Characterization of FDG PET images using texture analysis in tumors of the gastro-intestinal tract : a review

Loading...
Thumbnail Image

Authors

Deleu, Anne-Leen
Sathekge, Machaba Junior
Maes, Alex
De Spiegeleer, Bart
Sathekge, Mike Machaba
Van de Wiele, Christophe

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

Radiomics or textural feature extraction obtained from positron emission tomography (PET) images through complex mathematical models of the spatial relationship between multiple image voxels is currently emerging as a new tool for assessing intra-tumoral heterogeneity in medical imaging. In this paper, available literature on texture analysis using FDG PET imaging in patients suffering from tumors of the gastro-intestinal tract is reviewed. While texture analysis of FDG PET images appears clinically promising, due to the lack of technical specifications, a large variability in the implemented methodology used for texture analysis and lack of statistical robustness, at present, no firm conclusions can be drawn regarding the predictive or prognostic value of FDG PET texture analysis derived indices in patients suffering from gastro-enterologic tumors. In order to move forward in this field, a harmonized image acquisition and processing protocol as well as a harmonized protocol for texture analysis of tumor volumes, allowing multi-center studies excluding statistical biases should be considered. Furthermore, the complementary and additional value of CT-imaging, as part of the PET/CT imaging technique, warrants exploration.

Description

Keywords

Radiomics, Gastro-intestinal cancer, Textural feature extraction, Positron emission tomography (PET), Intra-tumoral heterogeneity, Medical imaging, Fluorodeoxyglucose-positron emission tomography (FDG PET)

Sustainable Development Goals

Citation

Deleu, A-L., Sathekge, M.J., Maes, A. et al. 2020, 'Characterization of FDG PET images using texture analysis in tumors of the gastro-intestinal tract: a review', BioMedicines, vol. 8, no. 9, art. 304, pp. 1-13.