Browsing Research Articles (Pharmacology) by UP Author "Outhoff, Kim"

Browsing Research Articles (Pharmacology) by UP Author "Outhoff, Kim"

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  • Acute non-specific low back pain in primary care 
    Outhoff, Kim (Medpharm, 2014)
    Acute non-specific low back pain, usually a result of muscle strains and ligament sprains from lifting, exercising or moving unexpectedly, is commonly encountered in primary care. At any given time, approximately one in ...
  • Agomelatine : a review for general practitioners 
    Outhoff, Kim (South African Academy of Family Practice/Primary Care, 2012)
    Agomelatine is a novel melatonergic antidepressant that restores disrupted biological rhythms, essentially by resetting the circadian clock. Two different, non-monoaminergic, and possibly synergistic pathways, appear to ...
  • Antidepressant-induced sexual dysfunction 
    Outhoff, Kim (OpenJournals, 2009-07)
    Depression and sexual dysfunction are both common in the general population. When they co-exist they have the potential to impact negatively on each other in a bidirectional manner. Medication used to treat depression may ...
  • The art of prescribing trastuzumab for HER2-positive breast cancer 
    Outhoff, Kim (OpenJournals Publishing, 2011-03)
    The human epidermal growth factor receptor 2 (HER2) is overexpressed in HER2-positive breast cancer. This confers characteristics associated with an overall poor prognosis, with early metastases to major visceral sites and ...
  • Bipolar disorder : an update 
    Outhoff, Kim (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2017)
    Bipolar disorder, characterised by alternating discrete episodes of (hypo)mania and depression, provides unique diagnostic and treatment challenges. Updated diagnostic (DSM-5) and current pharmacological treatment ...
  • Burning issues in acute heart failure management 
    Ker, James A.; Outhoff, Kim (Medpharm Publications, 2019-12)
    In general, heart failure is the end-stage manifestation of cardiovascular disease and is an important and increasing cause of morbidity worldwide. Acute heart failure, whether of new onset or an exacerbation of chronic ...
  • Burning issues in blood pressure control 
    Ker, James A.; Outhoff, Kim (OASIS, 2019-03)
    Globally more than 1 billion people have hypertension and it is predicted that because of ageing populations and increasing sedentary lifestyles, this figure will rise to about 1.5 billion by 2025. Elevated blood pressure ...
  • Burning issues in the prevention of heart failure 
    Ker, James A.; Outhoff, Kim (MedPharm Publications, 2020-08)
    Chronic heart failure is common, debilitating, and often the culmination of pervasive cardiovascular insults that systematically undermine the heart’s circulatory capacity and invoke counterproductive neuro-hormonal ...
  • Burning issues in the prevention of heart failure 
    Ker, James A.; Outhoff, Kim (AOSIS Open Journals, 2019-07)
    Chronic heart failure is common, debilitating, and often the culmination of pervasive cardiovascular insults that systematically undermine the heart’s circulatory capacity and invoke counterproductive neuro-hormonal ...
  • Cognitive enhancement : a brief overview 
    Outhoff, Kim (MedPharm Publications, 2016)
    Cognitive enhancement involves the non-medical use of illicit and/or prescription drugs, such as agents prescribed for attention deficit/hyperactive disorder (ADHD) and narcolepsy, usually in order to stay awake and to ...
  • COVID-19 and our crowning glory 
    Outhoff, Kim (Medpharm Publications, 2020-12-10)
    The inaugural issue of The South African General Practitioner (SAGP) is published in an unprecedented time of uncertainty, fear and a 21-day nationwide lockdown. The country is rallying to limit the spread of the spiky, ...
  • COVID-19 treatment : a growing (anti)body of evidence 
    Outhoff, Kim (Medpharm Publications, 2020-11)
    Our lives changed dramatically eight months ago when we went into a hard nationwide lockdown in a bid to limit the transmission of our new spiky foe, SARS-CoV-2. We endured the uncertainties of autumn, and then the winter ...
  • Depression in doctors : a bitter pill to swallow 
    Outhoff, Kim (Medpharm Publications, NISC (Pty) and Cogent, Taylor and Francis Group, 2019)
    At some point in their career, at least a third of doctors suffer personal health problems such as injury, aging, or physical and mental illness, which detract from their ability to function properly and to practice ...
  • Evidence of the safety and efficacy of statins 
    Outhoff, Kim (Medpharm Publications, 2016)
    Since their introduction in 1987, statins have become the largest-selling prescription drugs worldwide, and have kept both the scientific and lay press captivated. This year alone has seen reports that statins may prevent ...
  • Evidence that changes the way you practice bipolar disorder : mania and depression explained 
    Outhoff, Kim (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor & Francis Group, 2016-05)
    Bipolar Disorder (BD) is characterised by alternating discrete episodes of depression and mania. Rational pharmacotherapy necessitates an appreciation of these different phases and of the possible underlying pathophysiology. ...
  • Evidence-based treatment of acute otitis externa 
    Outhoff, Kim (Medpharm, 2014)
    Acute otitis externa (AOE), or diffuse inflammation of the external ear canal, causes a range of symptoms, including otalgia, otorrhoea, hearing loss and itching. Despite AOE being common, with a 12-month prevalence of ...
  • Grommets 
    Outhoff, Kim (MedPharm Publications, 2015)
    Children younger than 7 years are at increased risk of otitis media because of their immature immune systems and poorly functioning eustachian tubes that normally ventilate the middle ear space and equalize pressure with ...
  • Grommets - an update on common indications for tympanostomy tube placement 
    Outhoff, Kim (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2017)
    Children younger than 7 years are at increased risk of otitis media because of their immature immune systems and poorly functioning eustachian tubes that normally ventilate the middle ear space and equalize pressure with ...
  • Human epidermal growth factor receptor 2-positive breast cancer : which cytotoxic agent best complements trastuzumab's efficacy in vitro? 
    Hurrell, Tracey; Outhoff, Kim (Dove Medical Press, 2013-06-15)
    INTRODUCTION: Despite trastuzumab having enhanced selectivity for human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer cells, treatment is hampered by interindividual variation and tumors with high ...
  • Hypertension in goldminers 
    Maepe, L.M.; Outhoff, Kim (Health and Medical Publishing Group, 2012-01)
    BACKGROUND: Reliable information about the prevalence of hypertension, which is a major contributor to cardiovascular disease in general and to coronary heart disease in particular, in different geographical regions is ...