dc.contributor.author |
De Spiegeleer, Bart
|
|
dc.contributor.author |
Verbeke, Frederick
|
|
dc.contributor.author |
D’Hondt, Matthias
|
|
dc.contributor.author |
Hendrix, An
|
|
dc.contributor.author |
Van de Wiele, Christophe
|
|
dc.contributor.author |
Burvenich, Christian
|
|
dc.contributor.author |
Peremans, Kathelijne
|
|
dc.contributor.author |
De Wever, Olivier
|
|
dc.contributor.author |
Bracke, Marc
|
|
dc.contributor.author |
Wynendaele, Evelien
|
|
dc.date.accessioned |
2016-09-19T09:18:02Z |
|
dc.date.available |
2016-09-19T09:18:02Z |
|
dc.date.issued |
2015-03-17 |
|
dc.description |
S1 Table. List of quorum sensing peptides, repeatedly (n = 3) investigated for their effect
on tumour cell invasion (Collagen Type 1 invasion assay). |
en_ZA |
dc.description.abstract |
The role of the human microbiome on cancer progression remains unclear. Therefore, in
this study, we investigated the influence of some quorum sensing peptides, produced by diverse
commensal or pathogenic bacteria, on breast cancer cell invasion and thus cancer
outcome. Based on microscopy, transcriptome and Chick Chorioallantoic Membrane
(CAM) analyses, four peptides (PhrG from B. subtilis, CSP from S. mitis and EDF from
E. coli, together with its tripeptide analogue) were found to promote tumour cell invasion
and angiogenesis, thereby potentially influencing tumour metastasis. Our results offer not
only new insights on the possible role of the microbiome, but also further opportunities in
cancer prevention and therapy by competing with these endogenous molecules and/or by
modifying people’s life style. |
en_ZA |
dc.description.department |
Nuclear Medicine |
en_ZA |
dc.description.librarian |
am2016 |
en_ZA |
dc.description.sponsorship |
The Special
Research Fund of Ghent University [Grant number
BOF 01J22510 to BDS and EW, and the Institute
for the Promotion of Innovation through Science and
Technology in Flanders (IWT-Vlaanderen) [Grant
numbers 131356 to FV and 101529 to MD. |
en_ZA |
dc.description.uri |
http://www.plosone.org |
en_ZA |
dc.identifier.citation |
De Spiegeleer B, Verbeke F, D’Hondt M,
Hendrix A, Van De Wiele C, Burvenich C, et al.
(2015) The Quorum Sensing Peptides PhrG, CSP
and EDF Promote Angiogenesis and Invasion of
Breast Cancer Cells In Vitro. PLoS ONE 10(3):
e0119471. DOI: 10.1371/journal.pone.0119471. |
en_ZA |
dc.identifier.issn |
1932-6203 |
|
dc.identifier.other |
10.1371/journal.pone.0119471 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/56747 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Public Library of Science |
en_ZA |
dc.rights |
© 2015 De Spiegeleer et al. This is an
open access article distributed under the terms of the
Creative Commons Attribution License. |
en_ZA |
dc.subject |
Human microbiome |
en_ZA |
dc.subject |
Therapy |
en_ZA |
dc.subject |
Prevention |
en_ZA |
dc.subject |
Breast cancer |
en_ZA |
dc.title |
The quorum sensing peptides PhrG, CSP and EDP promote angiogenesis and invasion of breast cancer cells in vitro |
en_ZA |
dc.type |
Article |
en_ZA |