Browsing Research Articles (Pharmacology) by Title

Browsing Research Articles (Pharmacology) by Title

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  • Stability, morphology, and effects of in vitro digestion on the antioxidant properties of polyphenol inclusion complexes with -cyclodextrin 
    Ntuli, Sunday; Leuschner, Machel; Bester, Megan; Serem, June Cheptoo (MDPI, 2022-06-14)
    Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility. Encapsulation has been shown to overcome some of these limitations. A ...
  • Stimulating students' critical thinking skills in pharmacology using case report generation 
    Mlambo, Shamiso Shelter (Health & Medical Publishing Group, 2021-09)
    It is not a debatable issue that the COVID‑19 pandemic created several challenges in the education sector, and institutions across the world had to employ various interventions to ensure continuation of teaching and learning. ...
  • Stress-related IBS 
    Outhoff, Kim (MedPharm Publications, 2016)
    The gastrointestinal tract is exquisitely sensitive to different physical and psychological stressors. Irritable bowel syndrome (IBS) may be viewed as a disorder caused by stress-induced dysregulation of the complex ...
  • A summary overview of the new, direct, target-specific oral anticoagulants 
    Muntingh, George L. (MedPharm Publications, 2016)
    In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC) or better referred to as direct oral anticoagulants (DOAC) or target-specific oral ...
  • Switching antidepressants 
    Outhoff, Kim (MedPharm Publications, 2015)
    Switching antidepressants because of lack of efficacy or unacceptable side-effects, while often required in general practice, may result in toxic drug-drug interactions, worsening depression or unpleasant discontinuation ...
  • Synthesis and biological evaluation of (E)-cinnamic acid, (E)-2-styrylthiazole and (E)-2-[2-(naphthalen-1-yl)vinyl]thiazole derivatives 
    Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. (Michigan Publishing, 2017-04)
    Cinnamyl- and thiazole-based compounds have been shown to exhibit diverse medicinal properties and a series of twelve (E)-2-styrylthiazole and (E)-2-[(naphthalen-1-yl)vinyl]thiazole derivatives, which are conjugates of ...
  • Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones 
    Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. (Elsevier, 2019-07)
    A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones have been prepared and shown to exhibit promising concentration-dependent activity against human SH-SY5Y cells, Plasmodium falciparum, ...
  • Synthesis and biological screening of diethyl [N-(thiazol-2-yl)carbamoyl]methylphosphonates 
    Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich C.; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. (ARKAT, 2018-09-09)
    A three-step synthesis, involving condensation of bromomethyl aryl ketones with urea to afford 2- aminothiazoles, their chloroacetylation and subsequent solvent-free Arbuzov phosphonation has afforded a series of novel ...
  • Synthesis, antibacterial, and cytotoxicity evaluation of oleanolic acid-4-aminoquinoline based hybrid compounds 
    Khwaza, Vuyolwethu; Oyedeji, Opeoluwa O.; Aderibigbe, Blessing A.; Morifi, Eric; Fonkui, Thierry Y.; Ndinteh, Derek T.; Steenkamp, Vanessa (Bentham Science, 2021-02)
    AIM : The study aims to prepare a class of oleanolic-based compounds. BACKGROUND : Conventional drugs used to treat infectious diseases suffer from limitations such as drug toxicity and drug resistance. The resistance ...
  • Targeting specific checkpoints in the management of SARS-CoV-2 induced cytokine storm 
    Abubakar, Abdullahi Rabiu; Ahmad, Rahnuma; Rowaiye, Adekunle Babajide; Rahman, Sayeeda; Iskandar, Katia; Dutta, Siddhartha; Oli, Angus Nnamdi; Dhingra, Sameer; Tor, Maryam Abba; Etando, Ayukafangha; Kumar, Santosh; Irfan, Mohammed; Gowere, Marshall; Chowdhury, Kona; Jahan, Dilshad; Schellack, Natalie; Haque, Mainul (MDPI, 2022-03-25)
    COVID-19-infected patients require an intact immune system to suppress viral replication and prevent complications. However, the complications of SARS-CoV-2 infection that led to death were linked to the overproduction ...
