Eksteen, M.; Maimin, J.; De Beer, N.; Padayachee, N.; Schellack, Natalie(Medpharm Publications, 2023)
Pharmacy council inspectors play a crucial role in ensuring the quality, safety, and compliance of pharmacies with established regulations and standards. These inspectors are typically appointed by pharmacy regulatory ...
Ker, James A.; Outhoff, Kim(Medpharm Publications, 2023)
This article outlines the principles of blood pressure, including normal and dysfunctional physiology, mathematical equations of pressure,
definitions of hypertension and diagnosis, and hence the rationale for and mechanisms ...
Leuschner, Machel; De Beer, N.; Schellack, Natalie(Medpharm Publications, 2023)
For drugs with a narrow therapeutic index (NTI) like tacrolimus, small changes in dosage can lead to significant changes in blood levels, which
can affect both the effectiveness of the drug and the risk of adverse effects. ...
Ncube, Keith Ntokozo; Nel, A.(Medpharm Publications, 2023)
Pharyngitis and tonsilitis are common reasons why people seek medical care. These diseases are commonly caused by viral and bacterial
infections, with group A β-haemolytic streptococcus being pharyngitis's most common ...
Pinzon, Rizaldy T.; Schellack, Natalie; Matawaran, Bien J.; Tsang, Man W.; Deerochanawong, Chaicharn; Hiew, Fu L.; Nafach, Jalal; Khadilkar, Satish(Association of Physicians of India, 2023-07)
INTRODUCTION : Peripheral neuropathy (PN) is an insidious disease that is often asymptomatic during the early stages but which can have a significant impact on quality of life at later stages when nerve damage occurs. There ...
Fick, Line; Crafford, Lucille; Schoeman, Johan P.; Schellack, Natalie(University of Toronto Press, 2024)
Antimicrobial resistance (AMR) has become a major global public health crisis due to inappropriate use in humans, animals, and crops. Studies to assess the knowledge and perceptions of antimicrobial stewardship (AMS) ...
INTRODUCTION : Antimicrobial resistance (AMR) is a global concern. Currently, the greatest mortality due to AMR is in Africa. A key driver continues to be high levels of dispensing of antibiotics without a prescription.
AREAS ...
BACKGROUND : In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic
exposures in patients with serious infections. These studies have led to the inclusion of dose optimization ...
The special themed issue; ‘Highlights of Basic and Clinical Pharmacology from Africa’ is a compilation of contributions from both basic and clinical research from the African continent. The publications included in this ...
Leuschner, Machel; Cromarty, Allan Duncan(MDPI, 2023-07-05)
Interethnic and interindividual variability in in vivo cytochrome P450 (CYP450)-dependent
metabolism and altered drug absorption via expressed transport channels such as P-glycoprotein
(P-gp) contribute to the adverse ...
OBJECTIVE : Retinoic acid (RA) is known to transition proliferating SH-SY5Y neuroblastoma cells towards functional
neurons. However, the activity of RA is restricted due to its photolability where any findings from prolonged ...
Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman(MDPI, 2023-05-19)
Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical
drug testing platforms, as they circumvent limitations associated with traditional monolayer cell
cultures. However, many of these ...
There are concerns with the current prescribing of antibiotics in both the private and
public primary care settings in South Africa. These concerns need to be addressed going forward
to reduce rising antimicrobial ...
BACKGROUND : The extension of medicine prescription rights to other healthcare providers was
proposed to reduce pharmacotherapeutic service delivery challenges in the South African
healthcare sector. The scope of practice ...
Maboko, Lerato Mamabote(University of Pretoria, 2023-08)
Alzheimer’s disease (AD) is the predominant form of dementia which primarily affects the elderly. To date the aetiology of AD has not been fully elucidated, though may include: loss of cholinergic transmission; excessive ...
BACKGROUND : Venomous snake bites have been listed as a neglected tropical disease by the World Health Organization. The Mozambique spitting cobra (Naja mossambica) is found in Sub-Saharan African countries, and its venom ...
BACKGROUND : The common cold is typically managed with decongestants, antihistamines, antitussives and antipyretics. In addition to these established medications, herbal ingredients have been used over centuries to help ...