dc.contributor.author |
Valley Omar, Ziyaad
|
|
dc.contributor.author |
Tempia, Stefano
|
|
dc.contributor.author |
Hellferscee, Orienka
|
|
dc.contributor.author |
Walaza, sibongile
|
|
dc.contributor.author |
Variava, Ebrahim
|
|
dc.contributor.author |
Dawood, Halima
|
|
dc.contributor.author |
Kahn, Kathleen
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|
dc.contributor.author |
Meredith, McMorrow
|
|
dc.contributor.author |
Pretorius, Marthi
|
|
dc.contributor.author |
Mtshali, Senzo
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|
dc.contributor.author |
Mamorobela, Ernest
|
|
dc.contributor.author |
Wolter, Nicole
|
|
dc.contributor.author |
Venter, Marietjie
|
|
dc.contributor.author |
Von Gottenberg, Anne
|
|
dc.contributor.author |
Cohen, Cheryl
|
|
dc.contributor.author |
Treurnicht, Florette K.
|
|
dc.date.accessioned |
2022-11-24T08:23:25Z |
|
dc.date.available |
2022-11-24T08:23:25Z |
|
dc.date.issued |
2022-03 |
|
dc.description.abstract |
BACKGROUND: We aimed to describe the prevalence of human respiratory syncytial virus (HRSV) and evaluate associations between HRSV subgroups and/or genotypes and epidemiologic characteristics and clinical outcomes in patients hospitalized with severe respiratory illness (SRI).
METHODS: Between January 2012 and December 2015, we enrolled patients of all ages admitted to two South African hospitals with SRI in prospective hospital-based syndromic surveillance. We collected respiratory specimens and clinical and epidemiological data. Unconditional random effect multivariable logistic regression was used to assess factors associated with HRSV infection.
RESULTS: HRSV was detected in 11.2% (772/6908) of enrolled patients of which 47.0% (363/772) were under the age of 6 months. There were no differences in clinical outcomes of HRSV subgroup A-infected patients compared with HRSV subgroup B-infected patients but among patients aged <5 years, children with HRSV subgroup A were more likely be coinfected with Streptococcus pneumoniae (23/208, 11.0% vs. 2/90, 2.0%; adjusted odds ratio 5.7). No significant associations of HRSV A genotypes NA1 and ON1 with specific clinical outcomes were observed.
CONCLUSION: While HRSV subgroup and genotype dominance shifted between seasons, we showed similar genotype diversity as noted worldwide. We found no association between clinical outcomes and HRSV subgroups or genotypes. |
en_US |
dc.description.department |
Medical Virology |
en_US |
dc.description.sponsorship |
Centers for Disease Control and Prevention, |
en_US |
dc.description.uri |
https://onlinelibrary.wiley.com/journal/17502659 |
en_US |
dc.identifier.citation |
Valley-Omar Z., Tempia S., Hellferscee O., et al. Human respiratory syncytial virus diversity and epidemiology among patients hospitalized with severe respiratory illness in South Africa, 2012-2015. Influenza and other Respiratory Viruses 2022;16(2):222-235. doi:10.1111/irv.12905. |
en_US |
dc.identifier.issn |
1750-2659 (online) |
|
dc.identifier.issn |
1750-2640 (print) |
|
dc.identifier.other |
10.1111/irv.12905 |
|
dc.identifier.uri |
https://repository.up.ac.za/handle/2263/88474 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.rights |
© 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License. |
en_US |
dc.subject |
Genotype |
en_US |
dc.subject |
Genetics |
en_US |
dc.subject |
South Africa (SA) |
en_US |
dc.subject |
Human respiratory syncytial virus (HRSV) |
en_US |
dc.subject |
Severe respiratory illness (SRI) |
en_US |
dc.title |
Human respiratory syncytial virus diversity and epidemiology among patients hospitalized with severe respiratory illness in South Africa, 2012-2015 |
en_US |
dc.type |
Article |
en_US |