Mudd, Gemma; Hendrikse, Megan; Shave, Steven; Houston, Douglas R.; Millar, Robert P.; Auer, Manfred(Wiley, 2024-04)
The RFamide family of peptides represents an important class of GPCR ligand neuropeptides covering a wide range of biological functions. While many analogues of the highly conserved C-terminal RFamide motif within this ...
Rapoport, Bernardo Leon; Steel, Helen C.; Benn, Carol A.; Nayler, Simon; Smit, Teresa; Heyman, Liezl; Theron, Annette J.; Hlatshwayo, Nomsa; Kwofie, Luyanda Laura Illicia; Meyer, P.W.A. (Pieter Willem Adriaan); Anderson, Ronald(Frontiers Media, 2023-03-30)
Neoadjuvant chemotherapy (NAC) may alter the immune landscape of patients
with early breast cancer (BC), potentially setting the scene for more effective
implementation of checkpoint-targeted immunotherapy. This issue ...
Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized ...
Platelets are increasingly recognized for their role as mediators of immune response and inflammation. As major components of the hematological system, they form an important bridge between immunity and coagulation. When ...
Strydom, Adele; Van Rensburg, Jeanne; Pepper, Michael Sean(Frontiers Media, 2023-12-06)
With regard to the use and transfer of research participants’ personal information,
samples and other data nationally and internationally, it is necessary to construct a
data management plan. One of the key objectives ...
Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa(Frontiers Media, 2023-08-14)
INTRODUCTION : SARS-CoV-2 elicits a hyper-inflammatory response that
contributes to increased morbidity and mortality in patients with COVID-19. In
the case of HIV infection, despite effective anti-retroviral therapy, ...
Dysregulation of the bone marrow niche resulting from the direct and indirect
effects of HIV infection contributes to haematological abnormalities observed in
HIV patients. The bone marrow niche is a complex, multicellular ...
The kinetics of Fc-mediated functions following SARS-CoV-2 infection or
vaccination in people living with HIV (PLWH) are not known. We compared
SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in ...
Robert (Bob) Millar will retire in 2024, after a long and distinguished career in neuroendocrinology. Claire and I have been working with Bob for some years and took on the task of organising a Festschrift to celebrate his ...
Richards, G.A.; Theron, Annette J.; Van den Bout, Jan Iman; Anderson, Ronald; Feldman, Charles; Van Zyl Smit, Richard; Chang, Ju-Wei; Tintinger, Gregory(European Respiratory Society, 2023-05)
BACKGROUND : Electronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and
various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered
safer than ...
Despite innovative advances in anti-infective therapies and vaccine development technologies,
community-acquired pneumonia (CAP) remains the most persistent cause of infection-related
mortality globally. Confronting the ...
Aside from their key protective roles in hemostasis and innate immunity, platelets are now
recognized as having multifaceted, adverse roles in the pathogenesis, progression and outcome of
many types of human malignancy. ...
Peta, Kimberly; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi(Wiley, 2023-10)
The prevalence of breast cancer (BC) continues to increase and is the leading cause
of cancer deaths in many countries. Numerous in vitro and in vivo studies have
demonstrated that 2‐methoxyestradiol (2‐ME) has ...
Neurokinin B (NKB), a recently discovered neuropeptide, plays a crucial role in regulating the kiss-GnRH neurons in vertebrate's brain. NKB is also characterized in gonadal tissues; however, its role in gonads is poorly ...
Van Heerden, David; Klima, Stefanie; Van den Bout, Iman(Elsevier, 2024-02)
The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The ...
Circadian rhythm regulates cellular differentiation and physiology and shapes the immune
response. Altered expression of clock genes might lead to the onset of common malignant cancers,
including Renal Cell Carcinoma ...
PURPOSE : Review the literature to update the MASCC guidelines from 2016 for controlling nausea and vomiting with systemic cancer treatment of low and minimal emetic potential.
METHODS : A working group performed a ...
Richardson, Simone I.; Kgagudi, Prudence; Manamela, Nelia P.; Kaldine, Haajira; Venter, Elizabeth M.; Pillay, Thanusha; Lambson, Bronwen E.; Van der Mescht, Mieke Adri; Hermanus, Tandile; Balla, Sashkia R.; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Du Pisanie, Marizane; Burgers, Wendy A.; Ntusi, Ntobeko A.B.; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa; Boswell, Michael T.; Moore, Penny L.(Cell Press, 2023-01)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4 and BA.5 variants caused
major waves of infections. Here, we assess the sensitivity of BA.4 to binding, neutralization, and antibodydependent
cellular ...