dc.contributor.author |
Dutta, Jyotibon
|
|
dc.contributor.author |
Baijnath, Sooraj
|
|
dc.contributor.author |
Somboro, Anou M.
|
|
dc.contributor.author |
Nagiah, Savania
|
|
dc.contributor.author |
Albericio, Fernando
|
|
dc.contributor.author |
De la Torre, Beatriz G.
|
|
dc.contributor.author |
Marjanovic-Painter, Biljana
|
|
dc.contributor.author |
Zeevaart, Jan Rijn
|
|
dc.contributor.author |
Sathekge, Mike Machaba
|
|
dc.contributor.author |
Kruger, Hendrik G.
|
|
dc.contributor.author |
Chuturgoon, Anil
|
|
dc.contributor.author |
Naicker, Tricia
|
|
dc.contributor.author |
Ebenhan, Thomas
|
|
dc.contributor.author |
Govender, Thavendran
|
|
dc.date.accessioned |
2018-01-15T08:13:11Z |
|
dc.date.issued |
2017-10 |
|
dc.description.abstract |
Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the infectious foci; however, the radiotracers available are either cumbersome to prepare or their exact contribution toward the imaging is not yet established. Human antimicrobial peptides are of interest for development as PET radiotracers as they are an integral component of the immune system, non-immunogenic toward the recipient, and show selectivity toward pathogens such as bacteria. Herein we report on the potential of LL37, a human cathelicidin antimicrobial peptide, as a radiotracer for bacterial imaging. Bifunctional chelator 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid was utilized to functionalize the antimicrobial peptide, which in turn was capable of chelating gallium. The synthesized natGa-CDP1 showed bacterial selectivity and low affinity toward hepatic cells, which are favorable characteristics for further preclinical application. |
en_ZA |
dc.description.department |
Nuclear Medicine |
en_ZA |
dc.description.embargo |
2018-10-30 |
|
dc.description.librarian |
hj2018 |
en_ZA |
dc.description.sponsorship |
The Department of Science and Technology, University of KwaZulu Natal, National Research Foundation and Aspen Pharmacare. |
en_ZA |
dc.description.uri |
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1747-0285 |
en_ZA |
dc.description.uri |
http://wileyonlinelibrary.com/journal/cbdd |
en_ZA |
dc.identifier.citation |
Dutta, J., Baijnath, S., Somboro, A.M. et al. 2017, 'Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection', Chemical Biology and Drug Design, vol. 90, no. 4, pp. 572-579. |
en_ZA |
dc.identifier.issn |
1747-0277 (print) |
|
dc.identifier.issn |
1747-0285 (online) |
|
dc.identifier.other |
10.1111/cbdd.12980 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/63536 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Wiley |
en_ZA |
dc.rights |
© 2017 John Wiley & Sons A/S. This is the pre-peer reviewed version of the following article : 'Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection', Chemical Biology and Drug Design, vol. 90, no. 4, pp. 572-579, 2017, doi : 10.1111/cbdd.12980 . The definite version is available at : http://onlinelibrary.wiley.comjournal/10.1111/(ISSN)1747-0285. |
en_ZA |
dc.subject |
Solid-phase peptide synthesis |
en_ZA |
dc.subject |
Bacteria |
en_ZA |
dc.subject |
CDP1 |
en_ZA |
dc.subject |
Infection |
en_ZA |
dc.subject |
LL37 |
en_ZA |
dc.subject |
NODAGA |
en_ZA |
dc.subject |
Positron emission tomography (PET) |
en_ZA |
dc.subject |
Antimicrobial peptide (AMP) |
en_ZA |
dc.subject |
Cathelicidin |
en_ZA |
dc.subject |
Inflamation |
en_ZA |
dc.subject |
Diagnosis |
en_ZA |
dc.subject |
Medicine |
en_ZA |
dc.subject |
Radiotracers |
en_ZA |
dc.subject |
Protein |
en_ZA |
dc.title |
Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection |
en_ZA |
dc.type |
Postprint Article |
en_ZA |