In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC)
or better referred to as direct oral anticoagulants (DOAC) or target-specific oral anticoagulants (TSOAC). These drugs have some
definite advantages and disadvantages that should be clear to physicians before prescribing any of them for patients. Many clinical
trials have provided definitive information about the efficacy and safety of DOACs, yet many physicians remain sceptical about
prescribing these drugs due to lack of answers to real world questions. The concerns are directed towards appropriate patient
selection (the choice should be made according to age, renal function, compliance, cost, clinical condition, intake of other drugs),
the mechanism of switching between agents, how these drugs affect routine laboratory tests and when monitoring is needed.
Knowledge of other drugs that interact with the DOAC and management of severe bleeding will be reviewed and recommendations
will be given to all of these concerns.
Osuch, Elzbieta; Marais, Andre(AOSIS Open Journals, 2019)
Haemostasis and thrombosis rely on three components namely the vascular endothelial wall, blood platelets and the coagulation cascade. Non-physiologic excessive thrombosis occurs when haemostatic processes are dysfunctional, ...
The quality and validity of laboratory results, especially for coagulation analyses, are influenced by pre-analytical variables including the collection technique, transportation, pre-analytical processing and storage of ...