• Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model 

  Peta, Kimberly; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2023-10)

  The prevalence of breast cancer (BC) continues to increase and is the leading cause of cancer deaths in many countries. Numerous in vitro and in vivo studies have demonstrated that 2‐methoxyestradiol (2‐ME) has ...
• Role of Neurokinin B in gametogenesis and steroidogenesis of freshwater catfish, Clarias batrachus 

  Singh, Ankur; Lal, Bechan; Kumar, Pankaj; Parhar, Ishwar S.; Millar, Robert P. (Springer, 2023-08)

  Neurokinin B (NKB), a recently discovered neuropeptide, plays a crucial role in regulating the kiss-GnRH neurons in vertebrate's brain. NKB is also characterized in gonadal tissues; however, its role in gonads is poorly ...
• How nuclear envelope dynamics can direct laminopathy phenotypes 

  Van Heerden, David; Klima, Stefanie; Van den Bout, Iman (Elsevier, 2024-02)

  The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The ...
• Role of clock genes and circadian rhythm in renal cell carcinoma : recent evidence and therapeutic consequences 

  Santoni, Matteo; Molina-Cerrillo, Javier; Santoni, Giorgio; Lam, Elaine T.; Massari, Francesco; Mollica, Veronica; Mazzaschi, Giulia; Rapoport, Bernardo Leon; Grande, Enrique; Buti, Sebastiano (MDPI, 2023-01-07)

  Circadian rhythm regulates cellular differentiation and physiology and shapes the immune response. Altered expression of clock genes might lead to the onset of common malignant cancers, including Renal Cell Carcinoma ...
• 2023 updated MASCC/ESMO consensus recommendations: controlling nausea and vomiting with chemotherapy of low or minimal emetic potential 

  Olver, Ian; Clark-Snow, Rebecca; Ruhlmann, Christina H.; Garcia-del-Barrio, Maria-Angeles; Schwartzberg, Lee; Rapoport, Bernardo Leon; Jahn, Franziska (Springer, 2024-01)

  PURPOSE : Review the literature to update the MASCC guidelines from 2016 for controlling nausea and vomiting with systemic cancer treatment of low and minimal emetic potential. METHODS : A working group performed a ...
• Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant 

  Richardson, Simone I.; Kgagudi, Prudence; Manamela, Nelia P.; Kaldine, Haajira; Venter, Elizabeth M.; Pillay, Thanusha; Lambson, Bronwen E.; Van der Mescht, Mieke Adri; Hermanus, Tandile; Balla, Sashkia R.; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Du Pisanie, Marizane; Burgers, Wendy A.; Ntusi, Ntobeko A.B.; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa; Boswell, Michael T.; Moore, Penny L. (Cell Press, 2023-01)

  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4 and BA.5 variants caused major waves of infections. Here, we assess the sensitivity of BA.4 to binding, neutralization, and antibodydependent cellular ...
• Metabolic alterations in mothers living with HIV and their HIV-exposed, uninfected infants 

  Du Toit, Louise de Villiers; Mason, Shayne; Van Reenen, Mari; Rossouw, Theresa; Louw, Roan (MDPI, 2024-02)

  HIV-exposed, uninfected (HEU) children present with suboptimal growth and a greater susceptibility to infection in early life when compared to HIV-unexposed, uninfected (HUU) children. The reasons for these findings are ...
• Biomarkers for disease progression identified in psoriasis patients : a pilot study 

  Mkhize, Nomzamo; Kgokolo, Mahlatse C.M.; Steel, Helen C.; Meyer, Pieter W. A.; Kwofie, Luyanda Laura Illicia (Wiley, 2023-09)

  BACKGROUND : Psoriasis is an immune-mediated polygenic skin disorder. It is influenced by multiple genes as well as environmental factors including infection and trauma. Psoriasis is associated with molecular biomarkers ...
• Filgrastim biosimilar (EP2006) : a review of 15 years’ post-approval evidence 

  Gascón, Pere; Harbeck, Nadia; Rapoport, Bernardo Leon; Anderson, Ronald; Brueckmann, Ines; Howe, Sebastian; Aapro, Matti (Elsevier, 2024-04)

  Filgrastim is approved for several indications, including reduction of the incidence and duration of chemotherapy-induced neutropenia and for stem cell mobilization. The filgrastim biosimilar, EP2006, has been available ...
• Emerging markers of cancer cachexia and their relationship to sarcopenia 

  Lipshitz, Melanie; Visser, J.; Anderson, Ronald; Nel, D.G.; Smit, T.G. (Theunis); Steel, Helen C.; Rapoport, Bernardo Leon (Springer, 2023-12)

  PURPOSE : Emerging biomarkers of cancer cachexia and their roles in sarcopenia and prognosis are poorly understood. Baseline assessments of anthropometrics, sarcopenia, cachexia status and biomarkers of cachexia were ...
• Comparative evaluation of the cytotoxicity of doxorubicin in BT-20 triple-negative breast carcinoma monolayer and spheroid cultures 

  Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)

  Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
• Characteristics and outcomes of neonates with intrapartum asphyxia managed with therapeutic hypothermia in a public tertiary hospital in South Africa 

  Nakwa, Firdose Lambey; Sepeng, Letlhogonolo; Van Kwawegen, Alison; Thomas, Reenu; Seake, Karabo; Mogajane, Tshiamo; Ntuli, Nandi; Ondongo‑Ezhet, Claude; Kesting, Samantha; Kgwadi, Dikeledi Maureen; Kamanga, Noela Holo Bertha; Coetser, Annaleen; Van Rensburg, Jeanette; Pepper, Michael Sean; Velaphi, Sithembiso C. (BMC, 2023-01-31)

