee; Reyes, Osvaldo; Roa, Maria Fernanda; Rodriguez Brieschke, Maria Teresa; Rodriguez, Camilo Enrique; Rodriguez Nino, Juan Nicolas; Schwarzbold, Alexandre Vargas; Sierra Garcia, Alexandra; Sivapatham, Lavitha; Soon, Ruey; Tinoco, Juan Carlos; Velasquez Penagos, Jesus Arnulfo; Dos Santos, Gael(Oxford University Press, 2023-12)
BACKGROUND : Incidence data of respiratory syncytial virus–associated lower respiratory tract illness (RSV-LRTI) are sparse in low- and middle-income countries (LMICs). We estimated RSV-LRTI incidence rates (IRs) in infants ...
Malahleha, M.; Dilraj, A.; Jean, J.; Morar, N.S.; Dietrich, J.J.; Ross, M.; Mbatsane, E.; Keefer, M.C.; Ahmed, Khatija(South African Medical Association, 2023-01)
BACKGROUND. The high HIV prevalence and incidence in South Africa makes it suitable for recruitment of participants for large-scale HIV
preventive vaccine trials. However, fear of vaccine-induced seropositivity (VISP) may ...
Peters, Remco P.H.; McIntyre, James A.; Garrett, N.; Brink, Adrian J.; Celum, Connie L.; Bekker, Linda‑Gail(AOSIS, 2023-09-28)
South Africa has a large burden of bacterial sexually transmitted infections (STIs) with high
rates among men who have sex with men (MSM). Randomised controlled trials have
recently demonstrated high effectiveness of ...
BACKGROUND : South Africa maintains an integrated health system where syndromic management of sexually transmitted infections (STI) is the standard of care. An estimated 2 million cases of Neisseria gonorrhoeae (N. ...
BACKGROUND : Reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread across Africa have varied, including among healthcare workers (HCWs). This study assessed the comparative SARS-CoV-2 burden and ...
Nocardiosis commonly affects the respiratory system and is a rare cause of purulent pericarditis. Invasive nocardial infections occur more frequently in patients with immunosuppression. A misdiagnosis as tuberculosis ...
Sebola, Dikeledi; Oguttu, James W.; Kock, Marleen M.; Qekwana, Daniel Nenene(Veterinary World, 2023-09-17)
BACKGROUND : Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic bacterial pathogens responsible for
hospital-acquired infections in veterinary medicine. Infection with these bacteria always requires urgent ...
CD4+ T cells have been found to play critical roles in the control of both acute and chronic
Toxoplasma infection. Previous studies identified a protective role for the Toxoplasma CD4+ T celleliciting
peptide AS15 ...
Ismail, Nazir Ahmed; Dippenaar, Anzaan; Warren, R.M.; Peters, Remco P.H.; Omar, Shaheed V.(American Society for Microbiology, 2023-04)
In Mycobacterium tuberculosis, bedaquiline and clofazimine resistance occurs primarily through Rv0678 variants, a gene encoding a repressor protein that regulates mmpS5/mmpL5 efflux pump gene expression. Despite the shared ...
Ngcelwane, M.V. (Mthunzi); Omar, Shaheed V.; Said, H.M. (Halima Mohammed); Bida, Nndweleni Meshack(Korean Society of Spine Surgery, 2023-06)
STUDY DESIGN : Prospective study.
PURPOSE : To evaluate the utility of whole genome sequencing (WGS) in drug resistance testing, lineage of the organisms, and organism-related factors responsible for bacilli settling in ...
BACKGROUND : Tuberculosis (TB) remains a significant global public health issue, despite
advances in diagnostic technologies, substantial global efforts, and the availability of effective
chemotherapies. Mycobacterium ...
Yebra, Gonzalo; Harling-Lee, Joshua D.; Lycett, Samantha; Aarestrup, Frank M.; Larsen, Gunhild; Cavaco, Lina M.; Seo, Keun Seok; Abraham, Sam; Schmidt, Tracy; Ehlers, M.M. (Marthie Magdaleen); Sordelli, Daniel O.; Buzzola, Fernanda R.; Gonçalves, Juliano L.; Dos Santos, Marcos V.; Zakaria, Zunita; Rall, Vera L.M.; Keane, Orla M.; Niedziela, Dagmara A.; Paterson, Gavin K.; Holmes, Mark A.; Freeman, Tom C.; Fitzgerald, J. Ross(National Academy of Sciences, 2022-12)
Most new pathogens of humans and animals arise via switching events from distinct
host species. However, our understanding of the evolutionary and ecological drivers of
successful host adaptation, expansion, and dissemination ...
Wake, Rachel M.; Govender, Nelesh; Omar, S.V. (Shaheed Vally); Ismail, Farzanah; Tiemessen, Caroline T.; Harrison, Thomas S.; Jarvis, Joseph N.(Lippincott, Williams & Wilkins, 2022-05)
OBJECTIVE : Investigation of the diagnostic yield of urine-based tuberculosis (TB) screening in patients with advanced HIV disease.
DESIGN : A cross-sectional screening study
SETTING : HIV outpatient clinics and wards ...
Antimicrobial resistance in Mycobacterium tuberculosis and Neisseria gonorrhoeae is emerging globally. Due to the limited treatment options, the World Health Organization has designated M. tuberculosis and N. gonorrhoeae ...
BACKGROUND : Bedaquiline improves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did a cross-sectional and longitudinal ...