• Variations in pelvic floor thickness in relation to bony dimensions in South African women : using computed tomography scans 

  Kobedi, Ruth; Jagesur, Suvasha; Abdool, Zeelha; Oettle, Jacobus; Oettle, Anna C. (Spanish Association of Anatomy, 2024-07)

  Pelvic floor disorders (PFDs) are a common reason for urogynaecological consultation around the world, especially in elderly women. These disorders have been associated with disruption to the structural integrity of the ...
• Causation of term perinatal hypoxic-ischaemic basal ganglia and thalamus injury in the context of cerebral palsy litigation : position statement 

  Bhorat, Ismail; Buchmann, E.; Frank, K.; Soma-Pillay, Priya; Nicolaou, E.; Pistorius, L.; Smuts, Izelle (Health and Medical Publishing Group, 2023-09)

  Basal ganglia and thalamus (BGT) hypoxic-ischaemic brain injury is currently the most contentious issue in cerebral palsy (CP) litigation in South Africa (SA), and merits a consensus response based on the current available ...
• Visual inspection using naked eye and colposcopy as a predictor of high-grade lesions on final histology in HIV-positive and -negative South African women 

  Adams, Robyn A.; Dreyer, Greta; Snyman, Leon Cornelius; Visser, Cathy; Dreyer, G.J.; Breidenthal, Anne G.; Frenzel, C.; Van der Merwe, Frederick; Botha, Matthys H. (Medpharm Publications, 2023-06)

  BACKGROUND: Although potentially preventable, cervical cancer is the fourth most common cancer among women globally and a leading cause of cancer-related deaths. Women living in resource-limited countries are especially ...
• Simplicity sacrificed in the FIGO 2023 endometrial cancer staging : demystifying the complexity of twelve stages and seventeen substages 

  Dreyer, Greta; Snyman, Leon Cornelius (MedPharm Publications, 2023)

  Endometrial cancer incidence is rapidly rising globally, and in recent years, research has gained significant momentum. Surgical techniques, histopathology classification, risk stratification and understanding of different ...
• Response to 'Commentary on the published position statement regarding the pathogenesis of fetal basal ganglia- thalamic hypoxic-ischaemic injury' (Anthony et al.) 

  Bhorat, I.; Buchmann, E.; Frank, K.; Soma-Pillay, Priya; Nicolaou, E.; Pistorius, L.; Smuts, Izelle (Health and Medical Publishing Group, 2024-01)

  No abstract available.
• From pre-implementation to institutionalization : lessons From sustaining a perinatal audit program in South Africa 

  Kinney, Mary; George, Asha S.; Rhoda, Natasha R.; Pattinson, Robert Clive; Bergh, Anne-Marie (Johns Hopkins University Press, 2023-04)

  INTRODUCTION : Maternal and perinatal death surveillance and response (MPDSR), or related forms of maternal and perinatal death audits, can strengthen health systems. We explore the history of initiating, scaling up, ...
• Disease progression promotes changes in adipose tissue signatures in type 2 diabetic (db/db) mice : the potential pathophysiological role of batokines 

  Ziqubu, Khanyisani; Dludla, Phiwayinkosi V.; Moetlediwa, Marakiya T.; Nyawo, Thembeka A.; Pheiffer, Carmen; Jack, Babalwa U.; Nkambule, Bongani; Mazibuko-Mbeje, Sithandiwe E. (Elsevier, 2023-01)

  Unlike the white adipose tissue (WAT) which mainly stores excess energy as fat, brown adipose tissue (BAT) has become physiologically important and therapeutically relevant for its prominent role in regulating energy ...
• Feasibility and acceptability of an HPV self-testing strategy : lessons from a research context to assess for ability to implement into primary care at a national level in Botswana 

  Luckett, Rebecca; Ramogola-Masire, Doreen; Harris, Devon A.; Gompers, Annika; Gaborone, Kelebogile; Mochoba, Lorato; Ntshese, Lapelo; Mathoma, Anikie; Kula, Maduke; Shapiro, Roger; Larson, Elysia (Frontiers Media, 2024-01)

