dc.contributor.author |
Grinevich, Valery
|
|
dc.contributor.author |
Ludwig, Mike
|
|
dc.date.accessioned |
2021-07-20T14:14:39Z |
|
dc.date.issued |
2021-11 |
|
dc.description.abstract |
Classically, hypothalamic neuroendocrine cells that synthesise oxytocin and vasopressin were categorised in two major cell types: the magnocellular and parvocellular neurones. It was assumed that magnocellular neurones project exclusively to the pituitary gland where they release oxytocin and vasopressin into the systemic circulation. The parvocellular neurones, on the other hand, project within the brain to regulate discrete brain circuitries and behaviours. Within the last few years, it has become evident that the classical view of these projections is outdated. It is now clear that oxytocin and vasopressin in the brain are released extrasynaptically from dendrites and from varicosities in distant axons. The peptides act principally to modulate information transfer through conventional synapses (such as glutamate synapses) by actions at respective receptors that may be preferentially localised to synaptic regions (on either side of the synapse) to alter the ‘gain’ of conventional synapses. |
en_ZA |
dc.description.department |
Immunology |
en_ZA |
dc.description.embargo |
2022-06-17 |
|
dc.description.librarian |
hj2021 |
en_ZA |
dc.description.sponsorship |
Biotechnology and Biological Sciences Research Council and Deutsche Forschungsgemeinschaft. |
en_ZA |
dc.description.uri |
http://wileyonlinelibrary.com/journal/jne |
en_ZA |
dc.identifier.citation |
Grinevich V, Ludwig M. The multiple
faces of the oxytocin and vasopressin systems in the brain.
Journal of Neuroendocrinology 2021;33:e13004. https://doi.org/10.1111/jne.13004. |
en_ZA |
dc.identifier.issn |
0953-8194 (print) |
|
dc.identifier.issn |
1365-2826 (online) |
|
dc.identifier.other |
10.1111/jne.13004 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/80901 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Wiley |
en_ZA |
dc.rights |
© 2021 British Society for Neuroendocrinology. This is the pre-peer reviewed version of the following article : The multiple
faces of the oxytocin and vasopressin systems in the brain.
Journal of Neuroendocrinology 2021;2021;33:e13004. https://doi.org/10.1111/jne.13004. The definite version is available at : http://wileyonlinelibrary.com/journal/jne26. |
en_ZA |
dc.subject |
Anatomy |
en_ZA |
dc.subject |
Axonal release |
en_ZA |
dc.subject |
Magnocellular |
en_ZA |
dc.subject |
Oxytocin |
en_ZA |
dc.subject |
Parvocellular |
en_ZA |
dc.subject |
Projections |
en_ZA |
dc.subject |
Somato-dendritic release |
en_ZA |
dc.subject |
Vasopressin |
en_ZA |
dc.title |
The multiple faces of the oxytocin and vasopressin systems in the brain |
en_ZA |
dc.type |
Postprint Article |
en_ZA |