Browsing Research Articles (Immunology) by Title

Browsing Research Articles (Immunology) by Title

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  • The COVID-19 treatment landscape : a South African perspective on a race against time 
    Hendricks, Candice Laverne; Herd, Candice Lee; Nel, Marcel; Tintinger, Gregory Ronald; Pepper, Michael Sean (Frontiers Media, 2021-02-19)
    The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which ...
  • CRISPR-Cas : revolutionising genome engineering 
    Nicholson, S.A.; Pepper, Michael Sean (Health and Medical Publishing Group, 2016-09)
    The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome ...
  • Culex pipiens as a potential vector for transmission of Dirofilaria immitis and other unclassified Filarioidea in Southwest Spain 
    Bravo-Barriga, Daniel; Parreira, Ricardo; Almeida, Antonio Paulo Gouveia; Calado, Manuela; Blanco-Ciudad, Juan; Serrano-Aguilera, Francisco Javier; Pérez-Martín, Juan Enrique; Sánchez-Peinado, Joaquín; Pinto, João; Reina, David; Frontera, Eva (Elsevier, 2016-06)
    Dirofilaria immitis is one of the most frequently detected mosquito-transmitted zoonotic filarioid nematode in mammals in Europe, being canine dirofilariosis a major animal health problem, endemic in the Mediterranean ...
  • Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models 
    Sempa, Joseph B.; Rossouw, Theresa M.; Lesaffre, Emmanuel; Nieuwoudt, Martin (Public Library of Science, 2019-11-13)
    INTRODUCTION : There are Challenges in statistically modelling immune responses to longitudinal HIV viral load exposure as a function of covariates. We define Bayesian Markov Chain Monte Carlo mixed effects models to ...
  • Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function 
    Theron, Annette J.; Steel, Helen C.; Tintinger, Gregory Ronald; Gravett, Cornelia M.; Anderson, Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014)
    Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, ...
  • Cystic fibrosis in South Africa : a changing diagnostic paradigm 
    Van Rensburg, J.; Alessandrini, Marco; Stewart, Cheryl; Pepper, Michael Sean (Health and Medical Publishing Group, 2018-08)
    Cystic fibrosis (CF), one of the most commonly observed and diagnosed fatal monogenic disorders globally, was initially thought to affect individuals of Caucasian/European descent almost exclusively. It is increasingly ...
  • Cystic fibrosis in the African diaspora 
    Stewart, Cheryl; Pepper, Michael Sean (American Thoracic Society, 2017-01)
    Identifying mutations that cause cystic fibrosis (CF) is important for making an early, unambiguous diagnosis, which, in turn, is linked to better health and a greater life expectancy. In patients of African descent, a ...
  • Cystic fibrosis on the African continent 
    Stewart, Cheryl; Pepper, Michael Sean (Nature Publishing Group, 2016-07)
    Cystic fibrosis (CF; OMIM 219700) is a life-shortening and costly autosomal recessive disease that has been most extensively studied in individuals of Caucasian descent. There is ample evidence, however, that it also affects ...
  • A data management plan for the NESHIE observational study 
    Strydom, Adele; Van Rensburg, Jeanne; Pepper, Michael Sean (Frontiers Media, 2023-12-06)
    With regard to the use and transfer of research participants’ personal information, samples and other data nationally and internationally, it is necessary to construct a data management plan. One of the key objectives ...
  • Deaths from bee stings : a report of three cases from Pretoria, South Africa 
    Du Toit-Prinsloo, Lorraine; Morris, Neil Kenneth; Meyer, Pieter Willem Adriaan; Saayman, Gert (Springer, 2016-03)
    In South Africa bee stings are most commonly caused by either Apis mellifera capensis or A. mellifera scutellata, indigenous species which are notoriously aggressive when compared to European honey bees. According to ...
  • Decline in antibody responses to SARS-CoV-2 post-vaccination poses a risk to health care workers 
    Worsley, Catherine M.; Van der Mescht, Mieke Adri; Hoffmann, Daniel; Meyer, Pieter Willem Adriaan; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2022-09)
    No abstract available.
