Medical Virology

Medical Virology

 

The mission of the Department of Medical Virology is to conduct medical research and provide diagnostic services in virology and to train technologists, pathologists and medical scientists who will be able to make a significant contribution in the field of virology in South Africa.

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  • Oymans, Judith; Wichgers Schreur, Paul J.; Van Oort, Sophie; Vloet, Rianka; Venter, Marietjie; Pijlman, Gorben P.; Van Oers, Monique M.; Kortekaas, Jeroen (MDPI, 2020-04)
    The genus Orthobunyavirus (family Peribunyaviridae, order Bunyavirales) comprises over 170 named mosquito- and midge-borne viruses, several of which cause severe disease in animals or humans. Their three-segmented genomes ...
  • Strehlau, Renate; Paximadis, Maria; Patel, Faeezah; Burke, Megan; Technau, Karl-Gunter; Shiau, Stephanie; Abrams, Elaine J.; Sherman, Gayle G.; Hunt, Gillian; Ledwaba, Johanna; Mazanderani, Ahmad Haeri; Tiemessen, Caroline T.; Kuhn, Louise (Wolters Kluwer Health, 2019-09)
    BACKGROUND : Prompt initiation of antiretroviral therapy (ART) for HIV-infected infants is strongly recommended but diagnostic confirmation is important as committing children to life-long ART carries serious health and ...
  • Netshikweta, Rembuluwani; Chidamba, Lizyben; Nadan, Sandrama; Taylor, Maureen B.; Page, N.A. (Nicola) (Wiley, 2020)
    Human bocavirus (HBoV) is known to be associated with a variety of clinical manifestation including acute gastroenteritis (AGE). Despite their global prevalence, no data is available on the epidemiology of HBoV associated ...
  • Mazanderani, Ahmad Haeri; Murray, Tanya Y.; Sherman, Gayle G.; Snyman, Tracy; George, Jaya; Avenant, T.J. (Theunis Johannes); Goga, Ameena Ebrahim; Pepper, Michael Sean; Du Plessis, Nicolette M. (Wiley Open Access, 2019-06)
    INTRODUCTION : To date, very little programmatic data has been published regarding serial antiretroviral (ARV) levels in infants exposed to maternal treatment and/or infant prophylaxis during the first months of life. Such ...
  • Hamiwe, Thabo; Kock, Marleen M.; Magwira, C.A. (Cliff); Antiabong, John Francis; Ehlers, M.M. (Marthie Magdaleen) (Elsevier, 2019-02)
    The development of antibiotic resistance and dissemination of its determinants is an emerging public health problem as it compromises treatment options of infections that were, until recently, treatable. Investigation of ...
  • Kremer, Wieke W.; Van Zummeren, Marjolein; Breytenbach, Erika; Richter, Karin Louise; Steenbergen, Renske D.M.; Meijer, Chris J.L.M.; Dreyer, Greta (Wolters Kluwer Health, 2019-11)
    OBJECTIVE : To determine the performance of molecular screening strategies for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) in comparison with cytology screening in women living with HIV. DESIGN ...
  • Rwamwejo, Janvier; Ramos, Silvina; Morgan, Karen; Richter, Karin Louise; Kim, Chan Joo; Peris, Merce; Smith, Jennifer S. (BMJ Publishing Group, 2019-02)
    OBJECTIVE : Strong persuasive messaging by providers is a key predictor for patient acceptance of prophylactic human papillomavirus vaccination. We aimed to determine optimal messaging to promote human papillomavirus ...
  • Steyn, Jumari; Botha, Elizabeth; Stivaktas, Voul; Buss, Peter; Beechler, Brianna R.; Myburgh, Jan G.; Steyl, Johan Christian Abraham; Williams, J.H. (June Heather); Venter, Marietjie (Centers for Disease Control and Prevention, 2019-12)
    West Nile virus (WNV) lineage 2 is associated with neurologic disease in horses and humans in South Africa. Surveillance in wildlife and nonequine domestic species during 2010–2018 identified WNV in 11 (1.8%) of 608 animals ...
  • Steyn, Jumari; Botha, Elizabeth; Lourens, Carina W.; Coetzer, Jacobus A.W.; Venter, Marietjie (Centers for Disease Control and Prevention, 2019-12)
    Bagaza virus (BAGV) has not been reported in birds in South Africa since 1978. We used phylogenetic analysis and electron microscopy to identify BAGV as the likely etiology in neurologic disease and death in Himalayan monal ...
  • Bravo-Barriga, Daniel; Almeida, António P.G.; Parreira, Ricardo; Jimenez-Vidal, Daniel; Perez-Martin, Juan Enrique; Martín-Cuervo, María; Frontera, Eva (Elsevier Espana, 2019)
    La rápida expansión de Aedes (Stegomyia) albopictus (Skuse,1894) en Espa˜na desde su detección por primera vez en Catalu˜naen 20041ha demostrado su alta capacidad de dispersión y adapta-ción a diferentes ecosistemas. Esta ...
  • Mazanderani, Ahmad Haeri; Sherman, Gayle G. (F1000 Faculty Rev, 2019)
