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Browsing Research Articles (Pharmacology) by UP Author "Hurrell, Tracey"
Now showing items 1-8 of 8
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Khwitshana, A.K.; Greeff, Oppel Bernhardt Wilhelm; Hurrell, Tracey (Health and Medical Publishing Group, 2014)BACKGROUND. HIV research is a therapeutic area for which well-defined population-specific treatment and prophylaxis guidelines exist. However, there are limited objective, evidence-based data for assessing adherence to ...
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Hurrell, Tracey; Ellero, Andrea Antonio; Masso, Zelie Flavienne; Cromarty, Allan Duncan (Elsevier, 2018-08)Hepatotoxicity remains a major challenge in drug development despite preclinical toxicity screening using hepatocytes of human origin. To overcome some limitations of reproducing the hepatic phenotype, more structurally ...
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Christoforou, Andy; Mulvey, Claire M.; Breckels, Lisa M.; Geladaki, Aikaterini; Hurrell, Tracey; Hayward, Penelope C.; Naake, Thomas; Gatto, Laurent; Viner, Rosa; Arias, Alfonso Martinez; Lilley, Kathryn S. (Nature Publising Group, 2016-01)Knowledge of the subcellular distribution of proteins is vital for understanding cellular mechanisms. Capturing the subcellular proteome in a single experiment has proven challenging, with studies focusing on specific ...
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Hurrell, Tracey; Outhoff, Kim (Dove Medical Press, 2013-06-15)INTRODUCTION: Despite trastuzumab having enhanced selectivity for human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer cells, treatment is hampered by interindividual variation and tumors with high ...
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Hurrell, Tracey; Outhoff, Kim (BioMed Central, 2013-10-11)BACKGROUND: Human epidermal growth factor receptor-2 (Her-2) is over expressed in approximately 25-30% of all primary breast tumors resulting in a distinctive breast cancer subtype associated with a poor prognosis and a ...
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Hurrell, Tracey; Segeritz, Charis-Patricia; Vallier, Ludovic; Lilley, Kathryn S.; Cromarty, Allan Duncan (Oxford University Press, 2018-07)Experimental drugs need to be screened for safety within time constraints. Hepatotoxicity is one concerning contributor to the failure of investigational new drugs and a major rationale for postmarketing withdrawal decisions. ...
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Hurrell, Tracey; Lilley, Kathryn S.; Cromarty, Allan Duncan (Elsevier, 2019-01)Despite the importance of hepatotoxicity testing in the development of new potential pharmaceuticals, standardized methods for preclinical in vitro hepatotoxicity is complicated by the perceived adequacy of approach, ...
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Hurrell, Tracey; Segeritz, Charis-Patricia; Vallier, Ludovic; Lilley, Kathryn S.; Cromarty, Allan Duncan (Nature Publishing Group, 2019-03-01)Numerous in vitro models endeavour to mimic the characteristics of primary human hepatocytes for applications in regenerative medicine and pharmaceutical science. Mature hepatocyte-like cells (HLCs) derived from human ...
Now showing items 1-8 of 8