• Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus : putative underlying mechanistic cascade 

  Singh, Ankur; Lal, Bechan; Parkash, Jyoti; Millar, Robert P. (Elsevier, 2021-10)

  Unlike mammals, two kisspeptins genes encoding, kiss1 and kiss2 are detected in fishes with highly varied and contradictory difference in their reproductive activities. The present study was undertaken to examine the direct ...
• Spectrum of MYO7A mutations in an indigenous South African population further elucidates the nonsyndromic autosomal recessive phenotype of DFNB2 to include both homozygous and compound heterozygous mutations 

  Kabahuma, Rosemary Ida; Schubert, Wolf-Dieter; Labuschagne, Christiaan; Yan, Denise; Blanton, Susan Halloran; Pepper, Michael Sean; Liu, Xue Zhong (MDPI, 2021-02-15)

  MYO7A gene encodes unconventional myosin VIIA, which, when mutated, causes a phenotypic spectrum ranging from recessive hearing loss DFNB2 to deaf-blindness, Usher Type 1B (USH1B). MYO7A mutations are reported in nine DFNB2 ...
• Review manuscript targeting of the neutrophil as an adjunctive strategy in non-small cell lung cancer 

  Anderson, Ronald; Blidner, Ada Gabriela; Rapoport, Bernardo Leon (MDPI, 2021-06-08)

  Lung cancer remains the leading cause of cancer mortality in the United States, with non-small cell lung cancer (NSCLC) accounting for around 85% of cases. Of particular concern is the poor responsiveness of this malignancy ...
• Pulmonary toxicities associated with the use of immune checkpoint inhibitors: an update from the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer 

  Rapoport, Bernardo Leon; Shannon, Vickie R.; Cooksley, Tim; Johnson, Douglas B.; Anderson, Lindsay; Blidner, Ada Gabriela; Tintinger, Gregory Ronald; Anderson, Ronald (Frontiers Media, 2021-10)

  The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, with agents such as nivolumab, pembrolizumab, and cemiplimab targeting programmed cell death protein-1 (PD-1) and durvalumab, ...
• The COVID-19 treatment landscape : a South African perspective on a race against time 

  Hendricks, Candice Laverne; Herd, Candice; Nel, Marcel; Tintinger, Gregory Ronald; Pepper, Michael Sean (Frontiers Media, 2021-02-19)

  The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which ...
• Interactions of HIV and antiretroviral therapy with neutrophils and platelets 

  Madzime, Morris; Rossouw, Theresa M.; Theron, Annette J.; Anderson, Ronald; Steel, Helen C. (MDPI, 2021-03-12)

  Neutrophils are important components of the innate immune system that mediate pathogen defense by multiple processes including phagocytosis, release of proteolytic enzymes, production of reactive oxygen species, and ...
• Editorial : The role of platelet activation in the pathophysiology of HIV, tuberculosis and pneumococcal disease 

  Rossouw, Theresa M.; Feldman, Charles (MDPI, 2021-07-30)

  Platelets, best known as essential effector cells in coagulation and hemostasis, are increasingly recognized as major inflammatory cells that play a role in the innate and adaptive arms of the immune system. The interaction ...
• Differential responsiveness of the platelet biomarkers, systemic CD40 ligand, CD62P, and platelet-derived growth factor-BB, to virally-suppressive antiretroviral therapy 

  Steel, Helen C.; Venter, W.D. Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Arulappan, Natasha; Rossouw, Theresa M. (MDPI, 2021-01-29)

  Systemic biomarkers of inflammation, including cytokines and chemokines, are potentially useful in the management of both HIV infection and non-AIDS-defining disorders. However, relatively little is known about the utility ...
• Role of the kdpDE regulatory operon of Mycobacterium tuberculosis in modulating bacterial growth in vitro 

  Cholo, Moloko C.; Matjokotja, Maborwa T.; Osman, Ayman Gassim Elamin; Anderson, Ronald (MDPI, 2021-07-29)

  Bacteria use K+-uptake transporters differentially for adaptation in varying growth conditions. In Mycobacterium tuberculosis, two K+-uptake systems, the Trk comprising the CeoB and CeoC proteins and the Kdp consisting of ...
• Supportive care in patients with cancer during the COVID-19 pandemic 

  Aapro, Matti; Lyman, G.H.; Bokemeyer, C.; Rapoport, Bernardo Leon; Mathieson, N.; Koptelova, N.; Cornes, P.; Anderson, Ronald; Gascon, P.; Kuderer, N.M. (Elsevier, 2021)

  Cancer care has been profoundly impacted by the global pandemic of severe acute respiratory syndrome coronavirus 2 disease (coronavirus disease 2019, COVID-19), resulting in unprecedented challenges. Supportive care is an ...
• Evaluation of three different laboratory methods to detect preformed human leukocyte antigen antibodies in a South African kidney transplant population 

  Kwofie, Luyanda Laura Illicia; Anderson, Ronald; Steel, Helen C.; Meyer, P.W.A. (Pieter Willem Adriaan) (Makerere University Medical School, 2021-06)

  BACKGROUND : Anti-human leukocyte antigen antibodies (anti-HLA) play a crucial role in graft. Detection of anti-HLA, both pre- and post-transplant is a crucial investigation in clinical organ transplantation. OBJECTIVES ...
• Why is it important to correctly classify and report SARS-CoV-2 infections and COVID-19 deaths? 