  BACKGROUND : In randomized clinical trials, therapeutic hypothermia (TH) has been shown to reduce death and/or moderate-to-severe disability in neonates with hypoxic ischemic encephalopathy (HIE) in high-income countries, while ...
• 2023 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting 

  Herrstedt, J.; Clark-Snow, R.; Ruhlmann, C.H.; Molassiotis, A.; Olver, I.; Rapoport, Bernardo Leon; Aapro, M.; Dennis, K.; Hesketh, P.J.; Navari, R.M.; Schwartzberg, L.; Affronti, M.L.; Garcia-Del-Barrio, M.A.; Chan, A.; Celio, L.; Chow, R.; Fleury, M.; Gralla, R.J.; Giusti, R.; Jahn, F.; Iihara, H.; Maranzano, E.; Radhakrishnan, Venkatraman; Saito, Mitsue; Sayegh, Paula; Bosnjak, S.; Zhang, L.; Lee, J.; Ostwal, V.; Smit, T.; Zilic, A.; Jordan, Karin; Scotté, F. (Elsevier, 2024-02)

  Nausea and vomiting are still considered to be two of the most troublesome adverse events (AEs) for patients treated with antineoplastic therapy. To optimise the utility of available antiemetic prophylaxis, updated reviews ...
• Glucocorticoids with or without fludrocortisone in septic shock : a narrative review from a biochemical and molecular perspective 

  Nethathe, Gladness D.; Lipman, Jeffrey; Anderson, Ronald; Fuller, Peter J.; Feldman, Charles (Elsevier, 2024-01)

  Two randomised controlled trials have reported a reduction in mortality when adjunctive hydrocortisone is administered in combination with fludrocortisone compared with placebo in septic shock. A third trial did not support ...
• Transforming growth factor-β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma 

  Kgokolo, C.M.; Malinga, Nonkululeko Z.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon (Elsevier, 2024-04)

  The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells ( n = 7) in a cohort of patients with ...
• Allergic rhinitis : review of the diagnosis and management : South African Allergic Rhinitis Working Group 

  Richards, Guy A.; Gray, Claudia L.; De Waal, Pieter; Friedman, Ray; Hockman, Maurice; Karabus, Sarah J.; Lodder, Cornelia M.; Mabelane, Tshegofatso; Mosito, Sylvia M.; Nanan, Ashen; Peter, Jonny G.; Quitter, Traugott H.C.; Van den Berg, Sylvia; Van Niekerk, Andre; Vardas, Eftyhia; Feldman, Charles (AOSIS, 2023-10-30)

  BACKGROUND : Allergic rhinitis (AR) has a significant impact on the community as a whole with regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis, treatment and review of ...
• COVID-19 severity and in-hospital mortality in an area with high HIV prevalence 

  Boswell, Michael; Maimela, T.C.R. (Tshegofatso); Hameiri-Bowen, Dan; Riley, George; Malan, Albertus; Steyn, Nickietta; Nolutshungu, Nomonde; De Villiers, Talita R.; De Beer, Zelda; Mathabathe, John; Tshabalala, Khanyisile; Abdullah, Fareed; Ramlall, Rajiev; Heystek, Marthinus J.; Basu, Debashis; Rheeder, Paul; Ueckermann, Veronica; Van Hougenhouck-Tulleken, W.G. (Wesley) (AOSIS, 2023-01-27)

  BACKGROUND : HIV infection causes immune dysregulation affecting T-cell and monocyte function, which may alter coronavirus disease 2019 (COVID-19) pathophysiology. OBJECTIVES : We investigated the associations among ...
• Considerations for enhanced mesenchymal stromal/stem cell myogenic commitment in vitro 

  Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean (Wiley, 2024-01)

  The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
• Emetic risk classification and evaluation of the emetogenicity of antineoplastic agents—updated MASCC/ESMO consensus recommendation 

  Jordan, Karin; Chan, Alexandre; Gralla, Richard J.; Jahn, Franziska; Rapoport, Bernardo Leon; Ruhlmann, Christina H.; Sayegh, Paula; Hesketh, Paul J. (Springer, 2024-01)

  PURPOSE : Our goal was to identify new anticancer agents approved by the US Food and Drug Administration (FDA) and the European Medical Agency (EMA) since the 2016 MASCC/ESMO antiemetic update and classify their emetic ...
• A prospective, real‑world, multinational study of febrile neutropenia (FN) occurrence in oncology patients receiving chemotherapy with intermediate risk of FN : a MASCC neutropenia, infection, and myelosuppression study group initiative 

  Rapoport, Bernardo Leon; Garcia‑Morillo, Marcial; Font, Carme; Samoon, Zarka; Jabbar, Adnan Abdul; Kourie, Hampig Raphael; Kayumba, Aline; Esposito, Francis; Popescu, Razvan Andrei; Garcia‑Gomez, Jesus; Heyman, Liezl; Smit, Teresa; Krendyukov, Andriy; Mathieson, Nicola; Cooksley, Tim; Anderson, Ronald; Klastersky, Jean (Springer, 2023-10-13)

  PURPOSE : Limited knowledge is available on the incidence of febrile neutropenia (FN) in intermediate-risk patients and the rationale for use of granulocyte colony-stimulating factor (G-CSF) in these patients. We aimed to ...

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