Medical Virology

Medical Virology

 

The mission of the Department of Medical Virology is to conduct medical research and provide diagnostic services in virology and to train technologists, pathologists and medical scientists who will be able to make a significant contribution in the field of virology in South Africa.

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Recent Submissions

  • Van Zummeren, Marjolein; Kremer, Wieke W.; Van Aardt, M.C. (Matthys Cornelis); Breytenbach, Erika; Richter, Karin Louise; Rozendaal, Lawrence; Witte, Birgit I.; De Strooper, Lise M.A.; Hesselink, Albertus T.; Heideman, Danielle A.M.; Snijders, Peter J.F.; Steenbergen, Renske D.M.; Dreyer, Greta; Meijer, Chris J.L.M. (Lippincott Williams and Wilkins, 2017-09)
    OBJECTIVE : Cervical cancer is the leading cause of cancer-related death in women in South Africa. This study evaluates DNA methylation levels in cervical (pre)cancer and aims to assess the value of high-risk human ...
  • Page, Nicola; Seheri, L.M.; Groome, M.J.; Moyes, J.; Walaza, S.; Mphahlele, J.; Kahn, K.; Kapongo, C.N.; Zar, H.J.; Tempia, S.; Cohen, C.; Madhi, S.A. (Elsevier, 2017)
    BACKGROUND : Rotavirus vaccination has reduced diarrhoeal morbidity and mortality globally. The monovalent rotavirus vaccine was introduced into the public immunization program in South Africa (SA) in 2009 and led to ...
  • Agha, Sheila B.; Chepkorir, Edith; Mulwa, Francis; Tigoi, Caroline; Arum, Samwel; Guarido, Milehna M.; Ambala, Peris; Chelangat, Betty; Lutomiah, Joel; Tchouassi, David P.; Turell, Michael J.; Sang, Rosemary (Public Library of Science, 2017-08-18)
    BACKGROUND : In April, 2004, chikungunya virus (CHIKV) re-emerged in Kenya and eventually spread to the islands in the Indian Ocean basin, South-East Asia, and the Americas. The virus, which is often associated with ...
  • Technau, Karl-Gunter; Mazanderani, Ahmad Haeri; Kuhn, Louise; Hans, Lucia; Strehlau, Renate; Abrams, Elaine J.; Conradie, Martie; Coovadia, Ashraf; Mbete, Ndileka; Murnane, Pamela M.; Patel, Faeezah; Shiau, Stephanie; Tiemessen, Caroline T.; Sherman, Gayle G. (BioMed Central, 2017-08-29)
    IINTRODUCTION : HIV-1 polymerase chain reaction (PCR) testing at birth aims to facilitate earlier initiation of antiretroviral therapy (ART) for HIV-infected neonates. Data from two years of universal birth testing ...
  • Sherman, Gayle G.; Mazanderani, Ahmad Haeri; Barron, Peter; Bhardwaj, Sanjana; Niit, Ronelle; Okobi, Margaret; Puren, Adrian; Jackson, Debra J.; Goga, Ameena Ebrahim (Edinburgh University Global Health Society, 2017-06)
    BACKGROUND : South Africa has utilized three independent data sources to measure the impact of its program for the prevention of mother–to–child transmission (PMTCT) of HIV. These include the South African National ...
  • Groome, Michelle J.; Koen, Anthonet; Fix, Alan; Page, Nicola; Jose, Lisa; Madhi, Shabir A.; McNeal, Monica; Dally, Len; Cho, Iksung; Power, Maureen; Flores, Jorge; Cryz, Stanley (Elsevier, 2017-08)
    BACKGROUND Efficacy of live oral rotavirus vaccines is reduced in low-income compared with high-income settings. Parenteral non-replicating rotavirus vaccines might offer benefits over oral vaccines. We assessed the ...
  • Chan, Martin C.W.; Hu, Yunwen; Chen, Haili; Podkolzin, Alexander T.; Zaytseva, Ekaterina V.; Komano, Jun; Sakon, Naomi; Poovorawan, Yong; Vongpunsawad, Sompong; Thanusuwannasak, Thanundorn; Hewitt, Joanne; Croucher, Dawn; Collins, Nikail; Vinje, Jan; Pang, Xiaoli L.; Lee, Bonita E.; De Graaf, Miranda; Van Beek, Janko; Vennema, Harry; Koopmans, Marion P.G.; Niendorf, Sandra; Poljsak-Prijatelj, Mateja; Steyer, Andrej; White, Peter A.; Lun, Jennifer H.; Mans, Janet; Hung, Tin-Nok; Kwok, Kirsty; Cheung, Kelton; Lee, Nelson; Chan, Paul K.S. (Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 2017-08)
    Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype since the initial emergence in China in late 2014. Global ...
  • Mazanderani, Ahmad Haeri; Moyo, Faith; Sherman, Gayle G. (Public Library of Science, 2017-05-11)
    BACKGROUND : Samples submitted for HIV PCR testing that fail to yield a positive or negative result represent missed diagnostic opportunities. We describe HIV PCR test rejections and indeterminate results, and the associated ...
  • Seleka, Mpho; Treurnicht, Florette K.; Tempia, Stefano; Hellferscee, Orienka; Mtshali, Senzo; Cohen, Adam L.; Buys, Amelia; McAnerney, Johanna M.; Besselaar, Terry G.; Pretorius, Marthi; Von Gottberg, Anne; Walaza, Sibongile; Cohen, Cheryl; Madhi, Shabir A.; Venter, Marietjie (Public Library of Science, 2017-05-25)
    BACKGROUND : Studies describing the epidemiology of influenza B lineages in South Africa are lacking. METHODS : We conducted a prospective study to describe the circulation of influenza B/Victoria and B/ Yamagata lineages ...
