Browsing Research Articles (Pharmacology) by Title

Browsing Research Articles (Pharmacology) by Title

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  • Saving student interaction by saving the Starks 
    Parkar, Hafiza (Health and Medical Publishing Group, 2021-10)
    The pharmacology of antibacterials can be a tricky topic to lecture to students at any level. The cohort that we have is comprised of first-year medical students in their second semester, and teaching antibacterials at ...
  • Sick and tired of COVID-19 : long haulers and post viral (fatigue) syndromes 
    Outhoff, Kim (Medpharm Publications, 2020)
    COVID-19 patients may face a long and winding road to recovery. Outcomes of critically ill patients have been well described, including in China, Italy and the USA, and particularly in the comorbid elderly. However, short-, ...
  • A simplified workflow with end-point validation of real-time electrical cell-substrate impedance sensing of retinoic acid stimulated neurogenesis in human SH-SY5Y cells in vitro 
    Joos‑Vandewalle, Julia; Steenkamp, Vanessa; Prinsloo, Earl (BMC, 2023-06-01)
    OBJECTIVE : Retinoic acid (RA) is known to transition proliferating SH-SY5Y neuroblastoma cells towards functional neurons. However, the activity of RA is restricted due to its photolability where any findings from prolonged ...
  • Social media and COVID-19-perceptions and public deceptions of ivermectin, colchicine and hydroxychloroquine : lessons for future pandemics 
    Schellack, Natalie; Strydom, Morne A.; Pepper, Michael Sean; Herd, Candice Lee; Hendricks, Candice Laverne; Bronkhorst, Elmien; Meyer, Johanna C.; Padayachee, Neelaveni; Bangalee, Varsha; Truter, Ilse; Ellero, Andrea Antonio; Myaka, Thulisa; Naidoo, Elysha; Godman, Brian (MDPI, 2022-04)
    The capacity for social media to influence the utilization of re-purposed medicines to manage COVID-19, despite limited availability of safety and efficacy data, is a cause for concern within health care systems. This ...
  • Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition 
    Burger, Trevor; Mokoka, Tsholofelo; Fouche, Gerda; Steenkamp, Paul; Steenkamp, Vanessa; Cordier, Werner (BioMed Central, 2018-05-02)
    BACKGROUND : Solanum aculeastrum fruits are used by some cancer sufferers as a form of alternative treatment. Scientific literature is scarce concerning its anticancer activity, and thus the aim of the study was to assess ...
  • The sore throat : a clinical approach to tonsillopharyngitis 
    Marais, Andre; Leuschner, Machel (Medpharm Publications, NISC (Pty) and Cogent, Taylor and Francis Group, 2019-06)
    Acute sore throat is a common complaint encountered by medical practitioners and health care workers routinely. The disease is mostly caused by viral infections of the upper respiratory tract and is usually self-limiting. ...
  • South African physiotherapists’ attitudes to medicine prescription as an extension of practice 
    Kakono, Tsungirirai V.; Mathye, Desmond; Brand, S.J. (Sarel); Cordier, Werner (AOSIS Open Journals, 2023-06-23)
    BACKGROUND : The extension of medicine prescription rights to other healthcare providers was proposed to reduce pharmacotherapeutic service delivery challenges in the South African healthcare sector. The scope of practice ...
  • Sperm-friendly lubricant : fact or fiction 
    Markram, Johan; Griessel, Lizelle; Girdler-Brown, B.V. (Brendan); Outhoff, Kim (Wiley, 2022-10)
    OBJECTIVE : To assess the effects of “sperm-friendly” coital lubricants on sperm motility. METHODS : This study compared the effects of five lubricants (Optilube®, Pre-Seed®, Yes Baby®, olive oil, and egg white) on sperm ...
  • Stability, morphology, and effects of in vitro digestion on the antioxidant properties of polyphenol inclusion complexes with -cyclodextrin 
    Ntuli, Sunday; Leuschner, Machel; Bester, Megan; Serem, June Cheptoo (MDPI, 2022-06-14)
    Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility. Encapsulation has been shown to overcome some of these limitations. A ...
  • Stimulating students' critical thinking skills in pharmacology using case report generation 
    Mlambo, Shamiso Shelter (Health & Medical Publishing Group, 2021-09)
    It is not a debatable issue that the COVID‑19 pandemic created several challenges in the education sector, and institutions across the world had to employ various interventions to ensure continuation of teaching and learning. ...
  • Stress-related IBS 
    Outhoff, Kim (MedPharm Publications, 2016)
    The gastrointestinal tract is exquisitely sensitive to different physical and psychological stressors. Irritable bowel syndrome (IBS) may be viewed as a disorder caused by stress-induced dysregulation of the complex ...
  • A summary overview of the new, direct, target-specific oral anticoagulants 
    Muntingh, George L. (MedPharm Publications, 2016)
    In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC) or better referred to as direct oral anticoagulants (DOAC) or target-specific oral ...