  • The deep genome project 
    Lloyd, K.C. Kent; Adams, David J.; Baynam, Gareth; Beaudet, Arthur L.; Bosch, Fatima; Boycott, Kym M.; Braun, Robert E.; Caulfield, Mark; Cohn, Ronald; Dickinson, Mary E.; Dobbie, Michael S.; Flenniken, Ann M.; Flicek, Paul; Galande, Sanjeev; Gao, Xiang; Grobler, Anne; Heaney, Jason D.; Herault, Yann; Hrabe de Angelis, Martin; Lupski, James R.; Lyonnet, Stanislas; Mallon, Ann-Marie; Mammano, Fabio; MacRae, Calum A.; McInnes, Roderick; McKerlie, Colin; Meehan, Terrence F.; Murray, Stephen A.; Nutter, Lauryl M.J.; Obata, Yuichi; Parkinson, Helen; Pepper, Michael Sean; Sedlacek, Radislav; Seong, Je Kyung; Shiroishi, Toshihiko; Smedley, Damian; Tocchini-Valentini, Glauco; Valle, David; Leo Wang, Chi-Kuang; Wells, Sara; White, Jacqueline; Wurst, Wolfgang; Xu, Ying; Brown, Steve D.M. (BioMed Central, 2020-02-03)
    In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, ...
  • Deoxyribonucleic acid damage and repair : capitalizing on our understanding of the mechanisms of maintaining genomic integrity for therapeutic purposes 
    Helena, Jolene Michelle; Joubert, Anna Margaretha; Grobbelaar, Simone; Nolte, Elsie Magdalena; Nel, Marcel; Pepper, Michael Sean; Coetzee, Magdalena; Mercier, Anne Elisabeth (MDPI Publishing, 2018-04-11)
    Deoxyribonucleic acid (DNA) is the self-replicating hereditary material that provides a blueprint which, in collaboration with environmental influences, produces a structural and functional phenotype. As DNA coordinates ...
  • Dermatologic immune-related adverse events : the toxicity spectrum and recommendations for management 
    Apalla, Zoe; Rapoport, Bernardo Leon; Sibaud, Vincent (Elsevier, 2021-12)
    Immune checkpoint inhibitors are a new class of oncologic drugs that act via the inhibition of check- points, thereby unlocking the immune system to attack cancer cells. Their emergence has radically changed the concept ...
  • Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination 
    Motsoeneng, Boitumelo M.; Manamela, Nelia; Kaldine, Haajira; Kgagudi, Prudence; Hermanus, Tandile; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Van der Mescht, Mieke Adri; Abdullah, Fareed; Boswell, Michael; Ueckermann, Veronica; Rossouw, Theresa; Madhi, Shabir A.; Moore, Penny L.; Richardson, Simone I. (Frontiers Media, 2023-08-03)
    The kinetics of Fc-mediated functions following SARS-CoV-2 infection or vaccination in people living with HIV (PLWH) are not known. We compared SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in ...
  • The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis 
    Hodkinson, Bridget; Meyer, Pieter Willem Adriaan; Musenge, Eustasius; Ally, Mahmood Moosa Tar Mahomed; Wadee, Ahmed A.; Anderson, Ronald; Tikly, Mohammed (Springer, 2010-02)
    To establish the diagnostic utility of the anticyclic- citrullinated peptide antibody (aCCP) test in Black South Africans with early rheumatoid arthritis (RA). A cross-sectional study comparing the rheumatoid factor ...
  • Diagnostic utility of, and influence of tobacco usage and genetic predisposition on, immunoglobulin A, rheumatoid factor and anti-citrullinated peptide auto-antibodies in South African rheumatoid arthritis patients 
    Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Anderson, Ronald; Tikly, Mohammed (Makerere University Medical School, 2018-06)
    BACKGROUND : The immunoglobulin A isotypes of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) are associated with disease severity and progression in Caucasian rheumatoid arthritis (RA) ...
  • Differential responsiveness of the platelet biomarkers, systemic CD40 ligand, CD62P, and platelet-derived growth factor-BB, to virally-suppressive antiretroviral therapy 
    Steel, Helen C.; Venter, Willem Daniel Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Arulappan, Natasha; Rossouw, Theresa M. (MDPI, 2021-01-29)
    Systemic biomarkers of inflammation, including cytokines and chemokines, are potentially useful in the management of both HIV infection and non-AIDS-defining disorders. However, relatively little is known about the utility ...
  • Dilute Russel viper venom time analysis in a haematology laboratory : an audit 
    Kruger, Welma; Meyer, Pieter Willem Adriaan; Nel, Jan Gert (Wiley, 2018-08)
    INTRODUCTION : To determine whether the current set of evaluation criteria used for dilute Russel Viper Venom Time (dRVVT) investigations in the routine laboratory meet expectation and identify possible shortcomings. METHODS ...
  • Discrepancies between clinical diagnoses and autopsy findings : a comparative study conducted in South Africa 
    Joubert, Doret M.; Rossouw, Servaas Hofmeyr; Solomon, C.; Meyer, Pieter Willem Adriaan (Health and Medical Publishing Group, 2022-11)
    BACKGROUND. The anatomical pathology autopsy serves several purposes, notably as a quality management tool for evaluation of accuracy in clinical diagnosis. Despite its value, for various reasons there has been an ...