Dilute Russel viper venom time analysis in a haematology laboratory : an audit

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dc.contributor.author Kruger, Welma
dc.contributor.author Meyer, P.W.A. (Pieter Willem Adriaan)
dc.contributor.author Nel, Jan Gert
dc.date.accessioned 2018-08-03T07:10:13Z
dc.date.issued 2018-08
dc.description.abstract INTRODUCTION : To determine whether the current set of evaluation criteria used for dilute Russel Viper Venom Time (dRVVT) investigations in the routine laboratory meet expectation and identify possible shortcomings. METHODS : All dRVVT assays requested from January 2015 to December 2015 were appraised in this cross‐sectional study. The raw data panels were compared with the new reference interval, established in 2016, to determine the sequence of assays that should have been performed. The interpretive comments were audited, and false‐negative reports identified. Interpretive comments according to three interpretation guidelines were compared. The reagent cost per assay was determined, and reagent cost wastage, due to redundant tests, was calculated. RESULTS : Only ~9% of dRVVT results authorized during 2015 had an interpretive comment included in the report. ~15% of these results were false‐negative interpretations. There is a significant statistical difference in interpretive comments between the three interpretation methods. Redundant mixing tests resulted in R 7477.91 (~11%) reagent cost wastage in 2015. CONCLUSIONS : We managed to demonstrate very evident deficiencies in our own practice and managed to establish a standardized workflow that will potentially render our service more efficient and cost effective, aiding clinicians in making improved treatment decisions and diagnoses. Furthermore, it is essential that standard operating procedures be kept up to date and executed by all staff in the laboratory. en_ZA
dc.description.department Haematology en_ZA
dc.description.department Immunology en_ZA
dc.description.embargo 2019-08-01
dc.description.librarian hj2018 en_ZA
dc.description.uri http://wileyonlinelibrary.com/journal/ijlh en_ZA
dc.identifier.citation Kruger, W., Meyer, P.W.A. & Nel, J.G. 2018, 'Dilute Russel viper venom time analysis in a haematology laboratory : an audit', International Journal of Laboratory Hematology, vol. 40, no. 4, pp. 453-458. en_ZA
dc.identifier.issn 1751-5521 (print)
dc.identifier.issn 1751-553X (online)
dc.identifier.other 10.1111/ijlh.12825
dc.identifier.uri http://hdl.handle.net/2263/66067
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2018 John Wiley & Sons Ltd. This is the pre-peer reviewed version of the following article : 'Dilute Russel viper venom time analysis in a haematology laboratory : an audit', International Journal of Laboratory Hematology, vol. 40, no. 4, pp. 453-458, 2018, doi : 10.1111/ijlh.12825. The definite version is available at : http://wileyonlinelibrary.com/journal/ijlh. en_ZA
dc.subject Russel viper venom time (dRVVT) en_ZA
dc.subject Anti‐phospholipid syndrome en_ZA
dc.subject Lupus inhibitor en_ZA
dc.title Dilute Russel viper venom time analysis in a haematology laboratory : an audit en_ZA
dc.type Postprint Article en_ZA


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