• Revealing the indispensable role of the RFamide functionality using a novel acid labile benzofuranone based amine (ALBA) linker 

  Mudd, Gemma; Hendrikse, Megan; Shave, Steven; Houston, Douglas R.; Millar, Robert P.; Auer, Manfred (Wiley, 2024-04)

  The RFamide family of peptides represents an important class of GPCR ligand neuropeptides covering a wide range of biological functions. While many analogues of the highly conserved C-terminal RFamide motif within this ...
• Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3 

  Rapoport, Bernardo Leon; Steel, Helen C.; Benn, Carol A.; Nayler, Simon; Smit, Teresa; Heyman, Liezl; Theron, Annette J.; Hlatshwayo, Nomsa; Kwofie, Luyanda Laura Illicia; Meyer, P.W.A. (Pieter Willem Adriaan); Anderson, Ronald (Frontiers Media, 2023-03-30)

  Neoadjuvant chemotherapy (NAC) may alter the immune landscape of patients with early breast cancer (BC), potentially setting the scene for more effective implementation of checkpoint-targeted immunotherapy. This issue ...
• Spatial analyses of immune cell infiltration in cancer : current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer 

  Page, David B.; Broeckx, Glenn; Jahangir, Chowdhury Arif; Verbandt, Sara; Gupta, Rajarsi R.; Thagaard, Jeppe; Khiroya, Reena; Kos, Zuzana; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Almeida, Jonas S.; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R.M.; Botinelly Mendonca Fujimoto, Luciana; Burgues, Octavio; Cheang, Maggie Chon U.; Ciompi, Francesco; Cooper, Lee A.D.; Coosemans, An; Corredor, German; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N.; Elghazawy, Mahmoud; Ely, Scott; Fernandez-Martin, Claudio; Fineberg, Susan; Fox, Stephen B.; Gallagher, William M.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez-Ericsson, Paula I.; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hardas, Alexandros; Hart, Steven N.; Hartman, Johan; Hewitt, Stephen; Hida, Akira I.; Horlings, Hugo M.; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel A.M.; Kahila, Mohamed; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I.; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Kovacs, Aniko; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K.; Manur Narasimhamurthy, Vidya; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Reis-Filho, Jorge S.; Ribeiro, Joana M.; Rimm, David; Salomon, Anne-Vincent; Salto-Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; Van Der Laak, Jeroen; Van Diest, Paul J.; Verghese, Gregory E.; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Adams, Sylvia; Bartlett, John Mark Seaverns; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Specht Stovgaard, Elisabeth; Akturk, Guray; Bouchmaa, Najat (Wiley, 2023-08)

  Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized ...
• Editorial : the immunological role of platelet activation in the pathophysiology of COVID-19 

  Rossouw, Theresa; Pretorius, Etheresia; Wool, Geoffrey D. (Frontiers Media, 2023-09)

  Platelets are increasingly recognized for their role as mediators of immune response and inflammation. As major components of the hematological system, they form an important bridge between immunity and coagulation. When ...
• A data management plan for the NESHIE observational study 

  Strydom, Adele; Van Rensburg, Jeanne; Pepper, Michael Sean (Frontiers Media, 2023-12-06)

  With regard to the use and transfer of research participants’ personal information, samples and other data nationally and internationally, it is necessary to construct a data management plan. One of the key objectives ...
• Comparison of platelet-and endothelial-associated biomarkers of disease activity in people hospitalized with Covid-19 with and without HIV co-infection 

  Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa (Frontiers Media, 2023-08-14)

  INTRODUCTION : SARS-CoV-2 elicits a hyper-inflammatory response that contributes to increased morbidity and mortality in patients with COVID-19. In the case of HIV infection, despite effective anti-retroviral therapy, ...
• Consequences of HIV infection in the bone marrow niche 

  Herd, Candice; Mellet, Juanita; Mashingaidze, Nester; Durandt, Chrisna; Pepper, Michael Sean (Frontiers Media, 2023-07-11)

  Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular ...
• Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination 

  Motsoeneng, Boitumelo M.; Manamela, Nelia; Kaldine, Haajira; Kgagudi, Prudence; Hermanus, Tandile; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Van der Mescht, Mieke Adri; Abdullah, Fareed; Boswell, Michael; Ueckermann, Veronica; Rossouw, Theresa; Madhi, Shabir A.; Moore, Penny L.; Richardson, Simone I. (Frontiers Media, 2023-08-03)

  The kinetics of Fc-mediated functions following SARS-CoV-2 infection or vaccination in people living with HIV (PLWH) are not known. We compared SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in ...
• From Africa with love : a festschrift for Robert P. Millar 

  Ludwig, Mike; Newton, Claire L. (Wiley, 2024)

  Robert (Bob) Millar will retire in 2024, after a long and distinguished career in neuroendocrinology. Claire and I have been working with Bob for some years and took on the task of organising a Festschrift to celebrate his ...
• Comparison of the effects of electronic cigarette vapours and tobacco smoke extracts on human neutrophils in vitro 

