dc.contributor.author |
Jansen van Vuren, Petrus
|
|
dc.contributor.author |
Allam, Mushal
|
|
dc.contributor.author |
Wiley, Michael R.
|
|
dc.contributor.author |
Ismail, Arshad
|
|
dc.contributor.author |
Storm, Nadia
|
|
dc.contributor.author |
Birkhead, Monica
|
|
dc.contributor.author |
Markotter, Wanda
|
|
dc.contributor.author |
Palacios, Gustavo
|
|
dc.contributor.author |
Paweska, Janusz Tadeusz
|
|
dc.date.accessioned |
2018-09-25T13:09:54Z |
|
dc.date.available |
2018-09-25T13:09:54Z |
|
dc.date.issued |
2018-06-25 |
|
dc.description.abstract |
Recently a number of novel adenoviruses have been isolated from diverse bat species and from diverse
geographical locations. We describe the isolation of a novel adenovirus (Family Adenoviridae, genus
Mastadenovirus) from a pool of liver and spleen tissue of an apparently healthy wild-caught Egyptian
fruit bat (Rousettus aegyptiacus) in South Africa. Genetically the virus is most closely related to four
mastadenoviruses recently isolated in China, from Miniopterus schreibersi and Rousettus leschenaultii
bats, which are highly divergent from previously identified bat adenoviruses. The length of the
Rousettus aegyptiacus adenovirus-3085 (RaegAdV-3085) genome, at 29,342 bp is similar to its closest
relatives, and contains 27 open reading frames. The RaegAdV-3085 genome has a low G + C content
(36.4%) relative to other viruses in the genus (between 43.6 and 63.9%) but similar to its closest
relatives. The inverted terminal repeat (ITR) of RaegAdV-3085 is only 40 bp compared to between 61
and 178 bp of its closest relatives. The discovery of RaegAdV-3085 expands the diversity of known
adenoviruses in bats and might represent a member of a new mastadenovirus species in bats. |
en_ZA |
dc.description.department |
Medical Virology |
en_ZA |
dc.description.librarian |
am2018 |
en_ZA |
dc.description.sponsorship |
The project is jointly funded by the following
grants awarded to: Janusz T. Paweska (CDC Global Disease Detection program, GDD 5U19 GH000571–
05/96667) and Petrus Jansen van Vuren (South African National Research Foundation, Incentive Funding for
Rated Researchers, Grant UID 85544). This work was financially supported in part by the National Research
Foundation (NRF) of South Africa: the South African Research Chair held by WM, grant no. 98339, as well as
grant numbers 92524, 85756, and 91496. |
en_ZA |
dc.description.uri |
http://www.nature.com/srep |
en_ZA |
dc.identifier.citation |
Van Vuren, P.J., Allam, M., Wiley, M.R. et al. 2018, 'A novel adenovirus isolated from the Egyptian fruit bat in South Africa is closely related to recent isolates from China', Scientific Reports, vol. 8, art. 9584, pp. 1-8. |
en_ZA |
dc.identifier.issn |
2045-2322 (online) |
|
dc.identifier.other |
10.1038/s41598-018-27836-w |
|
dc.identifier.uri |
http://hdl.handle.net/2263/66643 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Nature Publishing Group |
en_ZA |
dc.rights |
© The Author(s) 2018. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International
License. |
en_ZA |
dc.subject |
Novel adenoviruses |
en_ZA |
dc.subject |
Bat |
en_ZA |
dc.subject |
Isolation |
en_ZA |
dc.subject |
Inverted terminal repeat |
en_ZA |
dc.subject |
Egyptian fruit bat (Rousettus aegyptiacus) |
en_ZA |
dc.subject |
South Africa (SA) |
en_ZA |
dc.title |
A novel adenovirus isolated from the Egyptian fruit bat in South Africa is closely related to recent isolates from China |
en_ZA |
dc.type |
Article |
en_ZA |