  Ngcobo, Sanele; Rossouw, Theresa M.; Madela-Mntla, Edith (Health and Medical Publishing Group, 2020-12)

  BACKGROUND : In a public health emergency such as the coronavirus disease 2019 (COVID-19) pandemic, mortality surveillance is crucial, as it guides the public health response and serves as a measure of its effectiveness. ...
• Precision global health : a roadmap for augmented action 

  Sheat, Danny J.; De Castaneda, Rafael Ruiz.; Bempong, Nefti-Eboni; Raviglione, Mario; Machalaba, Catherine; Pepper, Michael Sean; Vayena, Effy; Ray, Nicolas; Wernli, Didier; Escher, Gerard; Grey, Francois; Elger, Bernice S.; Kleineberg, Kaj-Kolja; Beran, David; Miranda, J. Jaime; Huffman, Mark D.; Hersch, Fred; Andayi, Fred; Thumbi, Samuel M.; D’Acremont, Valerie; Hartley, Mary-Anne; Zinsstag, Jakob; Larus, James; Martínez, María Rodríguez; Guerin, Philippe J.; Merson, Laura; Ngyuen, Vinh-Kim; Rühli, Frank; Geissbuhler, Antoine; Salathé, Marcel; Bolon, Isabelle; Boehme, Catharina; Berkley, Seth; Valleron, Alain-Jacques; Keiser, Olivia; Kaiser, Laurent; Eckerle, Isabella; Utzinger, Jurg; Flahault, Antoine (AME Publishing Company, 2020-03)

  With increased complexity in various global health challenges comes a need for increased precision and the adoption of more tailored health interventions. Building on precision public health, we propose precision global ...
• Is targeting dysregulation in apoptosis splice variants in Mycobacterium tuberculosis (MTB) host interactions and splicing factors resulting in immune evasion by MTB strategies a possibility? 

  Dlamini, Zodwa; Alaouna, Mohammed; Cholo, Moloko C.; Hull, Rodney (Elsevier, 2020-09)

  Mycobacterium tuberculosis (Mtb), is one of the foremost organisms causing mortality in humans, and has been for most of human history. When faced with an infection the human immune system is ordinarily very competent in ...
• Southern African HIV Clinicians Society guidelines for harm reduction 

  Scheibe, Andrew; Sibeko, Goodman; Shelly, Shaun; Rossouw, Theresa M.; Zishiri, Vincent; Venter, Willem D.F. (Health and Medical Publishing Group, 2020-12-17)

  We support public-health-focused interventions, as opposed to recovery-focused interventions. We support the decriminalisation of drug use as much as we oppose the criminalisation of sex work, mandatory HIV disclosure ...
• Rapid evolution of our understanding of the pathogenesis of COVID-19 – implications for therapy 

  Mustafa, Fatima; Giles, Rachel; Pepper, Michael Sean (Health and Medical Publishing Group, 2020-12)

  COVID-19 severity appears to lie in its propensity to cause a hyperinflammatory response, attributed to the cytokine release syndrome (CRS) or ‘cytokine storm’, although the exact role of the CRS remains to be fully ...
• The impact of obesity on the cellular and molecular pathophysiology of COVID-19 

  Dhanraj, Priyanka;; Pitere, R.; Pepper, Michael Sean (Health and Medical Publishing Group, 2021-03)

  Emerging evidence reveals a strong association between COVID-19 and obesity in terms of disease severity, need for hospitalisation and risk of mortality. In this review, we discuss cellular and molecular mechanisms ...
• Privacy rights of human research participants in South Africa must be taken seriously 

  Staunton, Ciara; Adams, Rachel; Botes, M.; Dove, Edward S.; Horn, Lyn; Labuschaigne, Melodie; Loots, Glaudina; Mahomed, Safia; Olckers, Antonel; Pepper, Michael Sean; Pope, Anne; Ramsay, Michele; Loideain, Nora Ni; De Vries, Jantina (Health and Medical Publishing Group, 2020-03)

  The Protection of Personal Information Act 4 of 2013 (POPIA) was enacted by the South African (SA) parliament in 2013 after a long process of public consultation. To allow all sectors of SA society sufficient time to prepare ...
• An analysis of retracted articles with authors or co-authors from the African region : possible implications for training and awareness raising 

  Rossouw, Theresa M.; Matsau, Liapeng; Van Zyl, Christa (Sage, 2020-12)

  Retraction of research articles is increasing but the reasons and characteristics of retractions involving authors from Africa have not been studied. Using records from the Retraction Watch database, we analyzed information ...
• Child health, infant formula funding and South African health professionals : eliminating conflict of interest 

  Van Niekerk, Andre; Khan, Naazneen; Lake, Lori; Kroon, Max; Goga, Ameena Ebrahim; Witten, Chantell; Swart, Rina; Saloojee, Haroon; Scott, Chris; Manyuha, Madome; Doherty, Tanya (Health and Medical Publishing Group, 2020-04)

  Lake et al. refer to the Allergy Society of South Africa (ALLSA) as an example of a professional body that may be fostering transgressions of regulation R991 (R991) of the Regulations Relating to Foodstuffs for Infants and ...

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