  Richards, G.A.; Theron, Annette J.; Van den Bout, Jan Iman; Anderson, Ronald; Feldman, Charles; Van Zyl Smit, Richard; Chang, Ju-Wei; Tintinger, Gregory (European Respiratory Society, 2023-05)

  BACKGROUND : Electronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered safer than ...
• Relationships of emerging biomarkers of cancer cachexia with quality of life, appetite, and cachexia 

  Lipshitz, Melanie; Visser, J.; Anderson, Ronald; Nel, D.G.; Smit, T.G. (Theunis); Steel, Helen C.; Rapoport, Bernardo Leon (Springer, 2024-05)

  PURPOSE : Quality of life (QoL), appetite, cachexia, and biomarkers [albumin, hemoglobin (Hb), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), ...
• Tachykinin receptor-selectivity of the potential glioblastoma-targeted therapy, DOTA-[Thi8,Met(O2)11]-substance P 

  Suthiram, Janine; Pieters, Ane; Moosa, Zulfiah Mohamed; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Ebenhan, Thomas; Anderson, Ross Calley; Newton, Claire L. (MDPI, 2023-01)

  Please read abstract in article.
• The global burden of community-acquired pneumonia in adults, encompassing invasive pneumococcal disease and the prevalence of its associated cardiovascular events, with a focus on pneumolysin and macrolide antibiotics in pathogenesis and therapy 

  Anderson, Ronald; Feldman, Charles (MDPI, 2023-07)

  Despite innovative advances in anti-infective therapies and vaccine development technologies, community-acquired pneumonia (CAP) remains the most persistent cause of infection-related mortality globally. Confronting the ...
• Pro-tumorigenic and thrombotic activities of platelets in lung cancer 

  Anderson, Ronald; Rapoport, Bernardo Leon; Steel, Helen C.; Theron, Annette J. (MDPI, 2023-07)

  Aside from their key protective roles in hemostasis and innate immunity, platelets are now recognized as having multifaceted, adverse roles in the pathogenesis, progression and outcome of many types of human malignancy. ...
• Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model 

  Peta, Kimberly; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2023-10)

  The prevalence of breast cancer (BC) continues to increase and is the leading cause of cancer deaths in many countries. Numerous in vitro and in vivo studies have demonstrated that 2‐methoxyestradiol (2‐ME) has ...
• Role of Neurokinin B in gametogenesis and steroidogenesis of freshwater catfish, Clarias batrachus 

  Singh, Ankur; Lal, Bechan; Kumar, Pankaj; Parhar, Ishwar S.; Millar, Robert P. (Springer, 2023-08)

  Neurokinin B (NKB), a recently discovered neuropeptide, plays a crucial role in regulating the kiss-GnRH neurons in vertebrate's brain. NKB is also characterized in gonadal tissues; however, its role in gonads is poorly ...
• How nuclear envelope dynamics can direct laminopathy phenotypes 

  Van Heerden, David; Klima, Stefanie; Van den Bout, Iman (Elsevier, 2024-02)

  The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The ...
• Role of clock genes and circadian rhythm in renal cell carcinoma : recent evidence and therapeutic consequences 

  Santoni, Matteo; Molina-Cerrillo, Javier; Santoni, Giorgio; Lam, Elaine T.; Massari, Francesco; Mollica, Veronica; Mazzaschi, Giulia; Rapoport, Bernardo Leon; Grande, Enrique; Buti, Sebastiano (MDPI, 2023-01-07)

  Circadian rhythm regulates cellular differentiation and physiology and shapes the immune response. Altered expression of clock genes might lead to the onset of common malignant cancers, including Renal Cell Carcinoma ...
• 2023 updated MASCC/ESMO consensus recommendations: controlling nausea and vomiting with chemotherapy of low or minimal emetic potential 

  Olver, Ian; Clark-Snow, Rebecca; Ruhlmann, Christina H.; Garcia-del-Barrio, Maria-Angeles; Schwartzberg, Lee; Rapoport, Bernardo Leon; Jahn, Franziska (Springer, 2024-01)

  PURPOSE : Review the literature to update the MASCC guidelines from 2016 for controlling nausea and vomiting with systemic cancer treatment of low and minimal emetic potential. METHODS : A working group performed a ...
• Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant 

  Richardson, Simone I.; Kgagudi, Prudence; Manamela, Nelia P.; Kaldine, Haajira; Venter, Elizabeth M.; Pillay, Thanusha; Lambson, Bronwen E.; Van der Mescht, Mieke Adri; Hermanus, Tandile; Balla, Sashkia R.; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Du Pisanie, Marizane; Burgers, Wendy A.; Ntusi, Ntobeko A.B.; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa; Boswell, Michael T.; Moore, Penny L. (Cell Press, 2023-01)

  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4 and BA.5 variants caused major waves of infections. Here, we assess the sensitivity of BA.4 to binding, neutralization, and antibodydependent cellular ...

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