Browsing Research Articles (Nuclear Medicine) by Subject "Infection"

Browsing Research Articles (Nuclear Medicine) by Subject "Infection"

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  • EANM/SNMMI guideline for 18F-FDG use in inflammation and infection 
    Jamar, Francois; Buscombe, John Richard; Chiti, Arturo; Christian, Paul E.; Delbeke, Dominique; Donohoe, Kevin J.; Israel, Ora; Martin-Comin, Josep; Signore, Alberto (Society of Nuclear Medicine, Inc., 2013-01-28)
    The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology and practical application of nuclear ...
  • Imaging bacteria with radiolabelled probes : is it feasible? 
    Signore, Alberto; Artiko, Vera; Conserva, Martina; Ferro-Flores, Guillermina; Welling, Mick M.; Jain, Sanjay K.; Hess, Soren; Sathekge, Mike Machaba (MDPI, 2020-07-25)
    Bacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be di cult and delayed as well as the identification of the etiological pathogen, necessary for a tailored antibiotic ...
  • Imaging latent tuberculosis infection with radiolabeled nitroimidazoles 
    Ankrah, Alfred O.; Glaudemans, Andor W.J.M.; Sathekge, Mike Machaba; Klein, Hans C. (SpringerOpen, 2016-04)
    In a previous paper, an overview of the use of PET/CT in the management of tuberculosis (TB) was provided and the potential role of nitroimidazole imaging in LTBI was considered [1]. During latent TB, dormant bacilli ...
  • Insights into peptidoglycan-targeting radiotracers for imaging bacterial infections : updates, challenges, and future perspectives 
    Koatale, Palesa Caroline; Welling, Mick M.; Ndlovu, Honest; Kgatle, Mankgopo; Mdanda, Sipho; Mdlophane, Amanda; Okem, Ambrose; Takyi-Williams, John; Sathekge, Mike Machaba; Ebenhan, Thomas (American Chemical Society, 2024-02)
    The unique structural architecture of the peptidoglycan allows for the stratification of bacteria as either Gram-negative or Gram-positive, which makes bacterial cells distinguishable from mammalian cells. This classification ...
  • Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT 
    Sathekge, Mike Machaba; Garcia‑Perez, Osvaldo; Paez, Diana; El‑Haj, Noura; Kain‑Godoy, Taylor; Lawal, Ismaheel Opeyemi; Estrada‑Lobato, Enrique (Springer, 2018-01)
    OBJECTIVE : To determine the added value of CT over planar and SPECT-only imaging in the diagnosis of musculoskeletal infection using 99mTc-UBI 29-4. MATERIALS AND METHODS : 184 patients with suspected musculoskeletal ...
  • Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent 
    Ebenhan, Thomas; Mokaleng, Botshelo B.; Venter, Jacobus Daniel; Kruger, Hendrik Gert; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI Publishing, 2017-09)
    The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed ...
  • Preclinical evaluation of 68Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-ubiquicidin as a radioligand for PET infection imaging 
    Ebenhan, Thomas; Zeevaart, Jan Rijn; Venter, Jacobus D.; Govender, Thavendran; Kruger, Gert H.; Jarvis, Neil V.; Sathekge, Mike Machaba (Society of Nuclear Medicine, 2014-02)
    Antimicrobial peptides such as ubiquicidin (UBI) are believed to differentiate between mammalian and bacterial or fungal cells. (99m)Tc-UBI29-41 was previously tested for detecting infection in humans using SPECT. For the ...
  • Preclinical research highlighting contemporary targeting mechanisms of radiolabelled compounds for PET based infection imaging 
    Kleynhans, Janke; Sathekge, Mike Machaba; Ebenhan, Thomas (Elsevier, 2023-09)
    It is important to constantly monitor developments in the preclinical imaging arena of infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be identified to funnel into the clinic. Secondly, ...
  • Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection 
    Dutta, Jyotibon; Baijnath, Sooraj; Somboro, Anou M.; Nagiah, Savania; Albericio, Fernando; De la Torre, Beatriz G.; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Kruger, Hendrik G.; Chuturgoon, Anil; Naicker, Tricia; Ebenhan, Thomas; Govender, Thavendran (Wiley, 2017-10)
    Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the ...