SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Show simple item record Wibmer, Constantinos Kurt Ayres, Frances Hermanus, Tandile Madzivhandila, Mashudu Kgagudi, Prudence Oosthuysen, Brent Lambson, Bronwen E. De Oliveira, Tulio Vermeulen, Marion Van der Berg, Karin Rossouw, Theresa M. Boswell, Michael Ueckermann, Veronica Meiring, Susan Von Gottberg, Anne Cohen, Cheryl Morris, Lynn Bhiman, Jinal N. Moore, Penny L. 2021-04-07T07:26:39Z 2021
dc.description Supplementary Information: Supplementary Figs. 1 and 2 en_ZA
dc.description.abstract SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines. en_ZA
dc.description.department Immunology en_ZA
dc.description.department Internal Medicine en_ZA
dc.description.embargo 2021-09-02
dc.description.librarian hj2021 en_ZA
dc.description.sponsorship The South African Medical Research Council, the Wellcome Trust, US Centers for Disease Control and Prevention and the ELMA South Africa Foundation. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Wibmer, C.K., Ayres, F., Hermanus, T. et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. Nature Medicine (2021). NYP. en_ZA
dc.identifier.issn 1078-8956 (print)
dc.identifier.issn 1546-170X (online)
dc.identifier.other 10.1038/s41591-021-01285-x
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © The Author(s), under exclusive licence to Springer Nature America, Inc. 2021 en_ZA
dc.subject Infectious diseases en_ZA
dc.subject COVID-19 pandemic en_ZA
dc.subject Coronavirus disease 2019 (COVID-19) en_ZA
dc.subject Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) en_ZA
dc.title SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma en_ZA
dc.type Postprint Article en_ZA

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