OBJECTIVE : Retinoic acid (RA) is known to transition proliferating SH-SY5Y neuroblastoma cells towards functional
neurons. However, the activity of RA is restricted due to its photolability where any findings from prolonged ...
Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman(MDPI, 2023-05-19)
Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical
drug testing platforms, as they circumvent limitations associated with traditional monolayer cell
cultures. However, many of these ...
There are concerns with the current prescribing of antibiotics in both the private and
public primary care settings in South Africa. These concerns need to be addressed going forward
to reduce rising antimicrobial ...
BACKGROUND : The extension of medicine prescription rights to other healthcare providers was
proposed to reduce pharmacotherapeutic service delivery challenges in the South African
healthcare sector. The scope of practice ...
BACKGROUND : Venomous snake bites have been listed as a neglected tropical disease by the World Health Organization. The Mozambique spitting cobra (Naja mossambica) is found in Sub-Saharan African countries, and its venom ...
BACKGROUND : The common cold is typically managed with decongestants, antihistamines, antitussives and antipyretics. In addition to these established medications, herbal ingredients have been used over centuries to help ...
Since the emergence of COVID-19, several different medicines including antimicrobials have been administered to patients to treat COVID-19. This is despite limited evidence of the effectiveness of many of these, fueled by ...
There is an increasing focus across countries on researching the management of children admitted to hospital with COVID-19. This stems from an increasing prevalence due to new variants, combined with concerns with the ...
Ntuli, Sunday; Leuschner, M.; Bester, Megan; Serem, June Cheptoo(MDPI, 2022-06-14)
Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility. Encapsulation has been shown to overcome some of these limitations. A ...
Ivermectin is a well‐known and widely used anti‐parasitic drug. Recently, in vitro data suggest anti‐viral efficacy
of the drug, albeit at much higher concentrations than currently approved. Despite warnings by ...
Skosana, Phumzile; Schellack, Natalie; Godman, Brian; Kurdi, Amanj; Bennie, Marion; Kruger, Danie; Meyer, Johanna C.(Taylor and Francis, 2022)
OBJECTIVE : Up to 90% of antimicrobials globally are prescribed and dispensed in ambulatory care. However, there are considerable gaps regarding the extent and rationale for their use especially in low- and middle-income ...
Currently there is limited knowledge regarding antimicrobial utilization patterns among public hospitals in Eswatini. This is a concern given rising resistance rates among African countries. This study aimed to address ...
COVID-19-infected patients require an intact immune system to suppress viral replication
and prevent complications. However, the complications of SARS-CoV-2 infection that led to death
were linked to the overproduction ...
The capacity for social media to influence the utilization of re-purposed medicines to
manage COVID-19, despite limited availability of safety and efficacy data, is a cause for concern
within health care systems. This ...
OBJECTIVES : Nanomedicines represent theragnostic alternatives to traditional candidate drugs, with increased targeting and delivery potential due to their size and functional tailorability. Biological activity typically ...
As global health concerns become more complex, technological intervention is needed to achieve the Sustainable Development Goal. This study explores the use of the internet of things (IoT) and augmented reality (AR) ...
Acute wounds and injuries are a common daily occurrence, and their appropriate care is critical to healing. In South Africa, community
pharmacists are often the first to encounter acute wounds and injuries such as cuts, ...
Various types of wounds are encountered daily in medical practice, and due to the numerous treatment options available on the
market, making the most appropriate choice of treatment may be a rather daunting decision. The ...