Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly
expressed in almost all prostate cancers. By playing such a universal role in the disease,
PSMA provides a target for diagnostic imaging of ...
Sathekge, Mike Machaba; Maes, Alex; Pottel, Hans; Stoltz, Anton Carel; Van de Wiele, Christophe(Health and Medical Publishing Group, 2010-09)
OBJECTIVE: Fluorodeoxyglucose (FDG)-positron emission tomography
(PET) is an accurate non-invasive imaging test for differentiating
benign from malignant solitary pulmonary nodules (SPNs). We
aimed to assess its diagnostic ...
Jamar, Francois; Buscombe, J.R. (John Richard); Chiti, Arturo; Christian, Paul E.; Delbeke, Dominique; Donohoe, Kevin J.; Israel, Ora; Martin-Comin, Josep; Signore, Alberto(Society of Nuclear Medicine, Inc., 2013-01-28)
The Society of Nuclear Medicine and Molecular Imaging
(SNMMI) is an international scientific and professional
organization founded in 1954 to promote the science,
technology and practical application of nuclear ...
Vorster, Mariza; Maes, Alex; Jacobs, Aldrich; Malefahlo, Sidney; Pottel, Hans; Van de Wiele, Christophe; Sathekge, Mike Machaba(Springer, 2014-07)
We sought to determine whether PET/CT
imaging with 68Ga-citrate could be of value in distinguishing
benign from malignant lung pathology in a setting
with a high prevalence of granulomatous diseases.
METHODS : ...
Ebenhan, Thomas; Schoeman, Isabel; Rossouw, Daniel D.; Grobler, Anne; Marjanovic-Painter, Biljana; Wagener, Judith; Kruger, Hendrik G.; Sathekge, Mike Machaba; Zeevaart, Jan Rijn(Springer, 2017-06)
PURPOSE : Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating ...
Sathekge, Mike Machaba; Maes, Alex; Kgomo, Mbo; Stoltz, Anton Carel; Ankrah, Alfred O.; Van de Wiele, Christophe(Lippincott Williams & Wilkins, 2010)
OBJECTIVE: To evaluate differences in glucose uptake by skeletal muscle tissue and subcutaneous fat in HIV patients on HAART (highly active antiretroviral therapy)
presenting with and without lipodystrophy as well as in ...
Buscombe, J.R. (John Richard)(British Institute of Radiology, 2015)
Positron emission tomography (PET) has become widely established in oncology. Subsequently, a whole new “toolbox” of
tracers have become available to look at different aspects of cancer cell function and dysfunction, ...
Sathekge, Mike Machaba; Maes, Alex; Van de Wiele, Christophe(Elsevier, 2013-09)
The intersection and syndemic interaction between the human immunodeficiency virus (HIV)
and tuberculosis (TB) epidemics have global prevalence with devastatingmorbidity andmassive
mortality. Using FDG-PET imaging it was ...
Lawal, Ismaheel; Lengana, Thabo; Janse van Rensburg, Charl; Reyneke, Florette; Popoola, Gbenga O.; Ankrah, Alfred O.; Sathekge, Mike Machaba(Public Library of Science, 2019-04-18)
OBJECTIVES : To determine the impact of FDG-PET/CT in the initial staging of cervical cancer among
women with and without HIV and to determine the abilities of FDG-PET/CT metabolic
parameters in predicting the presence ...
Madiba, Thandinkosi E.; Awotedu, Abolade A.; Du Plessis, Dion; Nchabeleng, Maphoshane; Sathekge, Mike Machaba; Velaphi, Sithembiso C.; Volmink, Jimmy A.; Walubo, Andrew; Mayosi, Bongani M.(Health and Medical Publishing Group, 2012-01)
The Hamilton Naki Scholarship was introduced because of the shortage of qualified academic leaders in South African medical schools, especially for academic clinicians from previously disadvantaged backgrounds. There were ...
Ankrah, Alfred O.; Glaudemans, Andor W.J.M.; Sathekge, Mike Machaba; Klein, Hans C.(SpringerOpen, 2016-04)
In a previous paper, an overview of the use of PET/CT in
the management of tuberculosis (TB) was provided and the
potential role of nitroimidazole imaging in LTBI was
considered . During latent TB, dormant bacilli ...
Sathekge, Mike Machaba; Maes, Alex; Kgomo, Mbo; Stoltz, Anton Carel; Pottel, Hans; Van de Wiele, Christophe(Schattauer, 2010)
The AIM: of this study is to assess the potential
impact of double-phase FDG PET versus routine
staging in HIV-negative patients suffering
from tuberculosis. PATIENTS, METHODS: 16 consecutive
patients suffering from ...
Bracke, Nathalie; Yao, Han; Wynendaele, Evelien; Verbeke, Frederick; Xu, Xiaolong; Gevaert, Bert; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Saeger, Sarah; De Spiegeleer, Bart(American Chemical Society, 2017-03)
Chemical modifications on protein biopharmaceuticals introduce extra variability in addition to their inherent complexity, hence require more comprehensive analytical and functional characterization during their discovery, ...
Lawal, Ismaheel; Vorster, Mariza; Boshomane, Tebatso; Ololade, Kehinde; Ebenhan, Thomas; Sathekge, Mike Machaba(Lippincott Williams and Wilkins, 2015-09)
We describe the finding of a metastatic superscan detected by Ga-PSMA PET/CT imaging. A 63-year-old man with metastatic prostate carcinoma underwent Ga-PSMA PET/CT imaging for staging and evaluation of the most appropriate ...
Ankrah, Alfred O.; Klein, Hans C.; Elsinga, Philip H.(Bentham Science, 2018)
Diabetic Foot Infections (DFIs) are associated with increased morbidity, an economic burden on patients, their families and healthcare systems and increased mortality. Early diagnosis with prompt, appropriate and adequate ...
Bone metastases, often a consequence of breast, prostate, and lung carcinomas, are
characterized by an increased bone turnover, which can be visualized by positron emission
tomography (PET), as well as single-photon ...
Nyakale, Nozipho E.; Lockhat, Zarina I.(Allergy Society of South Africa, 2015-03)
Immunologic reactions to radiopharmaceuticals are usually mild and transient and require little or no medical
treatment. As the usage of radiopharmaceuticals has increased, the reported adverse reactions remain ...
Ebenhan, Thomas; Chadwick, Nicholas; Sathekge, Mike Machaba; Govender, Patrick; Govender, Thavendran; Kruger, Hendrik G.; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn(Elsevier, 2014-05)
Human antimicrobial peptides are of interest for the development of positron emission tomography (PET) tracers as they exhibit desirable characteristics that make them good candidates for targeting vectors. ...
Warwick, J.M.; Sathekge, Mike Machaba(Elsevier, 2011-04)
Positron emission tomography (PET) with [F-18]-fluoro-deoxy-glucose (FDG) has a well
established and growing role in the management of most lymphomas. The interpretation
of FDG PET scans in HIV positive patients is however ...