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dc.contributor.author | Nyawo, Thembeka A.![]() |
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dc.contributor.author | Pheiffer, Carmen![]() |
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dc.contributor.author | Mazibuko-Mbeje, Sithandiwe E.![]() |
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dc.contributor.author | Mthembu, Sinenhlanhla X.H.![]() |
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dc.contributor.author | Nyambuya, Tawanda M.![]() |
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dc.contributor.author | Nkambule, Bongani B.![]() |
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dc.contributor.author | Sadie-Van Gijsen, Hanel![]() |
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dc.contributor.author | Strijdom, Hans![]() |
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dc.contributor.author | Tiano, Luca![]() |
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dc.contributor.author | Dludla, Phiwayinkosi V.![]() |
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dc.date.accessioned | 2022-06-28T04:40:21Z | |
dc.date.available | 2022-06-28T04:40:21Z | |
dc.date.issued | 2021-11-04 | |
dc.description.abstract | Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease. | en_US |
dc.description.department | Obstetrics and Gynaecology | en_US |
dc.description.librarian | am2022 | en_US |
dc.description.sponsorship | The Biomedical Research and Innovation Platform of the South African Medical Research Council (SAMRC); the National Research Foundation; the DST-NRF Professional Development Programme (PDP) and the SAMRC through its Division of Research Capacity Development under the internship scholarship program from funding received from the South African National Treasury. | en_US |
dc.description.uri | https://www.mdpi.com/journal/antioxidants | en_US |
dc.identifier.citation | Nyawo, T.A.; Pheiffer, C.; Mazibuko-Mbeje, S.E.; Mthembu, S.X.H.; Nyambuya, T.M.; Nkambule, B.B.; Sadie-Van Gijsen, H.; Strijdom, H.; Tiano, L.; Dludla, P.V. Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets. Antioxidants 2021, 10, 1758. https://DOI.org/10.3390/antiox10111758. | en_US |
dc.identifier.issn | 2076-3921 | |
dc.identifier.other | 10.3390/antiox10111758 | |
dc.identifier.uri | https://repository.up.ac.za/handle/2263/85966 | |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en_US |
dc.subject | Epicardial adipose tissue | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Exercise | en_US |
dc.subject | Physical activity | en_US |
dc.subject | Epicardial fat thickness (EFT) | en_US |
dc.subject | Cardiovascular disease (CVD) | en_US |
dc.title | Physical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases : oxidative stress and inflammation emerge as major therapeutic targets | en_US |
dc.type | Article | en_US |