Browsing Nuclear Medicine by Author "De Spiegeleer, Bart"

Browsing Nuclear Medicine by Author "De Spiegeleer, Bart"

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  • Analytical characterization of NOTA-modified somatropins 
    Bracke, Nathalie; Wynendaele, Evelien; D’Hondt, Matthias; Haselberg, Rob; Somsen, Govert W.; Pauwels, Ewald; Van de Wiele, Christophe; De Spiegeleer, Bart (Elsevier, 2014-08)
    Chemical modification of biomolecules like the introduction of metal-chelators into proteins can lead to heterogeneous product formation. The nature and extend of the modification is important in interpreting the biological ...
  • Biological characterisation of somatropin-derived cryptic peptides 
    Tack, Liesa; Bracke, Nathalie; Verbeke, Frederick; Wynendaele, Evelien; Pauwels, Ewald; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Spiegeleer, Bart (Springer, 2019-09)
    Little is known about possible cryptic peptides of the recombinant growth hormone (somatropin). In this study, six synthetic somatropin-derived peptides (SDPs) were selected based on their sequences which correspond to the ...
  • Characterization of FDG PET images using texture analysis in tumors of the gastro-intestinal tract : a review 
    Deleu, Anne-Leen; Sathekge, Machaba Junior; Maes, Alex; De Spiegeleer, Bart; Sathekge, Mike Machaba; Van de Wiele, Christophe (MDPI, 2020-08)
    Radiomics or textural feature extraction obtained from positron emission tomography (PET) images through complex mathematical models of the spatial relationship between multiple image voxels is currently emerging as a ...
  • Crosstalk between the microbiome and cancer cells by quorum sensing peptides 
    Wynendaele, Evelien; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Van de Wiele, Christophe; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; De Spiegeleer, Bart (Elsevier, 2015-02)
    To date, the precise role of the human microbiome in health and disease states remains largely undefined. Complex and selective crosstalk systems between the microbiome and mammalian cells are also not yet reported. ...
  • In vitro functional quality characterization of NOTA-modified somatropins 
    Bracke, Nathalie; Yao, Han; Wynendaele, Evelien; Verbeke, Frederick; Xu, Xiaolong; Gevaert, Bert; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Saeger, Sarah; De Spiegeleer, Bart (American Chemical Society, 2017-03)
    Chemical modifications on protein biopharmaceuticals introduce extra variability in addition to their inherent complexity, hence require more comprehensive analytical and functional characterization during their discovery, ...
  • PSMA-targeting positron emission agents for imaging solid tumors other than non-prostate carcinoma : a systematic review 
    Van de Wiele, Christophe; Sathekge, Mike Machaba; De Spiegeleer, Bart; De Jonghe, Pieter Jan; Beels, Laurence; Maes, Alex (MDPI Publishing, 2019-10-02)
    Despite its name, prostate-specific membrane antigen (PSMA) has been shown using immunohistochemistry (IHC) to also be over-expressed in the tumor neovasculature of a wide variety of solid tumors other than prostate ...
  • The quorum sensing peptides PhrG, CSP and EDP promote angiogenesis and invasion of breast cancer cells in vitro 
    De Spiegeleer, Bart; Verbeke, Frederick; D’Hondt, Matthias; Hendrix, An; Van de Wiele, Christophe; Burvenich, Christian; Peremans, Kathelijne; De Wever, Olivier; Bracke, Marc; Wynendaele, Evelien (Public Library of Science, 2015-03-17)
    The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated the influence of some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, on ...