• T cell responses to SARS-CoV-2 spike cross-recognize Omicron 

  Keeton, Roanne; Tincho, Marius B.; Ngomti, Amkele; Baguma, Richard; Benede, Ntombi; Suzuki, Akiko; Khan, Khadija; Cele, Sandile; Bernstein, Mallory; Karim, Farina; Madzorera, Sharon V.; Moyo-Gwete, Thandeka; Mennen, Mathilda; Skelem, Sango; Adriaanse, Marguerite; Mutithu, Daniel; Aremu, Olukayode; Stek, Cari; Du Bruyn, Elsa; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Mendes, Adriano; Strydom, Amy; Venter, Marietjie; Giandhari, Jennifer; Naidoo, Yeshnee; Pillay, Sureshnee; Tegally, Houriiyah; Grifoni, Alba; Weiskopf, Daniela; Sette, Alessandro; Wilkinson, Robert J.; De Oliveira, Tulio; Bekker, Linda‑Gail; Gray, Glenda; Ueckermann, Veronica; Rossouw, Theresa; Boswell, M.T.; Bhiman, Jinal N.; Moore, Penny L.; Sigal, Alex; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Riou, Catherine (Nature Research, 2022-03-17)

  The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations1,2 that contribute to viral escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other ...
• Comparative molecular genetics of odontogenic keratocysts in sporadic and syndromic patients 

  Ambele, Melvin Anyasi; Robinson, Liam; Van Heerden, M.B. (Marlene); Pepper, Michael Sean; Van Heerden, Willem Francois Petrus (Elsevier, 2023-01)

  Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
• Immune and metabolic alterations in children with perinatal HIV exposure 

  Du Toit, Louise de Villiers; Prinsloo, Andrea; Steel, Helen C.; Feucht, Ute; Louw, Roan; Rossouw, Theresa (MDPI, 2023-02)

  With the global rollout of mother-to-child prevention programs for women living with HIV, vertical transmission has been all but eliminated in many countries. However, the number of children who are exposed in utero to HIV ...
• Phenylalanine metabolism and tetrahydrobiopterin bio-availability in COVID-19 and HIV 

  Mason, Shayne; Van Reenen, Mari; Rossouw, Theresa; Lindeque, Zander; Louw, Roan (Elsevier, 2023-03)

  Please read abstract in article.
• Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility 

  Gocz, Balazs; Rumpler, Eva; Sarvari, Miklos; Skrapits, Katalin; Takacs, Szabolcs; Farkas, Imre; Csillag, Veronika; Trinh, Sarolta H.; Bardoczi, Zsuzsanna; Solymosi, Norbert; Poliska, Szilard; Bartoloni, Lucia; Zouaghi, Yassine; Messina, Andrea; Pitteloud, Nelly; Anderson, Ross Calley; Millar, Robert P.; Quinton, Richard; Manchishi, Stephen M.; Colledge, William H.; Hrabovszky, Erik (National Academy of Sciences, 2022-06-28)

  Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms underlying this signaling, we thoroughly characterized ...
• Pro-inflammatory interactions of dolutegravir with human neutrophils in an in vitro study 

  Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, P.W.A. (Pieter Willem Adriaan); Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)

  There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
• Shared N417-dependent epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus variants 

  Moyo-Gwete, Thandeka; Madzivhandila, Mashudu; Mkhize, Nonhlanhla N.; Kgagudi, Prudence; Ayres, Frances; Lambson, Bronwen E.; Manamela, Nelia P.; Richardson, Simone, I.; Makhado, Zanele; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita Roma; Burgers, Wendy A.; Ntusi, Ntobeko A.B.; Rossouw, Theresa M.; Ueckermann, Veronica; Boswell, Michael T.; Moore, Penny L. (American Society for Microbiology, 2022-07)

  As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, several variants of concern (VOCs) have arisen which are defined by multiple mutations in their spike proteins. These VOCs have shown ...
• SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity 

  Richardson, Simone I.; Manamela, Nelia P.; Motsoeneng, Boitumelo M.; Kaldine, Haajira; Ayres, Frances; Makhado, Zanele; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Sullivan, Nancy J.; Misasi, John; Gray, Glenda G.; Bekker, Linda‑Gail; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Moore, Penny L. (Cell Press, 2022-02-15)

  Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing cytotoxic ...
• SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals 

  Richardson, Simone I.; Madzorera, Tatenda; Spencer, Holly; Manamela, Nelia P.; Van der Mescht, Mieke Adri; Lambson, Bronwen E.; Oosthuysen, Brent; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Mzindle, Nonkululeko; Motlou, Thopisang; Strydom, Amy; Mendes, Adriano; Tegally, Houriiyah; De Beer, Zelda; De Villiers, Talita Roma; Bodenstein, Annie; Van den Berg, Gretha; Venter, Marietjie; De Oliviera, Tulio; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Moore, Penny L. (Cell Press, 2022-03-24)

