• Apoptotic profiling of chronic myeloid leukaemia patients' platelets ex vivo before and after treatment with Imatinib 

  Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Becker, Piet J.; Joubert, Anna Margaretha (Wiley, 2021-06)

  Chronic myeloid leukaemia (CML) is a malignancy of the haematopoietic stem cells. The first line of treatment for CML, especially in developing countries, remains the first-generation tyrosine kinase inhibitor, Imatinib. ...
• Adiponectin DNA methylation in South African women with gestational diabetes mellitus : effects of HIV infection 

  Dias, Stephanie Charmaine; Adam, Sumaiya; Abrahams, Yoonus; Rheeder, Paul; Pheiffer, Carmen (Public Library of Science, 2021-03)

  DNA methylation is increasingly recognized as a potential biomarker of metabolic disease. However, there is limited information on the impact of human immunodeficiency virus (HIV) infection on the candidacy of DNA ...
• Cefdinir and β-lactamase inhibitor independent efficacy against mycobacterium tuberculosis 

  Srivastava, Shashikant; Thomas, Tania; Howe, Dave; Malinga, Lesibana Anthony; Raj, Prithvi; Alffenaar, Jan-Willem; Gumbo, Tawanda (Frontiers Media, 2021-06-07)

  BACKGROUND : There is renewed interest in repurposing β-lactam antibiotics for treatment of tuberculosis (TB). We investigated efficacy of cefdinir, that withstand the β-lactamase enzyme present in many bacteria, against ...
• Pulmonary toxicities associated with the use of immune checkpoint inhibitors: an update from the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer 

  Rapoport, Bernardo Leon; Shannon, Vickie R.; Cooksley, Tim; Johnson, Douglas B.; Anderson, Lindsay; Blidner, Ada Gabriela; Tintinger, Gregory Ronald; Anderson, Ronald (Frontiers Media, 2021-10)

  The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, with agents such as nivolumab, pembrolizumab, and cemiplimab targeting programmed cell death protein-1 (PD-1) and durvalumab, ...
• The COVID-19 treatment landscape : a South African perspective on a race against time 

  Hendricks, Candice Laverne; Herd, Candice; Nel, Marcel; Tintinger, Gregory Ronald; Pepper, Michael Sean (Frontiers Media, 2021-02-19)

  The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which ...
• Submission for special issue : The role of platelet activation in the pathophysiology of HIV, tuberculosis, and pneumococcal disease. Bedaquiline suppresses ADP-mediated activation of human platelets in vitro via interference with phosphatidylinositol 3-kinase 

  Tintinger, Gregory Ronald; Theron, Annette J.; Steel, Helen C.; Cholo, Moloko C.; Nel, Jan Gert; Feldman, Charles; Anderson, Ronald (MDPI, 2021-02-26)

  Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated ...
• No association between ADIPOQ or MTHFR polymorphisms and gestational diabetes mellitus in South African women 

  Dias, Stephanie Charmaine; Adam, Sumaiya; Rheeder, Paul; Pheiffer, Carmen (Dove Medical Press, 2021)

  PURPOSE : Gestational diabetes mellitus (GDM) is a growing public health concern. GDM affects approximately 14% of pregnancies globally, and without effective treatment, is associated with short- and long-term complications ...
• Evaluating the pharmacoeconomic impact of nutrient supplementation post-operatively on patients receiving Roux-Y gastric bypass vs. biliopancreatic diversion with duodenal switch 

  Van Vollenstee, Fiona A.; Van der Merwe, Maria-Teresa (Springer, 2021-06)

  BACKGROUND : Without the needed medical support, bariatric surgery can be associated with post-operative malnutrition and associated nutrient deficiencies. We aimed to evaluate the cost difference of perioperative infusion ...
• Role and merits of green based nanocarriers in cancer treatment 

  Elbagory, Abdulrahman M.; Marima, Rahaba; Dlamini, Zodwa (MDPI, 2021-11-13)

  The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the ...
• Comparison of targeted metagenomics and IS-Pro methods for analysing the lung microbiome 

  Goolam Mahomed, Tanweer; Peters, Remco P.H.; Pretorius, G.H.J.; Mahomed, A. Goolam; Ueckermann, Veronica; Kock, Marleen M.; Ehlers, Marthie Magdaleen (BioMed Central, 2021-08-18)

