dc.contributor.author |
Petersen, Desiree C.
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dc.contributor.author |
Glashoff, Richard H.
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dc.contributor.author |
Sherestha, Sadeep
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dc.contributor.author |
Bergeron, Julie
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dc.contributor.author |
Laten, Anette
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dc.contributor.author |
Gold, Bert
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dc.contributor.author |
Janse van Rensburg, Estrelita
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dc.contributor.author |
Dean, Michael
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dc.contributor.author |
Hayes, Vanessa M.
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dc.date.accessioned |
2007-07-27T05:59:39Z |
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dc.date.available |
2007-07-27T05:59:39Z |
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dc.date.issued |
2005-12-15 |
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dc.description.abstract |
CXC chemokine ligand 12 (CXCL12), or stromal cell–derived factor 1 (SDF1), is the only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 gene (SDF1-3'A) has been associated with disease progression to AIDS in some studies, but not others. Mutations in the CXCR4 gene are generally rare and have not been implicated in HIV-1/AIDS pathogenesis. This study analyzed the SDF1-3'A SNP and performed mutation screening for
polymorphic markers in the CXCR4 gene to determine the presence or absence of significant associations with susceptibility to HIV-1
infection. The study consisted of 257 HIV-1–seropositive patients and 113 HIV-1–seronegative controls representing a sub-Saharan African
population belonging to the Xhosa ethnic group of South Africa. The SDF1-3'A SNP was associated with an increased risk for HIV-1 infection (P = 0.0319) whereas no significant association was observed between the occurrence of the SDF1-3'A SNP and increased or decreased plasma levels of CXCL12. Comprehensive mutation analysis of the CXCR4 gene confirmed a high degree of genetic
conservation within the coding region of this ancient population. |
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dc.description.sponsorship |
The authors thank Lehana Breytenbach for sample collection and maintenance of the HIV database;
Heather Money for the coordination of blood specimens from the Western Province Blood Transfusion Service;
all clinicians and nursing staff at the HIV clinics and blood transfusion services of the Western Cape;
and the study participants. |
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dc.format.extent |
11637 bytes |
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dc.format.mimetype |
application/pdf |
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dc.identifier.citation |
Petersen, DC, Glashoff, RH, Shrestha, S, Bergeron, J, Laten, A, Gold, B, Janse van Rensburg, E, Dean, M & Hayes, VM 2005,'Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and conservation of CXCR4 in an African population', Journal of Acquired Immune Deficiency Syndrome, vol. 40, no. 5, pp. 521-526.[http://www.lww.com/product/?1525-4135] |
en |
dc.identifier.issn |
1525-4135 |
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dc.identifier.uri |
http://hdl.handle.net/2263/3169 |
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dc.language.iso |
en |
en |
dc.publisher |
Lippincott Williams and Wilkins |
en |
dc.rights |
Lippincott Williams and Wilkins.
The publisher prohibits open access to the full text of this article |
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dc.subject |
CXC chemokine ligand 12 (CXCL12) |
en |
dc.subject |
CXC chemokine |
en |
dc.subject |
SDF1-3'A single-nucleotide polymorphism |
en |
dc.subject |
HIV-1 infection risk |
en |
dc.subject |
African population |
en |
dc.subject.lcsh |
HIV infections -- Research |
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dc.subject.lcsh |
AIDS (Disease) -- Sub-Saharan Africa |
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dc.title |
Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population |
en |
dc.type |
Article |
en |