  BACKGROUND : The WHO strategy for cervical cancer elimination strives to achieve 70% coverage with high-performance cervical screening. While few low- and middle-income countries have achieved this, high-risk human ...
• In uncharted territory “together each achieves more” : a United Nations interagency collaboration for continuity of maternal and newborn health services during the coronavirus pandemic in the Eastern and Southern Africa region 

  Bergh, Anne-Marie; Gohar, Fatima; Kidula, Nancy A.; Abdullah, Muna (Frontiers Media, 2023-08-31)

  The frangible collaboration between three United Nations agencies (UNICEF, UNFPA and WHO) in the Eastern and Southern Africa Region was strengthened by the outbreak of the coronavirus pandemic. The aim was to combine ...
• The maternal microbiome and gestational diabetes mellitus : cause and effect 

  Dias, Stephanie; Pheiffer, Carmen; Adam, Sumaiya (MDPI, 2023-09)

  Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, ...
• Therapeutic effects of curcumin derivatives against obesity and associated metabolic complications : a review of in vitro and in vivo studies 

  Moetlediwa, Marakiya T.; Ramashia, Rudzani; Pheiffer, Carmen; Titinchi, Salam J. J.; Mazibuko-Mbeje, Sithandiwe E.; Jack, Babalwa U. (MDPI, 2023-09)

  Obesity is a major cause of morbidity and mortality globally, increasing the risk for chronic diseases. Thus, the need to identify more effective anti-obesity agents has spurred significant interest in the health-promoting ...
• Cyclopia intermedia (Honeybush) induces uncoupling protein 1 and peroxisome proliferator-activated receptor alpha expression in obese diabetic female db/db mice 

  Jack, Babalwa Unice; Ramharack, Pritika; Malherbe, Christiaan; Gabuza, Kwazi; Joubert, Elizabeth; Pheiffer, Carmen (MDPI, 2023-02)

  Previously, we reported that a crude polyphenol-enriched fraction of Cyclopia intermedia (CPEF), a plant consumed as the herbal tea, commonly known as honeybush, reduced lipid content in 3T3-L1 adipocytes and inhibited ...
• Validation of ASCL1 and LHX8 methylation analysis as primary cervical cancer screening strategy in South African women with human immunodeficiency virus 

  Vink, Frederique J.; Meijer, Chris J.L.M.; Lissenberg-Witte, Birgit I.; Visser, Cathy; Duin, Sylvia; Snyman, Leon Cornelius; Richter, Karin Louise; Van der Merwe, Frederick H.; Botha, Matthys H.; Steenbergen, Renske D.M.; Dreyer, Greta (Oxford University Press, 2023-02-01)

  BACKGROUND : Compared with women who are human immunodeficiency virus (HIV) negative, women with human immunodeficiency virus (WWH) have a higher human papillomavirus (HPV) prevalence and increased cervical cancer ...
• Enhancing cervical cancer prevention in South African women : primary HPV mRNA screening with different genotype combinations 

  Sorbye, Sveinung Wergeland; Falang, Bente Marie; Botha, Matthys H.; Snyman, Leon Cornelius; Van der Merwe, Haynes; Visser, Cathy; Richter, Karin Louise; Dreyer, Greta (MDPI, 2023-11-17)

  BACKGROUND : Cervical cancer prevention in regions with limited access to screening and HPV vaccination necessitates innovative approaches. This study explored the potential of a test-and-treat strategy using mRNA HPV tests ...
• Mapping of radiation oncology and gynecologic oncology services available to treat the growing burden of cervical cancer in Africa 

  Anakwenze, Chidinma P.; Allanson, Emma; Ewongwo, Agnes; Lumley, Christian; Bazzett-Matabele, Lisa; Msadabwe, Susan C.; Kamfwa, Paul; Shouman, Tarek; Lombe, Dorothy; Rubagumya, Fidel; Polo, Alfredo; Ntekim, Atara; Vanderpuye, Verna; Ghebre, Rahel; Kochbati, Lofti; Awol, Munir; Gnangnon, Freddy Houehanou Rodrigue; Snyman, Leon Cornelius; Domgue, Joel Fokom; Incrocci, Luca; Ndlovu, Ntokozo; Razakanaivo, Malala; Abdel-Wahab, May; Trimble, Edward; Schmeler, Kathleen; Simonds, Hannah; Grover, Surbhi (Elsevier, 2024-03)