  • Tempia, Stefano; Walaza, Sibongile; Moyes, Jocelyn; Cohen, Adam L.; Von Mollendorf, Claire; McMorrow, Meredith L.; Treurnicht, Florette K.; Venter, Marietjie; Pretorius, Marthi A.; Hellferscee, Orienka; Wolter, Nicole; Von Gottberg, Anne; Nguweneza, Athermon; McAnerney, Johanna M.; Dawood, Halima; Variava, Ebrahim; Madhi, Shabir A.; Cohen, Cheryl (Centers for Disease Control and Prevention, 2017-07)
    The attributable fraction (AF) of influenza virus detection to illness has not been described for patients in different age groups or with different HIV infection statuses. We compared the age group–specific prevalence of ...
  • Page, Nicola; Groome, M.J.; Nadan, Sandrama; Netshikweta, Rembuluwani; Keddy, K.H.; Poonsamy, B.; Moyes, J.; Walaza, S.; Kahn, K.; Madhi, S.A.; Taylor, Maureen B.; Mans, Janet; Cohen, C. (Cambridge University Press , 2017-07)
    Public health interest in norovirus (NoV) has increased in recent years following improved diagnostics, global burden estimates and the development of NoV vaccine candidates. This study aimed to describe the detection rate, ...
  • Rossouw, Theresa M.; Van Rooyen, Marietjie; Richter, Karin Louise (Journal of Infection in Developing Countries, 2017)
    INTRODUCTION : Occupational injuries in medical students are concerning, especially in countries with a high prevalence of bloodborne infections. With more HIV-infected patients on antiretroviral treatment, appropriate ...
  • Mzingwane, Mayibongwe L.; Tiemessen, Caroline T. (Wiley, 2017-03)
    The establishment and maintenance of HIV reservoirs that lead to persistent viremia in patients on antiretroviral drugs remains the greatest challenge of the highly active antiretroviral therapy era. Cellular reservoirs ...
  • Cohen, Cheryl; Moyes, Jocelyn; Tempia, Stefano; Groome, Michelle; Walaza, Sibongile; Pretorius, Marthi A.; Naby, Fathima; Mekgoe, Omphile; Kahn, Kathleen; Von Gottberg, Anne; Wolter, Nicole; Cohen, Adam L.; Von Mollendorf, Claire; Venter, Marietjie; Madhi, Shabir A. (American Academy of Pediatrics, 2016-04)
    BACKGROUND : Increased morbidity and mortality from lower respiratory tract infection (LRTI) abstract has been suggested in HIV-exposed uninfected (HEU) children; however, the contribution of respiratory viruses is ...
  • Mazur, Natalie I.; Bont, Louis; Cohen, Adam L.; Cohen, Cheryl; Von Gottberg, Anne; Groome, Michelle J.; Hellferscee, Orienka; Klipstein-Grobusch, Kerstin; Mekgoe, Omphile Tschegofatso; Naby, Fathima; Moyes, Jocelyn; Tempia, Stefano; Treurnicht, Florette K.; Venter, Marietjie; Walaza, Sibongile; Wolter, Nicole; Madhi, Shabir A. (Oxford University Press, 2017-02)
    BACKGROUND : Molecular diagnostics enable sensitive detection of respiratory viruses, but their clinical significance remains unclear in pediatric lower respiratory tract infection (LRTI). We aimed to determine whether ...
  • Dietrich, Muriel; Kearney, Teresa; Seamark, Ernest; Markotter, Wanda (Oxford University Press, 2017-01)
    Animal-associated microbiotas form complex communities, which play crucial functions for their host, including susceptibility to infections. Despite increasing attention to bats as reservoirs of zoonotic pathogens, their ...
  • Millman, Alexander J.; Greenbaum, Adena; Walaza, Sibongile; Cohen, Adam L.; Groome, Michelle J.; Reed, Carrie; McMorrow, Meredith; Tempia, Stefano; Venter, Marietjie; Treurnicht, Florette K.; Madhi, Shabir A.; Cohen, Cheryl; Variava, Ebrahim (BioMed Central, 2017-02-02)
    BACKGROUND : Acute lower respiratory tract infections (LRTI) are a frequent cause of hospitalization and mortality in South Africa; however, existing respiratory severity scores may underestimate mortality risk in ...
  • Kiulia, Nicholas M.; Mans, Janet; Mwenda, J.M.; Taylor, Maureen B. (Springer, 2014-12)
    In this study, the prevalence and genotypes of noroviruses (NoVs) in selected water sources from rural, urban and refugee settings in Kenya were investigated. Ten litres each of river, household and borehole water ...
  • Mixao, Verónica; Barriga, Daniel Bravo; Parreira, Ricardo; Novo, Maria Teresa; Sousa, Carla Alexandra; Frontera, Eva; Venter, Marietjie; Braack, L.E.O.; Almeida, António P.G. (BioMed Central, 2016-11-25)
    BACKGROUND : Culex univittatus and Culex perexiguus mosquitoes (Diptera: Culicidae) are competent arbovirus vectors, but with unclear morphological differentiation. In Europe, and in the Iberian Peninsula in particular, ...
  • Mzingwane, Mayibongwe L.; Tiemessen, C.T.; Richter, Karin Louise; Mayaphi, Simnikiwe H.; Hunt, G.; Bowyer, S.M. (BioMed Central, 2016-10-12)
    BACKGROUND : Although the use of highly active antiretroviral therapy in HIV positive individuals has proved to be effective in suppressing the virus to below detection limits of commonly used assays, virological failure ...

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