Browsing Research Articles (Immunology) by UP Author "Mellet, Juanita"

Browsing Research Articles (Immunology) by UP Author "Mellet, Juanita"

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  • Consequences of HIV infection in the bone marrow niche 
    Herd, Candice; Mellet, Juanita; Mashingaidze, Nester; Durandt, Chrisna; Pepper, Michael Sean (Frontiers Media, 2023-07-11)
    Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular ...
  • Constituting a public umbilical cord blood bank in South Africa 
    Mellet, Juanita; Alessandrini, Marco; Steel, Helen C.; Pepper, Michael Sean (Nature Publishing Group, 2015-04)
    No abstract available
  • Coronavirus host genetics South Africa (COHG-SA) database—a variant database for gene regions associated with SARS-CoV-2 outcomes 
    Barmania, Fatima; Mellet, Juanita; Ryder, Megan A.; Ford, Graeme R.; Herd, Candice L.; Tamuhla, Tsaone; Hendricks, Candice Laverne; Giles, Rachel; Kalua, Thumbiko; Joubert, Fourie; Tiffin, Nicki; Pepper, Michael Sean (Springer nature, 2022-08)
    The SARS-CoV-2 virus is responsible for the COVID-19 global public health emergency, and the disease it causes is highly variable in its clinical presentation. Clinical phenotypes are heterogeneous both in terms of ...
  • A COVID-19 vaccine : big strides come with big challenges 
    Mellet, Juanita; Pepper, Michael Sean (MDPI, 2021-01)
    As of 8 January 2021, there were 86,749,940 confirmed coronavirus disease 2019 (COVID19) cases and 1,890,342 COVID-19-related deaths worldwide, as reported by the World Health Organization (WHO). In order to address the ...
  • Haematopoietic stem-cell transplantation in an HIV endemic area : time to consider donors exposed to or living with HIV 
    Hendricks, Candice Laverne; Mellet, Juanita; Durandt, Chrisna; Brittain, David; Pepper, Michael Sean (Elsevier, 2023-11)
    South Africa has more than 8 million people living with HIV. However, the number of patients undergoing haematopoietic stem-cell transplantation (HSCT) in South Africa is far below the target number. Donor numbers are ...
  • Heterogeneity of cell therapy products 
    Wolmarans, Elize; Mellet, Juanita; Ambele, Melvin Anyasi; Durandt, Chrisna; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    Cellular therapy has become a billion-dollar industry and is set to become one of the therapeutic pillars of healthcare in the 21st century. Adult stem cells, which include haematopoietic stem and progenitor cells (HSPCs) ...
  • HIV and haematopoiesis 
    Durandt, Chrisna; Potgieter, J.C.; Mellet, Juanita; Herd, Candice Lee; Khoosal, R.; Nel, Jan Gert; Rossouw, Theresa M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-09)
    Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and ...
  • HLA typing : conventional techniques v. next-generation sequencing 
    Mellet, Juanita; Gray, C.M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2016-01)
    BACKGROUND. The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need ...
  • Human leukocyte antigen (HLA) diversity and clinical applications in South Africa 
    Mellet, Juanita; Tshabalala, Mqondisi; Agbedare, O.; Meyer, Pieter Willem Adriaan; Gray, C.M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-09)
    The major histocompatibility complex, known as the human leukocyte antigen (HLA) complex in humans, forms an integral component of adaptive T cell immunity by presenting self and non-self peptides to the T cell receptor, ...
  • Human leukocyte antigen diversity : a Southern African perspective 
    Tshabalala, Mqondisi; Mellet, Juanita; Pepper, Michael Sean (Hindawi Publishing, 2015)
    Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations, there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA ...
  • The NESHIE and CP Genetics Resource (NCGR): A database of genes and variants reported in neonatal encephalopathy with suspected hypoxic ischemic encephalopathy (NESHIE) and consequential cerebral palsy (CP) 
    Holborn, Megan A.; Ford, Graeme R.; Turner, Sarah; Mellet, Juanita; Van Rensburg, Jeanne; Joubert, Fourie; Pepper, Michael Sean (Elsevier, 2022-11)
    Neonatal encephalopathy (NE) with suspected hypoxic ischaemic encephalopathy (HIE) (NESHIE) is a complex syndrome occurring in newborns, characterised by altered neurological function. It has been suggested that genetic ...
  • Open access and its potential impact on public health – a South African perspective 
    Strydom, Adele; Mellet, Juanita; Van Rensburg, Jeanne; Viljoen, Ignatius M.; Athanasiadis, Anastasios; Pepper, Michael Sean (Frontiers Media, 2022-12)
    Traditionally, access to research information has been restricted through journal subscriptions. This means that research entities and individuals who were unable to afford subscription costs did not have access to journal ...
  • Perspectives on establishing a public cord blood inventory in South Africa 
    Viljoen, Ignatius M.; Hendricks, Candice Laverne; Mellet, Juanita; Pepper, Michael Sean (Elsevier, 2021-06)
    The South African population is highly diverse, both ethnically and genetically. This diversity is particularly true for the African ancestry and various mixed ancestry population groups. These groups are under-represented ...
  • SARS-CoV-2 variants, vaccines, and host immunity 
    Mistry, Priyal; Barmania, Fatima; Mellet, Juanita; Peta, Kimberly Thando; Strydom, Adele; Viljoen, Ignatius M.; James, William; Gordon, Siamon; Pepper, Michael Sean (Frontiers Media SA, 2022-01-03)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus that emerged at the end of 2019 in the Hubei province of China. SARS-CoV-2 causes coronavirus disease 2019 (COVID-19) and was declared ...
  • Side population : its use in the study of cellular heterogeneity and as a potential enrichment tool for rare cell populations 
    Wolmarans, Elize; Nel, Sulette; Durandt, Chrisna; Mellet, Juanita; Pepper, Michael Sean (Hindawi Publishing Corporation, 2018-12-06)
    There is still much to learn about the cells used for cell- and gene-based therapies in the clinical setting. Stem cells are found in virtually all tissues in the human body. As a result, cells isolated from these tissues ...