  PURPOSE: To meet the demand for cervical cancer care in Africa, access to surgical and radiation therapy services needs to be understood. We thus mapped the availability of gynecologic and radiation therapy equipment and ...
• Comparison of obstetric and perinatal outcomes in women with diabetes at Steve Biko Academic Hospital 

  Malaza, Nompumelelo; Pheiffer, Carmen; Dias, S.; Adam, Sumaiya (Health and Medical Publishing Group, 2023-06)

  BACKGROUND : Diabetes and obesity in pregnancy have been associated with increased rates of adverse maternal and neonatal outcomes compared with women with normoglycaemia and normal weight. OBJECTIVE : To investigate the ...
• A research agenda to improve incidence and outcomes of assisted vaginal birth 

  Betrán, Ana Pilar; Torloni, Maria Regina; Althabe, Fernando; Altieri, Elena; Arulkumaran, Sabaratnam; Ashraf, Fatema; Bailey, Patricia; Bucagu, Maurice; Clark, Emma; Changizi, Nasrin; Churchill, Robyn; Dominico, Sunday; Downe, Soo; Draycott, Tim; Faye, Arfang; Feeley, Claire; Geelhoed, Diederike; Gherissi, Atf; Gholbzouri, Karima; Grupta, Gagan; Hailegebriel, Tedbabe Degefie; Hanson, Claudia; Hartmann, Katharina; Hassan, Lubna; Hofmeyr, George Justus; Jayathilaka, Anoma Chandani; Kabore, Charles; Kidula, Nancy; Kingdon, Carol; Kuzmenko, Oleg; Lumbiganon, Pisake; Mola, Glen D.L.; Moran, Allisyn; De Muncio, Bremen; Nolens, Barbara; Opiyo, Newton; Pattinson, Robert Clive; Romero, Mariana; Van Roosmalen, Jos; Siaulys, Monica M.; Camelo, Jose Simon; Smith, Jeffrey; Sobel, Howard L.; Sobhy, Soha; Sosa, Claudio; Souza, Joao Paulo; Hoope-Bender, Petra Ten; Thangaratinam, Shakila; Varallo, John; Wright, Alison; Yates, Ann; Oladapo, Olufemi O. (World Health Organization, 2023-11)

  Access to emergency obstetric care, including assisted vaginal birth and caesarean birth, is crucial for improving maternal and childbirth outcomes. However, although the proportion of births by caesarean section has ...
• Implementation of continuous-wave Doppler ultrasound to detect the high-risk foetus in the low-risk mother : lessons from South Africa 

  Hlongwane, T.M.A.G. (Tsakane); Pattinson, Robert Clive; Bergh, Anne-Marie (BMC, 2023-05-27)

  INTRODUCTION : Detecting the risk of stillbirth during pregnancy remains a challenge. Continuous-wave Doppler ultrasound (CWDU) can be used to screen for placental insufficiency, which is a major cause of stillbirths in ...
• A high fat, high sugar diet induces hepatic peroxisome proliferator-activated receptor gamma coactivator 1-alpha promoter hypermethylation in male Wistar rats 

  Abrahams, Yoonus; Willmer, Tarryn; Patel, Oelfah; Samodien, Ebrahim; Muller, Christo J.F.; Windvogel, Shantal; Johnson, Rabia; Pheiffer, Carmen (Elsevier, 2023-11)

  Previously we reported that a high fat, high sugar (HFHS) diet induced adiposity, hyperinsulinaemia, hyperleptinaemia, hypertriglyceridaemia and increased liver mass in male Wistar rats. In the present study, the mechanisms ...
• Utility of extended HPV genotyping as primary cervical screen in an unscreened population with high HIV co-infection rate 

  Botha, Matthys Hendrik; Van der Merwe, Frederick H.; Snyman, Leon Cornelius; Dreyer, Gerrit J.; Visser, Cathy; Dreyer, Greta (Lippincott, Williams & Wilkins, 2023-07)

  OBJECTIVE : Screening with primary human papillomavirus (HPV) testing has been evaluated in highly prescreened populations with lower HPV and HIV prevalence than what is the case in South Africa. High prevalence of HPV and ...

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