  BACKGROUND : Targeted metagenomics and IS-Pro method are two of the many methods that have been used to study the microbiome. The two methods target different regions of the 16 S rRNA gene. The aim of this study was to ...
• Mitotic syndicates Aurora Kinase B (AURKB) and mitotic arrest deficient 2 like 2 (MAD2L2) in cohorts of DNA damage response (DDR) and tumorigenesis 

  Marima, Rahaba; Hull, Rodney; Penny, Clement; Dlamini, Zodwa (Elsevier, 2021-01)

  Aurora Kinase B (AURKB) and Mitotic Arrest Deficient 2 Like 2 (MAD2L2) are emerging anticancer therapeutic targets. AURKB and MAD2L2 are the least well studied members of their protein families, compared to AURKA and ...
• Lymphopenia and IgG2 subclass deficiency in patients with severe COVID-19 pneumonia 

  Taban, E.M.; Tintinger, Gregory Ronald; Joseph, Darren; Gaylard. P.; Richards, D. (South African Medical Association NPC, 2021-03-29)

  BACKGROUND : COVID-19 caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) manifests with a range of disease severities. A small proportion of COVID-19 patients are severely ill; however, a ...
• Adverse effects of biologic anti-inflammatory agents on the respiratory system : a review 

  Joseph, Darren; Tintinger, Gregory Ronald; Ker, James A.; Pannell, N. (South African Medical Association NPC, 2021)

  The therapy of autoimmune rheumatological conditions has undergone significant changes with the introduction of biologic antiinflammatory agents including cytokine antagonists and agents that interfere with the function ...
• Dance as physical exercise for older people 

  Viljoen, Margaretha; Levay, Peter Ferenc (Academy of Science of South Africa, 2021-11)

  The importance of adequate physical activity for older people cannot be overestimated. Evidence exists that physical exercise can improve quality of life; benefit brain areas involved with executive control; delay the ...
• P300 event-related potentials in normal-hearing adults with Type 2 diabetes mellitus 

  Van der Westhuizen, Natasha; Biagio-de Jager, Leigh; Rheeder, Paul (American Speech-Language-Hearing Association, 2020-06)

  BACKGROUND : P300 event-related potentials can be used to measure auditory processing speed, working memory, and attention. PURPOSE : The purpose of the study was to compare P300 event-related potentials in normal-hearing ...
• Sustaining essential healthcare in Africa during the COVID-19 pandemic 

  Ongole, J.J.; Rossouw, Theresa M.; Fourie, P.B. (Petrus Bernardus); Stoltz, Anton Carel; Hugo, Johannes F.M.; Marcus, Tessa S. (International Union Against Tuberculosis and Lung Disease, 2020-06)

  No abstract available.
• Factors influencing adolescent girls and young women’s participation in a combination HIV prevention intervention in South Africa 

  Appollis, Tracy McClinton; Duby, Zoe; Jonas, Kim; Dietrich, Janan; Maruping, Kealeboga; Abdullah, Fareed; Slingers, Nevilene; Mathews, Catherine (BMC, 2021-02)

  BACKGROUND: For interventions to reach those they are intended for, an understanding of the factors that influence their participation, as well as the facilitators and barriers of participation are needed. This study ...
• Making the case for an obstetric medicine subspecialty in South Africa 

  Zamparini, J; Wium, Lizemarie (Health and Medical Publishing Group, 2020-12)

  Obstetric medicine is a subspecialty of internal medicine that involves the management of medical conditions that may affect the course of pregnancy. It is an established subspecialty in many parts of the world, with ...
• Suboptimal control for patients with type 2 diabetes in the Central Chronic Medicine Dispensing programme in South Africa 

  Ngassa Piotie, Patrick; Webb, Elizabeth M.; Rheeder, Paul (AOSIS, 2021-03)

  BACKGROUND: In South Africa, the Central Chronic Medicine Dispensing and Distribution (CCMDD) programme allows stable patients with non-communicable diseases, including type 2 diabetes mellitus (T2DM), to collect their ...
• Efavirenz induces DNA damage response pathway in lung cancer 

  Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Impact Journals, 2020-10)

  The cell-cycle related genes are potential gene targets in understanding the effects of efavirenz (EFV) in lung cancer. The present study aimed at investigating the expression changes of cell-cycle related genes in ...

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