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Browsing Research Articles (Pharmacology) by Subject "Monoclonal antibody"

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A high-dose pharmacokinetic study of a new IgG4 monoclonal antibody temelimab/GNbAC1 antagonist of an endogenous retroviral protein pHERV-W Env

Porchet, Hervé; Vidal, Virginie; Kornmann, Gabrielle; Malpass, Sam; Curtin, Francois (Elsevier, 2019-09)

PURPOSE : Temelimab/GNbAC1 is a humanized immunoglobulin G4 monoclonal antibody antagonist of the human endogenous retrovirus W envelope protein, which is associated with multiple sclerosis (MS) pathophysiology and possibly ...

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