  • Switching antidepressants 
    Outhoff, Kim (MedPharm Publications, 2015)
    Switching antidepressants because of lack of efficacy or unacceptable side-effects, while often required in general practice, may result in toxic drug-drug interactions, worsening depression or unpleasant discontinuation ...
  • Synthesis and biological evaluation of (E)-cinnamic acid, (E)-2-styrylthiazole and (E)-2-[2-(naphthalen-1-yl)vinyl]thiazole derivatives 
    Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. (Michigan Publishing, 2017-04)
    Cinnamyl- and thiazole-based compounds have been shown to exhibit diverse medicinal properties and a series of twelve (E)-2-styrylthiazole and (E)-2-[(naphthalen-1-yl)vinyl]thiazole derivatives, which are conjugates of ...
  • Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones 
    Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. (Elsevier, 2019-07)
    A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones have been prepared and shown to exhibit promising concentration-dependent activity against human SH-SY5Y cells, Plasmodium falciparum, ...
  • Synthesis and biological screening of diethyl [N-(thiazol-2-yl)carbamoyl]methylphosphonates 
    Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich C.; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. (ARKAT, 2018-09-09)
    A three-step synthesis, involving condensation of bromomethyl aryl ketones with urea to afford 2- aminothiazoles, their chloroacetylation and subsequent solvent-free Arbuzov phosphonation has afforded a series of novel ...
  • Synthesis, antibacterial, and cytotoxicity evaluation of oleanolic acid-4-aminoquinoline based hybrid compounds 
    Khwaza, Vuyolwethu; Oyedeji, Opeoluwa O.; Aderibigbe, Blessing A.; Morifi, Eric; Fonkui, Thierry Y.; Ndinteh, Derek T.; Steenkamp, Vanessa (Bentham Science, 2021-02)
    AIM : The study aims to prepare a class of oleanolic-based compounds. BACKGROUND : Conventional drugs used to treat infectious diseases suffer from limitations such as drug toxicity and drug resistance. The resistance ...
  • Tackling antimicrobial resistance across sub-Saharan Africa : current challenges and implications for the future 
    Godman, Brian; Egwuenu, Abiodun; Wesangula, Evelyn; Schellack, Natalie; Kalungia, Aubrey Chichonyi; Tiroyakgosi, Celda; Kgatlwane, Joyce; Mwita, Julius; Patrick, Okwen; Niba, Loveline Lum; Amu, Adefolarin A.; Oguntade, Racheal Tomilola; Alabi, Mobolaji Eniola; Ncube, Nondumiso B.Q.; Sefah, Israel Abebrese; Acolatse, Joseph; Incoom, Robert; Guantai, Anastasia Nkatha; Oluka, Margaret; Opanga, Sylvia; Chikowe, Ibrahim; Khuluza, Felix; Chiumia, Francis K.; Jana, Collins Edward; Kalemeera, Francis; Hango, Ester; Fadare, Joseph; Ogunleye, Olayinka O.; Ebruke, Bernard E.; Meyer, Johanna C.; Massele, Amos; Malande, Oliver Ombeva; Kibuule, Dan; Kapona, Otridah; Zaranyika, Trust; Bwakura-Dangarembizi, Mutsa; Kujinga, Tapiwanashe; Saleem, Zikria; Kurdi, Amanj; Shahwan, Moyad; Jairoun, Ammar Abdulrahman; Wale, Janney; Brink, Adrian (Taylor and Francis, 2022)
    INTRODUCTION : Antimicrobial resistance (AMR) is a concern as this increases morbidity, mortality, and costs, with sub-Saharan Africa having the highest rates globally. Concerns with rising AMR have resulted in international, ...
  • Targeting specific checkpoints in the management of SARS-CoV-2 induced cytokine storm 
    Abubakar, Abdullahi Rabiu; Ahmad, Rahnuma; Rowaiye, Adekunle Babajide; Rahman, Sayeeda; Iskandar, Katia; Dutta, Siddhartha; Oli, Angus Nnamdi; Dhingra, Sameer; Tor, Maryam Abba; Etando, Ayukafangha; Kumar, Santosh; Irfan, Mohammed; Gowere, Marshall; Chowdhury, Kona; Jahan, Dilshad; Schellack, Natalie; Haque, Mainul (MDPI, 2022-03-25)
    COVID-19-infected patients require an intact immune system to suppress viral replication and prevent complications. However, the complications of SARS-CoV-2 infection that led to death were linked to the overproduction ...
  • Teaching pharmacology online : not just another narration 
    Cordier, Werner; Lubbe, J.C. (Irene) (Health and Medical Publishing Group, 2021-09)
    The COVID-19 pandemic placed educators in unique circumstances, not only due to their discipline- and student-specific considerations, but also their personal and professional milieu. Given a series of sudden ...