Glycation of fibrinogen in uncontrolled diabetic patients and the effects of glycaemic control on fibrinogen glycation

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Authors

Pieters, Marlien
Van Zyl, Danie G.
Rheeder, Paul
Jerling, Johann C.
Loots, Du Toit
Van der Westhuizen, Francois Hendrikus
Gottsche, Louise T.
Weisel, John W.

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Volume Title

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Elsevier

Abstract

Evidence exists for a relationship between glycaemic control and macrovascular disease. Non-enzymatic glycation of proteins may explain this relationship in part. We investigated the effect of blood glucose control, under out-patient conditions, on fibrinogen glycation as well as the relationship between glycated fibrinogen and glycaemic control using a new sensitive method for the measurement of glycated fibrinogen.

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Keywords

Glycation, Glycaemic control, Glycated fibrinogen, Type 2 diabetes mellitus (T2DM)

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Citation

Pieters, M, Van Zyl, DG, Rheeder, P, Jerling, JC, Loots, Du T, Van der Westhuizen, FH Gottsche, LT & Weisel, JW 2007, ‘Glycation of fibrinogen in uncontrolled diabetic patients and the effects of glycaemic control on fibrinogen glycation’, Thrombosis Research, vol. 120, no. 3, pp. 439-446 [http://www.sciencedirect.com/science/journal/00493848]