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Browsing Research Articles (Pharmacology) by Subject "Monoclonal antibody (MAb)"

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A new therapeutic approach for type 1 diabetes : rationale for GNbAC1, an anti‐HERV‐W‐Env monoclonal antibody

Curtin, Francois; Bernard, Corinne; Levet, Sandrine; Perron, Hervé; Porchet, Hervé; Medina, Julie; Malpass, Sam; Lloyd, David; Simpson, Richard (Wiley, 2018-09)

We describe a newly identified therapeutic target for type 1 diabetes (T1D): an envelope protein of endogenous retroviral origin, human endogenous retrovirus W envelope (HERV‐W‐Env). HERV‐W‐Env was found to be detected in ...
A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients

Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; Rasenack, Maria; Matthey, Alain; Du Pasquier, Renaud; Schluep, Myriam; Desmeules, Jules; Lang, Alois B.; Perron, Hervé; Faucard, Raphael; Porchet, Hervé; Hartung, Hans-Peter; Kappos, Ludwig; Lalive, Patrice H. (Sage, 2015-06)

BACKGROUND : GNbAC1 is an immunoglobulin (IgG4) humanised monoclonal antibody against multiple sclerosis-associated retrovirus (MSRV)-Env, a protein of endogenous retroviral origin, expressed in multiple sclerosis (MS) ...
A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients — a twelve month follow-up

Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; Rasenack, Maria; Matthey, Alain; Du Pasquier, Renaud; Schluep, Myriam; Desmeules, Jules; Lang, Alois B.; Perron, Hervé; Faucard, Raphael; Porchet, Hervé; Hartung, Hans-Peter; Kappos, Ludwig; Lalive, Patrice H. (Elsevier, 2015-08)

GNbAC1 is a humanized monoclonal antibody targeting MSRV-Env, an endogenous retroviral protein, which is expressed inmultiple sclerosis (MS) lesions, is pro-inflammatory and inhibits oligodendrocyte precursor cell ...
Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein

Curtin, François; Perron, Hervé; Kromminga, Arno; Porchet, Hervé; Lang, Alois B. (Taylor and Francis, 2015-01)

Monoclonal antibodies (mAbs) play an increasing important role in the therapeutic armamentarium against multiple sclerosis (MS), an inflammatory and degenerative disorder of the central nervous system. Most of the mAbs ...
A randomised placebo-controlled study to investigate GNbAC1 an anti-HERV-W-Env monoclonal antibody in patients with recent onset of type 1 diabetes : rationale and design

Curtin, F.; Bernard, C.; Porchet, Hervé; Levet, S.; Medina, J.; Perron, H.; Oates, S.; Lloyd, D.; Simpson, R. (Wiley, 2018)

AIMS : Human endogenous retroviruses (HERVs) elements, remnants of ancestral viral genomic insertions, are emerging targets in several autoimmune diseases. In type 1 diabetes (T1D) patients, the envelope protein of HERV-W ...

Now showing items 1-5 of 5

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Browsing Research Articles (Pharmacology) by Subject "Monoclonal antibody (MAb)"

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