Research Articles (Pharmacology)

Research Articles (Pharmacology)

 

Recent Submissions

  • Marais, Andre; Osuch, E. (Medpharm Publications, 2020)
    Insomnia is an important public health burden and is the most ubiquitous sleep disorder in the general population, requiring accurate diagnosis and effective treatment. Sleep hygiene and cognitive behavioural therapy form ...
  • Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)
    β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
  • Marais, Andre (Plus 50 Media (Pty) Ltd, 2019-04)
    The 25th April is World Malaria Day and in this article ANDRé MARAIS tells us more about this disease, its cause and its prevention. Malaria is a common and potentially life-threatening disease in tropical and subtropical ...
  • Liebenberg, Jade; Du Toit-Prinsloo, Lorraine; Saayman, Gert; Steenkamp, Vanessa (Institute for Security Studies, 2019-03)
    Driving under the influence is a major threat to road safety in South Africa. Various psychoactive substances (both licit and illicit) have the potential to adversely affect driving performance and increase the probability ...
  • Lall, Namrita; Mahommodally, Mohamad Fawzi; Esposito, Debora; Steenkamp, Vanessa; Zengin, Gokhan; Steyn, Aimee; Oosthuizen, Carel Basson (Frontiers Media, 2020-07-29)
    The use of the word cosmetics comes from kosmétikos, an Ancient Greek term. This word can be translated as “skilled in adornment,” with the variant kosmein meaning “arrange” or “adorn” and kosmos meaning “order”: Further ...
  • Osuch, Elzbieta; Marais, Andre (Medpharm Publications, 2019)
    Depression affects nearly 350 million people worldwide. Local data indicates that approximately 17% of all South Africans will experience at least one episode of depression in their lifetime. Depressive disorders contribute ...
  • Osuch, E.; Marais, Andre (AOSIS Open Journals, 2019)
    Haemostasis and thrombosis rely on three components namely the vascular endothelial wall, blood platelets and the coagulation cascade. Non-physiologic excessive thrombosis occurs when haemostatic processes are dysfunctional, ...
  • Marais, Andre; Osuch, E.; Steenkamp, Vanessa; Ledwaba, L. (AOSIS Open Journals, 2019)
    In managing HIV/AIDS with highly active antiretroviral agents, the historical therapeutic aim remains to maintain the plasma concentrations at a level above the half maximal inhibitory concentration (IC50) required for ...
  • Outhoff, Kim (Medpharm Publications, NISC (Pty) and Cogent, Taylor and Francis Group, 2019)
    At some point in their career, at least a third of doctors suffer personal health problems such as injury, aging, or physical and mental illness, which detract from their ability to function properly and to practice ...
  • Ker, James A.; Outhoff, Kim (AOSIS Open Journals, 2019-07)
    Chronic heart failure is common, debilitating, and often the culmination of pervasive cardiovascular insults that systematically undermine the heart’s circulatory capacity and invoke counterproductive neuro-hormonal ...
  • Ker, James A.; Outhoff, Kim (OASIS, 2019-03)
    Globally more than 1 billion people have hypertension and it is predicted that because of ageing populations and increasing sedentary lifestyles, this figure will rise to about 1.5 billion by 2025. Elevated blood pressure ...
  • Ker, James A.; Outhoff, Kim (Medpharm Publications, 2019-12)
    In general, heart failure is the end-stage manifestation of cardiovascular disease and is an important and increasing cause of morbidity worldwide. Acute heart failure, whether of new onset or an exacerbation of chronic ...
  • Marais, Andre; Leuschner, M. (Medpharm Publications, NISC (Pty) and Cogent, Taylor and Francis Group, 2019-06)
    Acute sore throat is a common complaint encountered by medical practitioners and health care workers routinely. The disease is mostly caused by viral infections of the upper respiratory tract and is usually self-limiting. ...
  • Porchet, Hervé; Vidal, Virginie; Kornmann, Gabrielle; Malpass, Sam; Curtin, Francois (Elsevier, 2019-09)
    PURPOSE : Temelimab/GNbAC1 is a humanized immunoglobulin G4 monoclonal antibody antagonist of the human endogenous retrovirus W envelope protein, which is associated with multiple sclerosis (MS) pathophysiology and possibly ...
  • Fraser, Desiree Linda; Stander, Barend Andre; Steenkamp, Vanessa (Elsevier, 2019-08)
    As knowledge regarding mechanisms of pentachlorophenol (PCP) toxicity in neuronal cell lines is limited, the aim of the study was to evaluate the effects of PCP and its active metabolites, tetrachloro-1,4-benzoquinone ...
  • Aderibigbe, B.A.; Mugogodi, A.; Nwamadi, M.; Ray, S.S.; Steenkamp, Vanessa; Balogun, M.O.; Matshe, W.M.R. (Springer, 2020-05)
    Please read abstract in the article.
  • Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich C.; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. (ARKAT, 2018-09-09)
    A three-step synthesis, involving condensation of bromomethyl aryl ketones with urea to afford 2- aminothiazoles, their chloroacetylation and subsequent solvent-free Arbuzov phosphonation has afforded a series of novel ...
  • Gulumian, Mary; Yahaya, Ewura Seidu; Steenkamp, Vanessa (Hindawi, 2018-11-22)
    The use of traditional herbal remedies as alternativemedicine plays an important role in Africa since it forms part of primary health care for treatment of various medical conditions, including wounds. Although physiological ...
  • Greeff, O.B.W. (Oppel Bernhardt Wilhelm), 1948-; Van Tonder, Jacob John; Naidu, Kershlin; McMaster, Alicia; Van Tonder, Alet; Mothilal, Rashem (MedPharm Publications, 2018)
    Glucose clamp studies form an integral part of the early development of insulin therapies. Data generated in these studies are used to establish pharmacokinetic (PK) and pharmacodynamic (PD) profiles of the agents, but ...
  • Lepule, Keagile Hilda; Cordier, Werner; Steenkamp, Paul; Nell, Margo Judith; Steenkamp, Vanessa (Elsevier, 2019-11)
    Parkinson’s disease, characterised by loss of dopaminergic neurons in the substantia nigra of the brain, is attributed to oxidative stress and mitochondrial dysfunction. As no cure is available, and dopamine-replacement ...

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