  • Teaching pharmacology online : not just another narration 
    Cordier, Werner; Lubbe, J.C. (Irene) (Health and Medical Publishing Group, 2021-09)
    The COVID-19 pandemic placed educators in unique circumstances, not only due to their discipline- and student-specific considerations, but also their personal and professional milieu. Given a series of sudden ...
  • This too shall pass : coronaphobia and other fears 
    Outhoff, Kim (Medpharm Publications, 2020-06)
    “The heart's memory eliminates the bad and magnifies the good, and thanks to this artifice, we manage to endure the burden of the past.” Gabriel García Márquez, 1985, Love in the Time of Cholera.
  • To clot, or not to clot –antithrombotic therapy is the question 
    Osuch, Elzbieta; Marais, Andre (AOSIS Open Journals, 2019)
    Haemostasis and thrombosis rely on three components namely the vascular endothelial wall, blood platelets and the coagulation cascade. Non-physiologic excessive thrombosis occurs when haemostatic processes are dysfunctional, ...
  • Toxicity profile of pyrrolizidine alkaloid-containing medicinal plants : Emphasis on Senecio species 
    Neuman, Manuela G.; Steenkamp, Vanessa (Global Science Books, 2009-12)
    Please read abstract in article.
  • Toxicity testing of two medicinal plants, Bridelia micrantha and Antidesma venosum 
    Steenkamp, Vanessa; Mokoele, T.L.; Jansen van Rensburg, Connie E. (Bentham Science, 2009)
    A. venosum and B. micrantha are widely used ethnomedically and B. micrantha has furthermore indicated the potential to be developed into a drug due to the various biological activities previously reported. However, the ...
  • Treatment of acute wounds and injuries : cuts, bites, bruises and sprains 
    Mlambo, Shamiso Shelter; Parkar, Hafiza; Naude, L.; Cromarty, Allan Duncan (Medpharm Publications, 2022)
    Acute wounds and injuries are a common daily occurrence, and their appropriate care is critical to healing. In South Africa, community pharmacists are often the first to encounter acute wounds and injuries such as cuts, ...
  • Treatment of the common cold with herbs used in Ayurveda and Jamu : monograph review and the science of ginger, liquorice, turmeric and peppermint 
    Wardani, Retno S.; Schellack, Natalie; Govender, Tamlyn; Dhulap, Abhay N.; Utami, Prapti; Malve, Vinod; Wong, Yong Chiat (Bioexcel Publishing, 2023-06)
    BACKGROUND : The common cold is typically managed with decongestants, antihistamines, antitussives and antipyretics. In addition to these established medications, herbal ingredients have been used over centuries to help ...
  • Trends in pharmacotherapy selection for the treatment of alcohol withdrawal in the Free State Province, South Africa 
    Van Zyl, P.M.; Gagiano, C.A.; Mollentze, W.F.; Snyman, J.S.; Joubert, G. (Psychological Society of South Africa, 2013-11)
    BACKGROUND. The selection of pharmacotherapy for the treatment of alcohol withdrawal remains a clinical challenge. Research continues into the underlying pathophysiology of dependence and withdrawal. A spectrum of clinical ...
  • Tricarbonyl(ŋ 6-flavone)chromium(0) 
    Van Tonder, Johannes H.; Bezuidenhoudt, Barend C.B.; Janse van Rensburg, J. Marthinus (International Union of Crystallography, 2009-11)
    In the title compound, [Cr(C15H10O2)(CO)3], the Cr(CO)3 unit exhibits a three-legged piano-stool conformation. The chromium metal centre is coordinated by the phenyl ring of the flavone ligand [Cr-(phenyl centroid) distance ...
  • Tricarbonyl(ŋ6-4′,7-dimethoxyiso-flavone) chromium(0) 
    Van Tonder, Johannes H.; Bezuidenhoudt, Barend C.B.; Janse van Rensburg, J. Marthinus (International Union of Crystallography, 2009)
    The metal atom of the Cr(CO)3 unit of the title compound, [Cr(C17H14O4)(CO)3], is coordinated to the methoxyphenyl ring of the isoflavone ligand; the Cr(CO)3 unit exhibits a three-legged piano-stool conformation. The ...