dc.contributor.author |
Magwira, C.A. (Cliff)
|
|
dc.contributor.author |
Taylor, Maureen B.
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|
dc.date.accessioned |
2019-01-23T10:09:05Z |
|
dc.date.issued |
2018-06 |
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dc.description.abstract |
The introduction of oral rotavirus vaccines (ORVVs) has led to a reduction in number of hospitalisations and deaths due to rotavirus (RV) infection. However, the efficacy of the vaccines has been varied with low-income countries showing significantly lower efficacy as compared to high-income countries. The reasons for the disparity are not fully understood but are thought to be multi-factorial. In this review article, we discuss the concept that the disparity in the efficacy of oral rotavirus vaccines between the higher and lower socio-economical countries could be due the nature of the bacteria that colonises and establishes in the gut early in life. We further discuss recent studies that has demonstrated significant correlations between the composition of the gut bacteria and the immunogenicity of oral vaccines, and their implications in the development of novel oral RV vaccines or redesigning the current ones for maximum impact. |
en_ZA |
dc.description.department |
Medical Virology |
en_ZA |
dc.description.embargo |
2019-06-07 |
|
dc.description.librarian |
hj2019 |
en_ZA |
dc.description.sponsorship |
The Rand Water Chair in Public Health and University of Pretoria. |
en_ZA |
dc.description.uri |
http://www.elsevier.com/locate/vaccine |
en_ZA |
dc.identifier.citation |
Magwira, C.A. & Taylor, M.B. 2018, 'Composition of gut microbiota and its influence on the immunogenicity of oral rotavirus vaccines', Vaccine, vol. 36, no. 24, pp. 3427-3433. |
en_ZA |
dc.identifier.issn |
0264-410X (print) |
|
dc.identifier.issn |
1873-2518 (online) |
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dc.identifier.other |
10.1016/j.vaccine.2018.04.091 |
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dc.identifier.uri |
http://hdl.handle.net/2263/68216 |
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dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2018 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Vaccine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Vaccine, vol. 36, no. 24, pp. 3427-3433, 2018. doi : 10.1016/j.vaccine.2018.04.091. |
en_ZA |
dc.subject |
Oral rotavirus vaccine (ORVV) |
en_ZA |
dc.subject |
Gut microbiota |
en_ZA |
dc.subject |
Immunogenicity |
en_ZA |
dc.subject |
Efficacy |
en_ZA |
dc.subject |
Viral infection |
en_ZA |
dc.subject |
Immunity |
en_ZA |
dc.subject |
Higher socio-economic countries |
en_ZA |
dc.subject |
Lower socio-economic countries |
en_ZA |
dc.subject |
Segmented filamentous bacteria |
en_ZA |
dc.subject |
T-cell responses |
en_ZA |
dc.subject |
Intestinal microbiota |
en_ZA |
dc.subject |
Immune responses |
en_ZA |
dc.subject |
Escherichia coli |
en_ZA |
dc.subject |
Gnotobiotic pigs |
en_ZA |
dc.subject |
African infants |
en_ZA |
dc.subject |
Secretor status |
en_ZA |
dc.subject |
Colonization |
en_ZA |
dc.title |
Composition of gut microbiota and its influence on the immunogenicity of oral rotavirus vaccines |
en_ZA |
dc.type |
Postprint Article |
en_ZA |