• Clinical utility of the BioFire FilmArray Blood Culture Identification panel in the adjustment of empiric antimicrobial therapy in the critically ill septic patient 

  Rule, Roxanne; Paruk, Fathima; Becker, Piet J.; Neuhoff, Matthew; Chausse, Julian; Said, Mohamed (Public Library of Science, 2021-07)

  Sepsis and septic shock are key contributors to mortality in critically ill patients and thus prompt recognition and management thereof is central to achieving improved patient outcomes. Early initiation of appropriate ...
• Molecular epidemiology of extended-spectrum beta-lactamase–producing extra-intestinal pathogenic Escherichia coli strains over a 2-year period (2017–2019) from Zimbabwe 

  Takawira, Faustinos Tatenda; Pitout, Johann D.D.; Thilliez, Gaetan; Mashe, Tapfumanei; Gutierrez, Ana Victoria; Kingsley, Robert A.; Peirano, Gisele; Matheu, Jorge; Midzi, Stanley M.; Mwamakamba, Lusubilo W.; Gally, David L.; Tarupiwa, Andrew; Mukavhi, Leckson; Ehlers, Marthie Magdaleen; Mtapuri-Zinyowera, Sekesai; Kock, Marleen M. (Springer, 2022)

  This study was designed to characterize extended-spectrum beta-lactamase (ESBL)–producing extra-intestinal pathogenic Escherichia coli (E.coli) (ExPEC) associated with urinary tract infections in nine different geographic ...
• Molecular characterisation of β-lactamase producing Klebsiella pneumoniae isolates 

  De Jesus, Marissa Batista (University of Pretoria, 2015)

  Genetic typing of Klebsiella pneumoniae is used for epidemiological referencing. In the clinical setting it can be useful in outbreak investigations, understanding transmission and managing hospital infections. Multi-drug ...
• Risk factors for, and molecular epidemiology and clinical outcomes of, carbapenem- and polymyxin-resistant Gram-negative bacterial infections in pregnant women, infants, and toddlers : a systematic review and meta-analyses 

  Osei Sekyere, John; Reta, Melese Abate; Fourie, P.B. (Petrus Bernardus) (Wiley, 2021-10)

  Please read abstract in the article.
• Weight change among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception : findings from a randomised, multicentre, open-label trial 

  Beksinska, Mags; Issema, Rodal; Beesham, Ivana; Lalbahadur, Tharnija; Thomas, Katherine; Morrison, Charles; Hofmeyr, G. Justus; Steyn, Petrus S.; Mugo, Nelly; Palanee-Phillips, Thesla; Ahmed, Khatija; Nair, Gonasagrie; Baeten, Jared M.; Smit, Jenni (Elsevier, 2021-04)

  BACKGROUND : There is limited evidence on the impact of the use of progestin-only hormonal contraception (POC) on weight change. We conducted a secondary analysis of prospective weight change among women enrolled in the ...
• Comparison of targeted metagenomics and IS-Pro methods for analysing the lung microbiome 

  Goolam Mahomed, Tanweer; Peters, Remco P.H.; Pretorius, G.H.J.; Mahomed, A. Goolam; Ueckermann, Veronica; Kock, Marleen M.; Ehlers, Marthie Magdaleen (BioMed Central, 2021-08-18)

  BACKGROUND : Targeted metagenomics and IS-Pro method are two of the many methods that have been used to study the microbiome. The two methods target different regions of the 16 S rRNA gene. The aim of this study was to ...
• Composition of the vaginal microbiota during pregnancy in women living in sub- Saharan Africa : a PRISMA-compliant review 

  Juliana, Naomi C.A.; Peters, Remco P.H.; Al-Nasiry, Salwan; Budding, Andries E.; Morre, Servaas A.; Ambrosino, Elena (BioMed Central, 2021-09-03)

  BACKGROUND : The vaginal microbiota (VMB) are the set of microorganisms residing in the human vagina. During pregnancy, their composition is Lactobacillus-dominant in most Caucasian women. Previous studies suggest that the ...
• Emerging antimicrobial-resistant high-risk klebsiella pneumoniae clones ST307 and ST147 

  Peirano, Gisele; Chen, Liang; Kreiswirth, Barry N.; Pitout, Johann D.D. (American Society for Microbiology, 2020-09)

  There is an enormous global public health burden due to antimicrobial-resistant (AMR) Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent additions to the family of successful clones in the ...
• Persistent Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africa 

  Medina-Marino, Andrew; Mudau, Maanda; Kojima, Noah; Peters, Remco P.H.; Feucht, Ute Dagmar; De Vos, Lindsey; Olivier, Dawie; Muzny, Christina A.; McIntyre, James A.; Klausner, Jeffrey D. (Sage, 2020-03)

  The objective of this study is to assess the predictors and frequency of persistent sexually transmitted infection (STI) positivity in human immunodeficiency virus (HIV)-infected pregnant women treated for Chlamydia ...
• COVID-19 and its effects on the food production industry of South Africa 

  Karodia, A.; Hargovan, M.; Fadal, R.; Parker, W.; Singh, R.; Hoosen, Anwar Ahmed; Qekwana, Daniel Nenene; Mahomed, S. (South African Society of Occupational Medicine, 2020-07)

  No abstract available
• Sustaining essential healthcare in Africa during the COVID-19 pandemic 

  Ongole, J.J.; Rossouw, Theresa M.; Fourie, P.B. (Petrus Bernardus); Stoltz, Anton Carel; Hugo, Johannes F.M.; Marcus, Tessa S. (International Union Against Tuberculosis and Lung Disease, 2020-06)

