Browsing Research Articles (Pharmacology) by Subject "HepG2 cells"

Now showing items 1-3 of 3

Characterization and reproducibility of HepG2 hanging drop spheroids toxicology in vitro

Hurrell, Tracey; Ellero, Andrea Antonio; Masso, Zelie Flavienne; Cromarty, Allan Duncan (Elsevier, 2018-08)

Hepatotoxicity remains a major challenge in drug development despite preclinical toxicity screening using hepatocytes of human origin. To overcome some limitations of reproducing the hepatic phenotype, more structurally ...
Proteomic comparison of various hepatic cell cultures for preclinical safety pharmacology

Hurrell, Tracey; Segeritz, Charis-Patricia; Vallier, Ludovic; Lilley, Kathryn S.; Cromarty, Allan Duncan (Oxford University Press, 2018-07)

Experimental drugs need to be screened for safety within time constraints. Hepatotoxicity is one concerning contributor to the failure of investigational new drugs and a major rationale for postmarketing withdrawal decisions. ...
Proteomic responses of HepG2 cell monolayers and 3D spheroids to selected hepatotoxins

Hurrell, Tracey; Lilley, Kathryn S.; Cromarty, Allan Duncan (Elsevier, 2019-01)

Despite the importance of hepatotoxicity testing in the development of new potential pharmaceuticals, standardized methods for preclinical in vitro hepatotoxicity is complicated by the perceived adequacy of approach, ...

Now showing items 1-3 of 3

Search UPSpace