In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC)
or better referred to as direct oral anticoagulants (DOAC) or target-specific oral anticoagulants (TSOAC). These drugs have some
definite advantages and disadvantages that should be clear to physicians before prescribing any of them for patients. Many clinical
trials have provided definitive information about the efficacy and safety of DOACs, yet many physicians remain sceptical about
prescribing these drugs due to lack of answers to real world questions. The concerns are directed towards appropriate patient
selection (the choice should be made according to age, renal function, compliance, cost, clinical condition, intake of other drugs),
the mechanism of switching between agents, how these drugs affect routine laboratory tests and when monitoring is needed.
Knowledge of other drugs that interact with the DOAC and management of severe bleeding will be reviewed and recommendations
will be given to all of these concerns.
OBJECTIVE : To document maternal and foetal morbidity and
mortality in anticoagulated, pregnant patients with mechanical
heart valves until 42 days postpartum.
METHODS : In a tertiary single-centre, prospective cohort,
Botha, C.J. (Christoffel Jacobus); Venter, Elna; University of Pretoria. Faculty of Veterinary Science. Dept. of Paraclinical Sciences. Section Pharmacology and Toxicology(2002)
Widespread. Grows in moist conditions in disturbed areas.
Botanical description: General: An annual shrublet that can grow up to 1 m high. Leaves: The leaflets are shallowly toothed in the upper two thirds. ...