  No abstract available.
• Systematic rifampicin resistance errors with Xpert® MTB/RIF Ultra : implications for regulation of genotypic assays 

  Omar, S.V.; Hillemann, D.; Pandey, S.; Merker, M.; Witt, A.K.; Nadarajan, D.; Barilar, I.; Bainomugisa, A.; Kelly, E.C.; Diel, R.; Vidanagama, D.S.; Samarasinghe, A.I.P.; Cader, M.R.; Goetsch, U.; Lavu, E.; Alabi, A.; Schon, T.; Coulter, C.; Niemann, S.; Maurer, F.P.; Ismail, Nazir Ahmed; Koser, C.U.; Ismail, F. (International Union Against Tuberculosis and Lung Disease, 2020-12)

  No abstract available.
• Maximising the efficiency of surveillance for COVID-19 in dialysis units in South Africa : the case for pooled testing 

  Fadal, Riyas; Wadee, Shoyab; Hoosen, Anwar Ahmed (Health and Medical Publishing Group, 2020-08)

  The COVID-19 epidemic in South Africa (SA) is currently in a growth phase with high incidences in most major cities. Patients who are dependent on chronic renal dialysis care, including peritoneal dialysis and haemodialysis, ...
• Distribution and clonality of drug-resistant tuberculosis in South Africa 

  Said, Halima; Ratabane, John; Erasmus, Linda; Gardee, Yasmin; Omar, Shaheed; Dreyer, Andries; Ismail, Farzana; Bhyat., Zaheda; Lebaka, Tiisetso; Van der Meulen, Minty; Gwala, Thabisile; Adelekan, Adeboye; Diallo, Karidia; Ismail, Nazir Ahmed (BMC, 2021-05)

  BACKGROUND: Studies have shown that drug-resistant tuberculosis (DR-TB) in South Africa (SA) is clonal and is caused mostly by transmission. Identifying transmission chains is important in controlling DR-TB. This study ...
• WASH infrastructure and practices in primary health care clinics in the rural Vhembe district municipality in South Africa 

  Potgieter, N.; Banda, N.T.; Becker, Piet J.; Traore-Hoffman, A.N. (BMC, 2021-01)

  BACKGROUND: South Africa has unique and diverse social and economic factors that have an impact on the provision of basic water, sanitation, hygiene and waste management infrastructure and practices at health care facilities ...
• In vitro antibacterial activity of Loxostylis alata extracts and isolated compounds against Salmonella species 

  Gado, Dorcas A.; Abdalla, Muna Ali; Ahmed, Aroke Shahid; Madikizela, Balungile; Nkadimeng, Sanah Malomile; Ehlers, Marthie Magdaleen; McGaw, Lyndy Joy (BMC, 2021-04)

  BACKGROUND: Owing to antibiotic resistance, alternative antimicrobials from medicinal plants are receiving attention as leads for anti-infective agents. This study aimed to investigate selected tree species and their ...
• ART initiation among women newly diagnosed with HIV in a contraceptive trial in sub-Saharan Africa 

  Beesham, Ivana; Issema, Rodal; Palanee-Phillips, Thesla; Onono, Maricianah; Evans, Shannon; Beksinska, Mags; Ahmed, Khatija; Kasaro, Margaret P.; Batting, Joanne; Deese, Jennifer; Dlaminii, Lunga; Yankurije, Berthe; Thomas, Katherine K.; Heffron, Renee (Taylor and Francis, 2021)

  Current guidelines recommend starting antiretroviral therapy (ART) as soon as possible after HIV diagnosis to reduce morbidity, mortality and onward HIV transmission. We examined factors influencing ART initiation by ...
• Modeling missing cases and transmission links in networks of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa 

  Nelson, Kristin N.; Gandhi, Neel R.; Mathema, Barun; Lopman, Benjamin A.; Brust, James C.M.; Auld, Sara C.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Brown, Tyler S.; Allana, Salim; Campbell, Angie; Moodley, Pravi; Mlisana, Koleka; Shah, N. Sarita; Jenness, Samuel M. (Oxford University Press, 2020-07)

  Patterns of transmission of drug-resistant tuberculosis (TB) remain poorly understood, despite over half a million incident cases worldwide in 2017. Modeling TB transmission networks can provide insight into drivers of ...
• Genomic analysis of a multidrug-resistant clinical Providencia rettgeri (PR002) strain with the novel integron ln1483 and an A/C plasmid replicon 

  Mbelle, Nontombi Marylucy; Osei Sekyere, John; Amoako, Daniel Gyamfi; Maningi, Nontuthuko Excellent; Modipane, Lesedi; Essack, Sabiha Yusuf; Feldman, Charles (Wiley, 2020-02)

  Please read abstract in the article.
• Validation of bedaquiline phenotypic drug susceptibility testing methods and breakpoints : a multilaboratory, multicountry study 

  Kaniga, Koné; Aono, Akio; Borroni, Emanuele; Cirillo, Daniela Maria; Desmaretz, Christel; Hasan, Rumina; Joseph, Lavania; Mitarai, Satoshi; Shakoor, Sadia; Torrea, Gabriela; Ismail, Nazir Ahmed; Omar, Shaheed V (American Society for Microbiology, 2020-04)

  Drug-resistant tuberculosis persists as a major public health concern. Alongside efficacious treatments, validated and standardized drug susceptibility testing (DST) is required to improve patient care. This multicountry, ...

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