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Research Articles (Immunology)
(Nature Research, 2022-03-17)
The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations1,2
that contribute to viral escape from antibody neutralization3–6 and reduce vaccine
protection from infection7,8. The extent to which other ...
Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
With the global rollout of mother-to-child prevention programs for women living with HIV, vertical transmission has been all but eliminated in many countries. However, the number of children who are exposed in utero to HIV ...
Please read abstract in article.
(National Academy of Sciences, 2022-06-28)
Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian
estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms
underlying this signaling, we thoroughly characterized ...
There is increasing awareness of an association between the uptake of the HIV integrase inhibitor,
dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development
of the metabolic syndrome, ...
(American Society for Microbiology, 2022-07)
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, several variants of concern (VOCs) have arisen which are defined by multiple mutations in their spike proteins. These VOCs have shown ...
(Cell Press, 2022-02-15)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape
from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing
(Cell Press, 2022-03-24)
The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by vaccines or infection. However,
whether Omicron triggers cross-reactive humoral responses to other variants of concern (VOCs) remains unknown.
(Cell Press, 2022-03-15)
The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely
deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing
and binding ...
(Lippincott, Williams & Wilkins, 2022-11)
No abstract available.
BACKGROUND : Only 66% of South African people living with HIV (PLWH) are virologically
suppressed. Therefore, it is important to develop strategies to improve outcomes.
OBJECTIVES : Assess the effect of interventions on ...
The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health issue which has profound effects on most aspects of societal well-being, ...
(Health Systems Trust, 2021-12-01)
The COVID-2019 pandemic caused disruption of health services globally due to increased need for critical care facilities and collateral damage to routine healthcare services. Global and local research into disease pathogenesis ...
(Oxford University Press, 2021-12)
Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones are cell-permeant small molecules that engage ...
The delivery of gonadotropin-releasing hormone (GnRH) in a pulsatile mode to the gonadotropes has long been known to be essential for normal reproductive function. There have been numerous studies aimed at dissecting out ...
Adipogenesis, through adipocyte hyperplasia and/or hypertrophy, leads to increased
adiposity, giving rise to obesity. A genome-wide transcriptome analysis of in vitro adipogenesis in
human adipose-derived stromal/stem ...
Unlike mammals, two kisspeptins genes encoding, kiss1 and kiss2 are detected in fishes with highly varied and contradictory difference in their reproductive activities. The present study was undertaken to examine the direct ...
MYO7A gene encodes unconventional myosin VIIA, which, when mutated, causes a phenotypic spectrum ranging from recessive hearing loss DFNB2 to deaf-blindness, Usher Type 1B (USH1B). MYO7A mutations are reported in nine DFNB2 ...
Lung cancer remains the leading cause of cancer mortality in the United States, with non-small cell lung cancer (NSCLC) accounting for around 85% of cases. Of particular concern is the poor responsiveness of this malignancy ...