PURPOSE : Emerging biomarkers of cancer cachexia and their roles in sarcopenia and prognosis are poorly understood. Baseline assessments of anthropometrics, sarcopenia, cachexia status and biomarkers of cachexia were ...
Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman(MDPI, 2023-05-19)
Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical
drug testing platforms, as they circumvent limitations associated with traditional monolayer cell
cultures. However, many of these ...
BACKGROUND : In randomized clinical trials, therapeutic hypothermia (TH) has been shown to reduce death and/or
moderate-to-severe disability in neonates with hypoxic ischemic encephalopathy (HIE) in high-income countries,
while ...
Nausea and vomiting are still considered to be two of the most troublesome adverse events (AEs) for patients treated with antineoplastic therapy. To optimise the utility of available antiemetic prophylaxis, updated reviews ...
Two randomised controlled trials have reported a reduction in mortality when adjunctive hydrocortisone is administered in combination with fludrocortisone compared with placebo in septic shock. A third trial did not support ...
The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells ( n = 7) in a cohort of patients with ...
Richards, Guy A.; Gray, Claudia L.; De Waal, Pieter; Friedman, Ray; Hockman, Maurice; Karabus, Sarah J.; Lodder, Cornelia M.; Mabelane, Tshegofatso; Mosito, Sylvia M.; Nanan, Ashen; Peter, Jonny G.; Quitter, Traugott H.C.; Van den Berg, Sylvia; Van Niekerk, Andre; Vardas, Eftyhia; Feldman, Charles(AOSIS, 2023-10-30)
BACKGROUND : Allergic rhinitis (AR) has a significant impact on the community as a whole with
regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis,
treatment and review of ...
BACKGROUND : HIV infection causes immune dysregulation affecting T-cell and monocyte
function, which may alter coronavirus disease 2019 (COVID-19) pathophysiology.
OBJECTIVES : We investigated the associations among ...
Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean(Wiley, 2024-01)
The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
Jordan, Karin; Chan, Alexandre; Gralla, Richard J.; Jahn, Franziska; Rapoport, Bernardo Leon; Ruhlmann, Christina H.; Sayegh, Paula; Hesketh, Paul J.(Springer, 2024-01)
PURPOSE : Our goal was to identify new anticancer agents approved by the US Food and Drug Administration (FDA) and the European Medical Agency (EMA) since the 2016 MASCC/ESMO antiemetic update and classify their emetic ...
PURPOSE : Limited knowledge is available on the incidence of febrile neutropenia (FN) in intermediate-risk patients and the rationale for use of granulocyte colony-stimulating factor (G-CSF) in these patients. We aimed to ...
PURPOSE : This review is an update of the MASCC/ESMO 2015 recommendations for the prophylaxis of acute and delayed nausea and vomiting induced by multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea ...
The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations1,2
that contribute to viral escape from antibody neutralization3–6 and reduce vaccine
protection from infection7,8. The extent to which other ...
Ambele, Melvin Anyasi; Robinson, Liam; Van Heerden, M.B. (Marlene); Pepper, Michael Sean; Van Heerden, Willem Francois Petrus(Elsevier, 2023-01)
Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
Du Toit, Louise de Villiers; Prinsloo, Andrea; Steel, Helen C.; Feucht, Ute Dagmar; Louw, Roan; Rossouw, Theresa(MDPI, 2023-02)
With the global rollout of mother-to-child prevention programs for women living with HIV, vertical transmission has been all but eliminated in many countries. However, the number of children who are exposed in utero to HIV ...
Gocz, Balazs; Rumpler, Eva; Sarvari, Miklos; Skrapits, Katalin; Takacs, Szabolcs; Farkas, Imre; Csillag, Veronika; Trinh, Sarolta H.; Bardoczi, Zsuzsanna; Solymosi, Norbert; Poliska, Szilard; Bartoloni, Lucia; Zouaghi, Yassine; Messina, Andrea; Pitteloud, Nelly; Anderson, Ross Calley; Millar, Robert P.; Quinton, Richard; Manchishi, Stephen M.; Colledge, William H.; Hrabovszky, Erik(National Academy of Sciences, 2022-06-28)
Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian
estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms
underlying this signaling, we thoroughly characterized ...
Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory(MDPI, 2022-12-19)
There is increasing awareness of an association between the uptake of the HIV integrase inhibitor,
dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development
of the metabolic syndrome, ...
Obesity is a pandemic affecting both adults and children with an increasing annual prevalence. Adipogenesis, a process in which adipocyte precursors differentiate into mature adipocytes, is considered an important process ...
The present study was undertaken with the initial objective of investigating the effects of six primary anti-pseudomonal antibiotics, namely amikacin, cefepime, ciprofloxacin, meropenem, piperacillin and tazobactam, on the ...