Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent
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Date
Authors
Ebenhan, Thomas
Mokaleng, Botshelo B.
Venter, Jacobus Daniel
Kruger, Hendrik Gert
Zeevaart, Jan Rijn
Sathekge, Mike Machaba
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI Publishing
Abstract
The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its
potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled
DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2) rabbits bearing
muscular sterile inflammation and Staphylococcus aureus (SA) infection; and (NZR3) rabbits
infected with Mycobacterium tuberculosis (MTB) combined with a subcutaneous scruff infection
of SA in the same animal. All animals were imaged using a PET/CT scanner at 5 and 60 min
post injection. Images showed elevated accumulation of 68Ga-DOTA-TBIA101 in the sterile
muscular inflammation site (T/NT ratio = 2.6 0.37 (5 min) and 2.8 2.3 (60 min)) and
muscles infected with MTB (T/NT ratio = 2.6 0.35 (5 min) and 2.8 0.16 (60 min)). The findings
suggest that 68Ga-DOTA-TBIA101-PET/CT may detect MTB-associated inflammation, although more
foundational studies need to be performed to rationalize the diagnostic value of this technique.
Description
Keywords
DOTA-TBIA101, Depsipeptides, Infection, Inflammation, 68Ga/68Ge generator, PET/CT imaging, Tuberculosis (TB)
Sustainable Development Goals
Citation
Ebenhan, T., Mokaleng, B.B., Venter, J.D., Kruger, H.G., Zeevaart, J.R. & Sathekge, M. 2017, 'Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent', Molecules, vol. 22, no. 9, art. no. 1403, pp. 1-14.