dc.contributor.author |
Richards, Guy A.
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|
dc.contributor.author |
Brink, Adrian J.
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|
dc.contributor.author |
McIntosh, Ross
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|
dc.contributor.author |
Steel, Helen C.
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|
dc.contributor.author |
Cockeran, Riana
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dc.date.accessioned |
2014-09-18T07:46:27Z |
|
dc.date.available |
2014-09-18T07:46:27Z |
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dc.date.issued |
2014-07 |
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dc.description.abstract |
Catheter-related blood stream infections increase morbidity, mortality, and costs. This study investigated whether Certofix® protect antimicrobial catheters carry a surface charge and whether this inhibits biofilm formation. The capacitance of the catheter surfaces was measured and, to determine if the catheters released ions, distilled water was passed through and current measured as a function of voltage. With probes touching the inner and outer surfaces, capacitance was not voltage-dependent, indicating surfaces were uncharged or carried a similar charge. When one probe penetrated the catheter wall, capacitance was weakly voltage-dependent, indicating the presence of a surface charge. Standard and charged catheters were also exposed to phosphate buffered saline as controls or 2×106 colony forming units/mL (in phosphate buffered saline) of six different microorganisms for 60 or 120 minutes. When the growth of detached bacteria was measured, biofilm formation was significantly reduced, (P<0.05), for charged catheters for all organisms. |
en_US |
dc.description.librarian |
hb2014 |
en_US |
dc.description.sponsorship |
B Braun Melsungen AG (Melsungen, Germany) supplied the catheters and sufficient funds to perform the biofilm studies in the form of an unrestricted grant. RC is supported by the National Research Foundation of South Africa. RM is supported by the National Research Foundation (SA) under the Nanotechnology Flagship Project grant and the University Research Council (Witwatersrand) |
en_US |
dc.description.uri |
http://www.dovepress.com/medical-devices-evidence-and-research-journal |
en_US |
dc.identifier.citation |
Richards, GA, Brink, AJ, McIntosh, R, Steel, HC & Cockeran, R 2014, 'Investigation of biofilm formation on a charged intravenous catheter relative to that on a similar but uncharged catheter', Medical Devices : Evidence and Research, vol. 7, no. 1, pp. 219-224. |
en_US |
dc.identifier.issn |
1179-1470 (online) |
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dc.identifier.other |
/10.2147/MDER.S63449 |
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dc.identifier.uri |
http://hdl.handle.net/2263/42028 |
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dc.language.iso |
en |
en_US |
dc.publisher |
Dove Medical Press |
en_US |
dc.rights |
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. |
en_US |
dc.subject |
Central venous catheters |
en_US |
dc.subject |
Electrical charge |
en_US |
dc.subject |
Biofilm |
en_US |
dc.title |
Investigation of biofilm formation on a charged intravenous catheter relative to that on a similar but uncharged catheter |
en_US |
dc.type |
Article |
en_US |