Browsing Research Articles (Pharmacology) by Title

Browsing Research Articles (Pharmacology) by Title

Sort by: Order: Results:

  • Fatalities involving illicit drug use in Pretoria, South Africa, for the period 2003-2012 
    Liebenberg, Jade; Du Toit-Prinsloo, Lorraine; Steenkamp, Vanessa; Saayman, Gert (Health and Medical Publishing Group, 2016-10)
    Background. Globally, illicit drugs are responsible for many fatalities annually, yet accurate data on the nature and extent of these deaths in South Africa (SA) are lacking. Objectives. To investigate the presence and ...
  • Focus on azithromycin 
    Padayachee, N.; Milne, M; Schellack, Natalie (MedPharm Publications, 2021)
    Azithromycin is a second-generation macrolide that was developed in the early 1980s as a semi-synthetic derivative of erythromycin. This broad-spectrum antibiotic is known for its activity against some Gram-negative organisms ...
  • Gastro-oesophageal reflux - an overview 
    Padayachee, N.; Bangalee, V.; Schellack, Natalie (Medpharm Publications, 2022)
    Gastro-oesophageal reflux disease (GORD) presents with patients experiencing discomfort due to acid-containing stomach contents persistently being refluxed into the oesophagus. This condition can lead to serious complications ...
  • Grommets 
    Outhoff, Kim (MedPharm Publications, 2015)
    Children younger than 7 years are at increased risk of otitis media because of their immature immune systems and poorly functioning eustachian tubes that normally ventilate the middle ear space and equalize pressure with ...
  • Grommets - an update on common indications for tympanostomy tube placement 
    Outhoff, Kim (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2017)
    Children younger than 7 years are at increased risk of otitis media because of their immature immune systems and poorly functioning eustachian tubes that normally ventilate the middle ear space and equalize pressure with ...
  • Help-seeking by substance dependants presenting to healthcare professionals in the Free State Province 
    Van Zyl, P.M.; Gagiono, C.A.; Mollentze, W.F.; Snyman, J.S.; Joubert, G. (Health and Medical Publishing Group, 2012-08)
    INTRODUCTION: Current data regarding treatment needs in South Africa for substance dependence are based on admissions to specialised treatment centres. The data therefore do not include patients presenting to independent ...
  • Herbal remedies affecting coagulation : a review 
    Cordier, Werner; Steenkamp, Vanessa (Routledge, 2012-04)
    CONTEXT: Herbal remedies are used to treat a large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly ...
  • A high-dose pharmacokinetic study of a new IgG4 monoclonal antibody temelimab/GNbAC1 antagonist of an endogenous retroviral protein pHERV-W Env 
    Porchet, Hervé; Vidal, Virginie; Kornmann, Gabrielle; Malpass, Sam; Curtin, Francois (Elsevier, 2019-09)
    PURPOSE : Temelimab/GNbAC1 is a humanized immunoglobulin G4 monoclonal antibody antagonist of the human endogenous retrovirus W envelope protein, which is associated with multiple sclerosis (MS) pathophysiology and possibly ...
  • Highlights of basic and clinical pharmacology from Africa 
    Steenkamp, Vanessa (Wiley, 2023-04)
    The special themed issue; ‘Highlights of Basic and Clinical Pharmacology from Africa’ is a compilation of contributions from both basic and clinical research from the African continent. The publications included in this ...
  • Human epidermal growth factor receptor 2-positive breast cancer : which cytotoxic agent best complements trastuzumab's efficacy in vitro? 
    Hurrell, Tracey; Outhoff, Kim (Dove Medical Press, 2013-06-15)
    INTRODUCTION: Despite trastuzumab having enhanced selectivity for human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer cells, treatment is hampered by interindividual variation and tumors with high ...
  • Hybrid compounds containing carvacrol scaffold : in vitro antibacterial and cytotoxicity evaluation 
    Mbese, Zintle; Nell, Margo Judith; Fonkui, Youmbi Thierry; Ndinteh, Derek Tantoh; Steenkamp, Vanessa; Aderibigbe, Blessing Atim (Bentham Science Publishers, 2022-03)
    Please read abstract in the article.
  • Hypercholesterolaemia : from inauspicious to appropriate to detrimental 
    Marais, Andre (MedPharm Publications, 2016)
    Hypercholesterolaemia is a chronic disease that affects up to 53% of the global population.1 Lifestyle modification and early diagnosis plays an important role in the management of this condition. Various cholesterol ...
  • Hypertension 
    Schellack, Natalie; Padayachee, N. (Medpharm Publications, 2022)
    This article provides an overview of the changes that have taken place in the diagnosis and management of hypertension over the past decade. Hypertension remains a widespread condition seen in South Africa. The approach ...
  • Hypertension : back to basics 
    Ker, James A.; Outhoff, Kim (Medpharm Publications, 2023)
    This article outlines the principles of blood pressure, including normal and dysfunctional physiology, mathematical equations of pressure, definitions of hypertension and diagnosis, and hence the rationale for and mechanisms ...
  • Hypertension in goldminers 
    Maepe, L.M.; Outhoff, Kim (Health and Medical Publishing Group, 2012-01)
    BACKGROUND: Reliable information about the prevalence of hypertension, which is a major contributor to cardiovascular disease in general and to coronary heart disease in particular, in different geographical regions is ...
  • Hyperuricaemia and gout : a review 
    Kopke, Amy; Greeff, Oppel Bernhardt Wilhelm (OpenJournals Publishing, 2010-03)
    Gout is a painful, inflammatory disease that affects more men than women. The incidence of gout has increased substantially over the past few decades, as evidenced by information from the Rochester project. Some of the ...
  • Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy : a pilot study 
    Chaudhry, Mamoonah; Alessandrini, Marco; Rademan, Jacobus; Dodgen, Tyren Mark; Steffens, Francois E.; Van Zyl, Danie G.; Gaedigk, Andrea; Pepper, Michael Sean (Future Medicine, 2017-03)
    AIM : Therapy with low-dose amitriptyline is commonly used to treat painful diabetic peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable CYP2D6-mediated drug metabolism and side effects ...
  • Important pharmacogenomic aspects in the management of HIV/AIDS 
    Marais, Andre; Osuch, Elzbieta; Steenkamp, Vanessa; Ledwaba, L. (AOSIS Open Journals, 2019)
    In managing HIV/AIDS with highly active antiretroviral agents, the historical therapeutic aim remains to maintain the plasma concentrations at a level above the half maximal inhibitory concentration (IC50) required for ...
  • In vitro antimicrobial activity of medicinal plants against oral Candida albicans isolates 
    Van Wyk, Candice; Botha, Francien Susanna; Steenkamp, Vanessa (Global Science Books, 2009-12)
    Please read abstract in article.
  • The in vitro antitumour activity of novel, mitochondrial-interactive, gold-based lipophilic cations 
    Mahepal, Sherika; Bowen, Richard; Mamo, Messai Adenew; Layh, Marcus; Jansen van Rensburg, Constance Elizabeth (Hindawi, 2008)
    Please refer to abstract in article