• Synthesis, antibacterial, and cytotoxicity evaluation of oleanolic acid-4-aminoquinoline based hybrid compounds 

  Khwaza, Vuyolwethu; Oyedeji, Opeoluwa O.; Aderibigbe, Blessing A.; Morifi, Eric; Fonkui, Thierry Y.; Ndinteh, Derek T.; Steenkamp, Vanessa (Bentham Science, 2021-02)

  AIM : The study aims to prepare a class of oleanolic-based compounds. BACKGROUND : Conventional drugs used to treat infectious diseases suffer from limitations such as drug toxicity and drug resistance. The resistance ...
• Men and those with a history of smoking are associated with the development of postoperative ileus following elective colorectal cancer resection at a private academic hospital in Johannesburg, South Africa : a retrospective cohort study 

  Watkins, Estella L.; Schellack, Natalie; Abraham, Veena; Bebington, Brendan (Frontiers Media, 2021-06-15)

  INTRODUCTION : A scarcity of local published data on colorectal cancer (CRC) postoperative complications, including postoperative ileus (POI), exists. POI is a temporary gastrointestinal (GI) state of absent or reduced ...
• Using mystery shoppers to determine practices pertaining to antibiotic dispensing without a prescription among community pharmacies in South Africa—a pilot survey 

  Mokwele, R. Nelly; Schellack, Natalie; Bronkhorst, Elmien; Brink, Adrian J.; Schweickerdt, Louise; Godman, Brian (Oxford University Press, 2022-03)

  BACKGROUND : Inappropriate use of antimicrobials is a key factor increasing antimicrobial resistance, a major global public health problem including in South Africa. Key drivers include antibiotics being dispensed without ...
• Management of acute upper respiratory tract infection : the role of early intervention 

  Wang, De Yun; Eccles, Ronald; Bell, John; Chua, Antonio Hao; Salvi, Sundeep; Schellack, Natalie; Marks, Paulette; Wong, Yong Chiat (Taylor and Francis, 2021)

  INTRODUCTION : Upper respiratory tract infection (URTI) is an illness caused by an acute infection by viruses or bacteria of the nose, sinuses, pharynx, and larynx. Most URTIs are short, mild, and self-limiting, but some ...
• Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa 

  De Beer, Rene; Outhoff, Kim; Phulukdaree, Alisa; Soma, Prashilla (Taylor and Francis, 2021)

  Statins, the standard treatment for hypercholesterolaemia, among the most widely prescribed, have been associated with side effects, including statin intolerance. The aim of this study was to determine the background ...
• Antimicrobial stewardship activities in public healthcare facilities in South Africa : a baseline for future direction 

  Engler, Deirdre; Meyer, Johanna Catharina; Schellack, Natalie; Kurdi, Amanj; Godman, Brian (MDPI, 2021-08-17)

  Antimicrobial resistance (AMR) is a growing problem worldwide, including South Africa, where an AMR National Strategy Framework was implemented to instigate antimicrobial stewardship programmes (ASPs) and improve antimicrobial ...
• We survived 

  Cordier, Werner; Nyoni, Champion N. (Health and Medical Publishing Group, 2021-09)

  The COVID-19 pandemic reaffirms the need for the professionalisation of health professions education. The current higher education landscape in Africa privileges clinical competence over educational proficiency for educators ...
• Teaching pharmacology online : not just another narration 

  Cordier, Werner; Lubbe, J.C. (Irene) (Health and Medical Publishing Group, 2021-09)

  The COVID-19 pandemic placed educators in unique circumstances, not only due to their discipline- and student-specific considerations, but also their personal and professional milieu. Given a series of sudden ...
• Stimulating students' critical thinking skills in pharmacology using case report generation 

  Mlambo, Shamiso Shelter (Health & Medical Publishing Group, 2021-09)

