Glycation of fibrinogen in uncontrolled diabetic patients and the effects of glycaemic control on fibrinogen glycation

Pieters, Marlien; Van Zyl, Danie G.; Rheeder, Paul; Jerling, Johann C.; Loots, Du Toit; Van der Westhuizen, Francois Hendrikus; Gottsche, Louise T.; Weisel, John W.

dc.contributor.author	Pieters, Marlien
dc.contributor.author	Van Zyl, Danie G.
dc.contributor.author	Rheeder, Paul
dc.contributor.author	Jerling, Johann C.
dc.contributor.author	Loots, Du Toit
dc.contributor.author	Van der Westhuizen, Francois Hendrikus
dc.contributor.author	Gottsche, Louise T.
dc.contributor.author	Weisel, John W.
dc.date.accessioned	2007-08-15T06:52:32Z
dc.date.available	2007-08-15T06:52:32Z
dc.date.issued	2007
dc.description.abstract	Evidence exists for a relationship between glycaemic control and macrovascular disease. Non-enzymatic glycation of proteins may explain this relationship in part. We investigated the effect of blood glucose control, under out-patient conditions, on fibrinogen glycation as well as the relationship between glycated fibrinogen and glycaemic control using a new sensitive method for the measurement of glycated fibrinogen.	en
dc.description.sponsorship	The authors would like to thank the volunteers who took part in the study for their willingness and effort. We would also like to thank Sr. Dorothy Kekana for her hard work in recruiting subjects and in the execution of the intervention. Many thanks also to Dr. Rustem Litvinov and Dr. Robert Ariëns, for their expertise and input in analytic experiments and results. The study was funded by research funds from the North-West University and the University of Pretoria. Insulin was provided by Sanofi-Aventis, South Africa and Novo-Nordisk, South Africa and glucometers by Roche Diagnostics.	en
dc.format.extent	157371 bytes
dc.format.mimetype	application/pdf
dc.identifier.citation	Pieters, M, Van Zyl, DG, Rheeder, P, Jerling, JC, Loots, Du T, Van der Westhuizen, FH Gottsche, LT & Weisel, JW 2007, ‘Glycation of fibrinogen in uncontrolled diabetic patients and the effects of glycaemic control on fibrinogen glycation’, Thrombosis Research, vol. 120, no. 3, pp. 439-446 [http://www.sciencedirect.com/science/journal/00493848]	en
dc.identifier.issn	0049-3848
dc.identifier.other	10.1016/j.thromres.2006.10.016
dc.identifier.uri	http://hdl.handle.net/2263/3295
dc.language.iso	en	en
dc.publisher	Elsevier	en
dc.rights	Elsevier	en
dc.subject	Glycation	en
dc.subject	Glycaemic control	en
dc.subject	Glycated fibrinogen	en
dc.subject	Type 2 diabetes mellitus (T2DM)	en
dc.subject.lcsh	Diabetes -- Research -- South Africa
dc.subject.lcsh	Blood sugar monitoring -- South Africa
dc.subject.lcsh	Glycosylation
dc.subject.lcsh	Fibrinogen -- South Africa
dc.title	Glycation of fibrinogen in uncontrolled diabetic patients and the effects of glycaemic control on fibrinogen glycation	en
dc.type	Postprint Article	en