COVID-19 Is a multi-organ aggressor : epigenetic and clinical marks

Kgatle, Mankgopo; Lawal, Ismaheel Opeyemi; Mashabela, Gabriel; Boshomane, Tebatso M.G.; Koatale, Palesa Caroline; Mahasha, Phetole Walter; Ndlovu, Honest; Vorster, Mariza; Rodrigues, Hosana Gomes; Zeevaart, Jan Rijn; Gordon, Siamon; Moura-Alves, Pedro; Sathekge, Mike Machaba

dc.contributor.author	Kgatle, Mankgopo
dc.contributor.author	Lawal, Ismaheel Opeyemi
dc.contributor.author	Mashabela, Gabriel
dc.contributor.author	Boshomane, Tebatso M.G.
dc.contributor.author	Koatale, Palesa Caroline
dc.contributor.author	Mahasha, Phetole Walter
dc.contributor.author	Ndlovu, Honest
dc.contributor.author	Vorster, Mariza
dc.contributor.author	Rodrigues, Hosana Gomes
dc.contributor.author	Zeevaart, Jan Rijn
dc.contributor.author	Gordon, Siamon
dc.contributor.author	Moura-Alves, Pedro
dc.contributor.author	Sathekge, Mike Machaba
dc.date.accessioned	2022-03-10T10:59:42Z
dc.date.available	2022-03-10T10:59:42Z
dc.date.issued	2021-10-08
dc.description.abstract	The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID- 19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.	en_ZA
dc.description.department	Nuclear Medicine	en_ZA
dc.description.librarian	am2022	en_ZA
dc.description.uri	http://www.frontiersin.org/Immunology	en_ZA
dc.identifier.citation	Kgatle, M.M., Lawal, I.O., Mashabela, G., Boshomane, T.M.G., Koatale, P.C., Mahasha, P.W., Ndlovu, H., Vorster, M., Rodrigues, H.G., Zeevaart, J.R., Gordon, S., Moura-Alves, P. & Sathekge, M.M. (2021) COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks. Frontiers in Immunology 12:752380. DOI: 10.3389/fimmu.2021.752380	en_ZA
dc.identifier.issn	1664-3224 (online)
dc.identifier.other	10.3389/fimmu.2021.752380
dc.identifier.uri	http://hdl.handle.net/2263/84424
dc.language.iso	en	en_ZA
dc.publisher	Frontiers Research Foundation	en_ZA
dc.rights	© 2021 Kgatle, Lawal,Mashabela, Boshomane, Koatale,Mahasha, Ndlovu, Vorster, Rodrigues, Zeevaart, Gordon, Moura-Alves and Sathekge. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).	en_ZA
dc.subject	Cytokine storm	en_ZA
dc.subject	Epigenetics	en_ZA
dc.subject	Multi-organ	en_ZA
dc.subject	Pro-inflammatory cytokines	en_ZA
dc.subject	Coronavirus disease 2019 (COVID-19)	en_ZA
dc.subject	COVID-19 pandemic	en_ZA
dc.subject	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)	en_ZA
dc.subject	Angiotensin-converting enzyme 2 (ACE2)	en_ZA
dc.subject	Transmembrane serine protease 2 (TMPRSS2)	en_ZA
dc.title	COVID-19 Is a multi-organ aggressor : epigenetic and clinical marks	en_ZA
dc.type	Article	en_ZA