Hurrell, Tracey; Segeritz, Charis-Patricia; Vallier, Ludovic; Lilley, Kathryn S.; Cromarty, Allan Duncan(Oxford University Press, 2018-07)
Experimental drugs need to be screened for safety within time constraints. Hepatotoxicity is one concerning contributor to the failure of investigational new drugs and a major rationale for postmarketing withdrawal decisions. ...
Numerous in vitro models endeavour to mimic the characteristics of primary human hepatocytes
for applications in regenerative medicine and pharmaceutical science. Mature hepatocyte-like cells
(HLCs) derived from human ...