  The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses to other variants of concern (VOCs) remains unknown. We ...
• Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern 

  Kitchin, Dale; Richardson, Simone I.; Van der Mescht, Mieke Adri; Motlou, Thopisang; Mzindle, Nonkululeko; Moyo-Gwete, Thandeka; Makhado, Zanele; Ayres, Frances; Manamela, Nelia P.; Spencer, Holly; Lambson, Bronwen; Oosthuysen, Brent; Kaldine, Haajira; Du Pisanie, Marizane; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Gray, Glenda G.; Bekker, Linda-Gail; Boswell, Michael T.; Rossouw, Theresa M.; Ueckermann, Veronica; Moore, Penny L. (Cell Press, 2022-03-15)

  The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding ...
• Dysbiosis and immune dysregulation : distilling the evidence 

  Rossouw, Theresa M.; Makhalanyane, Thulani P. (Lippincott, Williams & Wilkins, 2022-11)

  No abstract available.
• Effect of a ward-based outreach team and adherence game on retention and viral load suppression 

  Ngcobo, Sanele; Olorunju, Steve; Nkwenika, Tshifhiwa; Rossouw, Theresa M. (AOSIS, 2022-12-07)

  BACKGROUND : Only 66% of South African people living with HIV (PLWH) are virologically suppressed. Therefore, it is important to develop strategies to improve outcomes. OBJECTIVES : Assess the effect of interventions on ...
• Sex disparities in COVID-19 severity and outcome : are men weaker or women stronger? 

  Pivonello, Rosario; Auriemma, Renata S.; Pivonello, Claudia; Isidori, Andrea M.; Corona, Giovanni; Colao, Annamaria; Millar, Robert P. (Karger, 2021-10)

  The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health issue which has profound effects on most aspects of societal well-being, ...
• Research ethics support during the COVID-19 epidemic : a collaborative effort by South African research ethics committees 

  Rossouw, Theresa M.; Wassenaar, Douglas; Kruger, Mariana; Blockman, Marc; Hunter, Alistair; Burgess, Theresa (Health Systems Trust, 2021-12-01)

  The COVID-2019 pandemic caused disruption of health services globally due to increased need for critical care facilities and collateral damage to routine healthcare services. Global and local research into disease pathogenesis ...
• Rescue of cell surface expression and signaling of mutant follicle-stimulating hormone receptors 

  Hanyroup, Sharika; Anderson, Ross Calley; Nataraja, Selvaraj; Yu, Henry N.; Millar, Robert P.; Newton, Claire L. (Oxford University Press, 2021-12)

  Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones are cell-permeant small molecules that engage ...
• The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application 

  Anderson, Richard A.; Millar, Robert P. (Wiley, 2022-05)

  The delivery of gonadotropin-releasing hormone (GnRH) in a pulsatile mode to the gonadotropes has long been known to be essential for normal reproductive function. There have been numerous studies aimed at dissecting out ...
• Slc7a8 deletion is protective against diet-induced obesity and attenuates lipid accumulation in multiple organs 

  Pitere, Reabetswe R.; Van Heerden, Marlene B.; Pepper, Michael Sean; Ambele, Melvin Anyasi (MDPI, 2022-02)

  Adipogenesis, through adipocyte hyperplasia and/or hypertrophy, leads to increased adiposity, giving rise to obesity. A genome-wide transcriptome analysis of in vitro adipogenesis in human adipose-derived stromal/stem ...
• Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus : putative underlying mechanistic cascade 

  Singh, Ankur; Lal, Bechan; Parkash, Jyoti; Millar, Robert P. (Elsevier, 2021-10)

  Unlike mammals, two kisspeptins genes encoding, kiss1 and kiss2 are detected in fishes with highly varied and contradictory difference in their reproductive activities. The present study was undertaken to examine the direct ...
• Spectrum of MYO7A mutations in an indigenous South African population further elucidates the nonsyndromic autosomal recessive phenotype of DFNB2 to include both homozygous and compound heterozygous mutations 

  Kabahuma, Rosemary Ida; Schubert, Wolf-Dieter; Labuschagne, Christiaan; Yan, Denise; Blanton, Susan Halloran; Pepper, Michael Sean; Liu, Xue Zhong (MDPI, 2021-02-15)

  MYO7A gene encodes unconventional myosin VIIA, which, when mutated, causes a phenotypic spectrum ranging from recessive hearing loss DFNB2 to deaf-blindness, Usher Type 1B (USH1B). MYO7A mutations are reported in nine DFNB2 ...
• Review manuscript targeting of the neutrophil as an adjunctive strategy in non-small cell lung cancer 

  Anderson, Ronald; Blidner, Ada Gabriela; Rapoport, Bernardo Leon (MDPI, 2021-06-08)

  Lung cancer remains the leading cause of cancer mortality in the United States, with non-small cell lung cancer (NSCLC) accounting for around 85% of cases. Of particular concern is the poor responsiveness of this malignancy ...

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