    Early diagnosis of HIV infection among infants and children is critical as prompt initiation of antiretroviral therapy prevents morbidity and death. Yet despite advances in the accuracy and availability of infant HIV ...
  • Gorsich, Erin E.; Beechler, Brianna R.; Van Bodegom, Peter M.; Govender, Danny; Guarido, Milehna M.; Venter, Marietjie; Schrama, Maarten (BioMed Central, 2019-10-02)
    BACKGROUND : Assessing adult mosquito populations is an important component of disease surveillance programs and ecosystem health assessments. Inference from adult trapping datasets involves comparing populations across space ...
  • Cohen, Cheryl; Tshangela, Akhona; Valley-Omar, Ziyaad; Iyengar, Preetha; Von Mollendorf, Claire; Walaza, Sibongile; Hellferscee, Orienka; Venter, Marietjie; Martinson, Neil; Mahlase, Gethwana; McMorrow, Meredith L.; Cowling, Benjamin J.; Treurnicht, Florette K.; Cohen, Adam L.; Tempia, Stefano (Oxford University Press, 2019-05)
    BACKGROUND : We estimated the household secondary infection risk (SIR) and serial interval (SI) for influenza transmission from HIV-infected and HIV-uninfected index cases. METHODS : Index cases were the first symptomatic ...
  • Markotter, Wanda; Geldenhuys, Marike; Jansen van Vuren, Petrus; Kemp, Alan; Mortlock, Marinda; Mudakikwa, Antoine; Nel, Louis Hendrik; Nziza, Julius; Paweska, Janusz Tadeusz; Weyer, Jacqueline (MDPI Publishing, 2019-07-02)
    A high diversity of corona- and paramyxoviruses have been detected in different bat species at study sites worldwide, including Africa, however no biosurveillance studies from Rwanda have been reported. In this study, ...
  • Bose, Michael E.; Shrivastava, Susmita; He, Jie; Nelson, Martha I.; Bera, Jayati; Fedorova, Nadia; Halpin, Rebecca; Town, Christopher D.; Lorenzi, Hernan A.; Amedeo, Paolo; Gupta, Neha; Noyola, Daniel E.; Videla, Cristina; Kok, Tuckweng; Buys, Amelia; Venter, Marietjie; Vabret, Astrid; Cordey, Samuel; Henrickson, Kelly J. (Public Library of Science, 2019-07-18)
    Human Parainfluenza viruses (HPIV) type 1 and 3 are important causes of respiratory tract infections in young children globally. HPIV infections do not confer complete protective immunity so reinfections occur throughout ...
  • Botha, Jean; Conradie, Francesca; Etheredge, Harriet; Fabian, June; Duncan, Mary; Mazanderani, Ahmad Haeri; Paximadis, Maria; Maher, Heather; Russell Britz; Loveland, Jerome; Strobele, Bernd; Rambarran, Sharan; Mahomed, Adam; Terblanche, Alta; Beretta, Marisa; Brannigan, Liam; Pienaar, Michael; Archibald-Durham, Lindsay; Lang, Allison; Tiemessen, Caroline T. (Lippincott Williams and Wilkins, 2018)
    OBJECTIVE : Transplant a liver from an HIV-positive mother to her HIV-negative child to save the child’s life. DESIGN : A unique case of living donor liver transplantation from an HIV-positive mother to her HIV-negative ...
  • Paweska, Janusz Tadeusz; Jansen van Vuren, Petrus; Kemp, Alan; Storm, Nadia; Grobbelaar, Antoinette A.; Wiley, Michael R.; Palacios, Gustavo; Markotter, Wanda (Centers for Disease Control and Prevention, 2018)
    We detected a high seroprevalence of Marburg virus (MARV) antibodies in fruit bats in South Africa; 19.1% of recaptured bats seroconverted. The MARV RNA isolated closely resembled the 1975 Ozolin strain. These findings ...
  • Dearden, C.X.; Jeevarathnum, A.C.; Havinga, J.; Green, Robin J. (Health and Medical Publishing Group, 2018)
    BACKGROUND : Respiratory syncytial virus (RSV) bronchiolitis is a seasonal disease that has an enormous burden on health systems across the world. RSV disease manifestations in children range from mild upper respiratory ...
  • Schmidt, Hanno; Hanemaaijer, Mark J.; Cornel, Anthony J.; Lanzaro, Gregory C.; Braack, L.E.O.; Lee, Yoosook (Taylor and Francis Open, 2018-10-03)
    The Aedes aegypti mitogenome (Mt) sequences of field isolates from California and South Africa revealed a deletion between position 14,522 and 14,659 of the Mt contig of the AaegL5 reference genome. The length of the ...
  • Van Zyl, Walda B.; Zhou, Nicolette A.; Wolfaardt, Marianne; Matsapola, Peter N.; Ngwana, Fhatuwani B.; Symonds, Erin M.; Fagnant-Sperati, Christine S.; Shirai, Jeffry H.; Kossik, Alexandra L.; Beck, Nicola K.; Komen, Evans; Mwangi, Benlick; Nyangao, James; Boyle, David S.; Borus, Peter; Taylor, Maureen B.; Meschke, J. Scott (IWA Publishing, 2019-09)
    Enteric virus environmental surveillance via a highly sensitive method is critical, as many enteric viruses have low infectious doses and can persist in the environment for extended periods. This study determined the ...

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