dc.contributor.author |
Senthebane, Dimakatso Alice
|
|
dc.contributor.author |
Rowe, Arielle
|
|
dc.contributor.author |
Thomford, Nicholas Ekow
|
|
dc.contributor.author |
Shipanga, Hendrina
|
|
dc.contributor.author |
Munro, Daniella
|
|
dc.contributor.author |
Al Mazeedi, Mohammad A.M.
|
|
dc.contributor.author |
Almazyadi, Hashim A.M.
|
|
dc.contributor.author |
Kallmeyer, Karlien
|
|
dc.contributor.author |
Dandara, Collet
|
|
dc.contributor.author |
Pepper, Michael Sean
|
|
dc.contributor.author |
Parker, M. Iqbal
|
|
dc.contributor.author |
Dzobo, Kevin
|
|
dc.date.accessioned |
2017-10-09T07:19:35Z |
|
dc.date.available |
2017-10-09T07:19:35Z |
|
dc.date.issued |
2017-07-21 |
|
dc.description.abstract |
Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues
to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic
alterations which affect drug uptake, metabolism and export of drugs at the cellular levels. While
most research has focused on tumor cell autonomous mechanisms of chemoresistance, the tumor
microenvironment has emerged as a key player in the development of chemoresistance and in
malignant progression, thereby influencing the development of novel therapies in clinical oncology.
It is not surprising that the study of the tumor microenvironment is now considered to be as important
as the study of tumor cells. Recent advances in technological and analytical methods, especially
‘omics’ technologies, has made it possible to identify specific targets in tumor cells and within
the tumor microenvironment to eradicate cancer. Tumors need constant support from previously
‘unsupportive’ microenvironments. Novel therapeutic strategies that inhibit such microenvironmental
support to tumor cells would reduce chemoresistance and tumor relapse. Such strategies can target
stromal cells, proteins released by stromal cells and non-cellular components such as the extracellular
matrix (ECM) within the tumor microenvironment. Novel in vitro tumor biology models that
recapitulate the in vivo tumor microenvironment such as multicellular tumor spheroids, biomimetic
scaffolds and tumor organoids are being developed and are increasing our understanding of cancer
cell-microenvironment interactions. This review offers an analysis of recent developments on the
role of the tumor microenvironment in the development of chemoresistance and the strategies to
overcome microenvironment-mediated chemoresistance. We propose a systematic analysis of the
relationship between tumor cells and their respective tumor microenvironments and our data show that, to survive, cancer cells interact closely with tumor microenvironment components such as
mesenchymal stem cells and the extracellular matrix. |
en_ZA |
dc.description.department |
Immunology |
en_ZA |
dc.description.librarian |
am2017 |
en_ZA |
dc.description.sponsorship |
The National Research Foundation (NRF)
of South Africa (Grant Number: 91457: RCA13101656402), International Centre for Genetic Engineering and
Biotechnology (ICGEB) (Grant Number: 2015/0001), the South African Medical Research Council in terms of
the MRC’s Flagships Awards Project SAMRC-RFA-UFSP-01-2013/STEM CELLS, the SAMRC Extramural Unit
for Stem Cell Research and Therapy Unit, the National Research Foundation and the Institute for Cellular and
Molecular Medicine of the University of Pretoria and the University of Cape Town. |
en_ZA |
dc.description.uri |
http://www.mdpi.com/journal/ijms |
en_ZA |
dc.identifier.citation |
Senthebane, D.A., Rowe, A., Thomford, N.E., Shipanga, H., Munro, D., Al Mazeedi, M.A.M., Almazyadi, H.A.M., Kallmeyer, K., Dandara, C., Pepper, M.S., Parker, M.I. & Dzobo, K. 2017, 'The role of tumor microenvironment in chemoresistance : to survive, keep your enemies closer', International Journal of Molecular Sciences, vol. 18, art. no. 1586, pp. 1-30. |
en_ZA |
dc.identifier.issn |
1422-0067 (online) |
|
dc.identifier.other |
10.3390/ijms18071586 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/62614 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
MDPI Publishing |
en_ZA |
dc.rights |
© 2017 by the authors.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license. |
en_ZA |
dc.subject |
Chemoresistance |
en_ZA |
dc.subject |
Tumor microenvironment |
en_ZA |
dc.subject |
Tumor heterogeneity |
en_ZA |
dc.subject |
Mesenchymal stromal/stem cells (MSCs) |
en_ZA |
dc.subject |
Angiogenesis |
en_ZA |
dc.subject |
Extracellular matrix |
en_ZA |
dc.subject |
Clinical oncology |
en_ZA |
dc.subject |
Lung cancer |
en_ZA |
dc.subject |
Breast cancer cells |
en_ZA |
dc.subject |
Acute myeloid leukaemia |
en_ZA |
dc.subject |
Targeted drug delivery |
en_ZA |
dc.subject |
Extracellular matrix |
en_ZA |
dc.subject |
Hepatocellular carcinoma cells |
en_ZA |
dc.subject |
Pancreatic ductal adenocarcinoma (PDA) |
en_ZA |
dc.title |
The role of tumor microenvironment in chemoresistance : to survive, keep your enemies closer |
en_ZA |
dc.type |
Article |
en_ZA |