  It is not a debatable issue that the COVID‑19 pandemic created several challenges in the education sector, and institutions across the world had to employ various interventions to ensure continuation of teaching and learning. ...
• Saving student interaction by saving the Starks 

  Parkar, Hafiza (Health and Medical Publishing Group, 2021-10)

  The pharmacology of antibacterials can be a tricky topic to lecture to students at any level. The cohort that we have is comprised of first-year medical students in their second semester, and teaching antibacterials at ...
• Zinc oxide nanoparticles induce oxidative stress and histopathological toxicity in the thyroid gland and liver of rats 

  Sakr, Samar; Steenkamp, Vanessa (Taylor and Francis, 2021)

  Zinc oxide nanoparticles are incorporated into cosmetics and sunscreens and are widely used in biomedical applications and the food industry. The increasing use of zinc oxide nanoparticles raises concerns about their safety. ...
• Underlying mechanisms of cytotoxicity in HepG2 hepatocarcinoma cells exposed to arsenic, cadmium and mercury individually and in combination 

  Cordier, Werner; Yousaf, Muhammad; Nell, Margo Judith; Steenkamp, Vanessa (Elsevier, 2021-04)

  BACKGROUND : Toxicity data regarding combinational exposure of humans to arsenic, cadmium and mercury is scarce. Although hepatotoxicity has been reported, limited information is available on their mechanistic underpinnings. ...
• COVID-19 and our crowning glory 

  Outhoff, Kim (Medpharm Publications, 2020-12-10)

  The inaugural issue of The South African General Practitioner (SAGP) is published in an unprecedented time of uncertainty, fear and a 21-day nationwide lockdown. The country is rallying to limit the spread of the spiky, ...
• Anaemia in chronic kidney disease – a review 

  Kok, Elandre (Medpharm Publications, 2020)

  The management of anaemia in chronic kidney disease (CKD) patients is a complex, multifaceted process reliant on the administration of exogenous erythropoiesis stimulating agents (ESAs) and iron supplements to ensure the ...
• Grommets - an update on common indications for tympanostomy tube placement 

  Outhoff, Kim (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2017)

  Children younger than 7 years are at increased risk of otitis media because of their immature immune systems and poorly functioning eustachian tubes that normally ventilate the middle ear space and equalize pressure with ...
• COVID-19 treatment : a growing (anti)body of evidence 

  Outhoff, Kim (Medpharm Publications, 2020-11)

  Our lives changed dramatically eight months ago when we went into a hard nationwide lockdown in a bid to limit the transmission of our new spiky foe, SARS-CoV-2. We endured the uncertainties of autumn, and then the winter ...
• The management of worsening heart failure 

  Ker, James A.; Outhoff, Kim (Medpharm Publications, 2020-07)

  Heart failure is a heterogeneous progressive syndrome of symptoms and signs, a culmination of structural and/or functional abnormalities of the heart. There is an elevated intracardiac pressure or reduced cardiac output ...
• Sick and tired of COVID-19 : long haulers and post viral (fatigue) syndromes 

  Outhoff, Kim (Medpharm Publications, 2020)

  COVID-19 patients may face a long and winding road to recovery. Outcomes of critically ill patients have been well described, including in China, Italy and the USA, and particularly in the comorbid elderly. However, short-, ...
• This too shall pass : coronaphobia and other fears 

  Outhoff, Kim (Medpharm Publications, 2020-06)

  “The heart's memory eliminates the bad and magnifies the good, and thanks to this artifice, we manage to endure the burden of the past.” Gabriel García Márquez, 1985, Love in the Time of Cholera.
• Wounds : an overlooked burden (Part 1) – Effective wound management starts with proper wound assessment 

  Parkar, Hafiza; Cromarty, Allan Duncan (Medpharm Publications, 2020-11)

  Healthcare professionals in general practice are tasked with treatment and management of wounds on a daily basis. The prognoses of these wounds are directly affected by the ability of the clinician to assess these wounds ...

View more