In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC)
or better referred to as direct oral anticoagulants (DOAC) or target-specific oral anticoagulants (TSOAC). These drugs have some
definite advantages and disadvantages that should be clear to physicians before prescribing any of them for patients. Many clinical
trials have provided definitive information about the efficacy and safety of DOACs, yet many physicians remain sceptical about
prescribing these drugs due to lack of answers to real world questions. The concerns are directed towards appropriate patient
selection (the choice should be made according to age, renal function, compliance, cost, clinical condition, intake of other drugs),
the mechanism of switching between agents, how these drugs affect routine laboratory tests and when monitoring is needed.
Knowledge of other drugs that interact with the DOAC and management of severe bleeding will be reviewed and recommendations
will be given to all of these concerns.
De Beer, Chantel J.; Venter, Gert J.; Vreysen, Marc J.(Public Library of Science, 2016-12-22)
One of the challenges to maintain tsetse fly (Diptera: Glossinidae) colonies is the sustainable
supply of high quality blood meals. The effect of using anticoagulants during collection
of the blood, the addition of ...
Jacobson, B.F.; Louw, S.; Buller, H.; Mer, M.; De Jong, P.R.; Rowji, P.; Schapkaitz, E.; Adler, D.; Beeton, A.; Hsu, H-C.; Wessels, P.F.; Haas, S.(Health and Medical Publishing Group, 2013-04)
BACKGROUND: Pharmacological prophylactic anticoagulation in many countries, including South Africa, is under-prescribed. This has
resulted in unacceptable rates of morbidity and mortality.
METHOD: The Southern African ...