Browsing Research Articles (Immunology) by UP Author "Pepper, Michael Sean"

Browsing Research Articles (Immunology) by UP Author "Pepper, Michael Sean"

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  • Constituting a public umbilical cord blood bank in South Africa 
    Mellet, Juanita; Alessandrini, Marco; Steel, Helen C.; Pepper, Michael Sean (Nature Publishing Group, 2015-04)
    No abstract available
  • Contact tracing during the COVID-19 pandemic : protection of personal information in South Africa 
    Viljoen, Ignatius M.; Castelyn, Camille De Villebois; Pope, A.; Botes, M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2020-07)
    Containing the COVID-19 pandemic necessitates the use of personal information without the consent of the person. The protection of personal information is fundamental to the rights that ensure an open and democratic ...
  • Contrasting views on the role of mesenchymal stromal/stem cells in tumour growth : a systematic review of experimental design 
    Oloyo, Ahmed Kolade; Ambele, Melvin Anyasi; Pepper, Michael Sean (Springer, 2017-11)
    The effect of mesenchymal stromal/stem cells (MSCs) on tumour growth remains controversial. Experimental evidence supports both an inhibitory and a stimulatory effect. We have assessed factors responsible for the contrasting ...
  • The correlation between the health-related fitness of healthy participants measured at home as opposed to fitness measured by sport scientists in a laboratory 
    Grant, C.C. (Catharina Cornelia); Janse van Rensburg, Dina Christina; Pepper, Michael Sean; Du Toit, Peet J.; Wood, Paola Silvia; Ker, James A.; Kruger, P.E. (Pieter Ernst); Grobbelaar, C.W. (Craig); Nolte, Kim; Fletcher, F.; Grant, T.C. (Thelani) (Medpharm Publications, 2014)
    BACKGROUND : Fitness is defined in the health context as a state of good health or physical condition, primarily as a result of exercise and proper nutrition. Conventional methods of measuring fitness are expensive, time ...
  • The COVID-19 treatment landscape : a South African perspective on a race against time 
    Hendricks, Candice Laverne; Herd, Candice Lee; Nel, Marcel; Tintinger, Gregory Ronald; Pepper, Michael Sean (Frontiers Media, 2021-02-19)
    The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which ...
  • CRISPR-Cas : revolutionising genome engineering 
    Nicholson, S.A.; Pepper, Michael Sean (Health and Medical Publishing Group, 2016-09)
    The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome ...
  • Cystic fibrosis in South Africa : a changing diagnostic paradigm 
    Van Rensburg, J.; Alessandrini, Marco; Stewart, Cheryl; Pepper, Michael Sean (Health and Medical Publishing Group, 2018-08)
    Cystic fibrosis (CF), one of the most commonly observed and diagnosed fatal monogenic disorders globally, was initially thought to affect individuals of Caucasian/European descent almost exclusively. It is increasingly ...
  • Cystic fibrosis in the African diaspora 
    Stewart, Cheryl; Pepper, Michael Sean (American Thoracic Society, 2017-01)
    Identifying mutations that cause cystic fibrosis (CF) is important for making an early, unambiguous diagnosis, which, in turn, is linked to better health and a greater life expectancy. In patients of African descent, a ...
  • Cystic fibrosis on the African continent 
    Stewart, Cheryl; Pepper, Michael Sean (Nature Publishing Group, 2016-07)
    Cystic fibrosis (CF; OMIM 219700) is a life-shortening and costly autosomal recessive disease that has been most extensively studied in individuals of Caucasian descent. There is ample evidence, however, that it also affects ...
  • The deep genome project 
    Lloyd, K.C. Kent; Adams, David J.; Baynam, Gareth; Beaudet, Arthur L.; Bosch, Fatima; Boycott, Kym M.; Braun, Robert E.; Caulfield, Mark; Cohn, Ronald; Dickinson, Mary E.; Dobbie, Michael S.; Flenniken, Ann M.; Flicek, Paul; Galande, Sanjeev; Gao, Xiang; Grobler, Anne; Heaney, Jason D.; Herault, Yann; Hrabe de Angelis, Martin; Lupski, James R.; Lyonnet, Stanislas; Mallon, Ann-Marie; Mammano, Fabio; MacRae, Calum A.; McInnes, Roderick; McKerlie, Colin; Meehan, Terrence F.; Murray, Stephen A.; Nutter, Lauryl M.J.; Obata, Yuichi; Parkinson, Helen; Pepper, Michael Sean; Sedlacek, Radislav; Seong, Je Kyung; Shiroishi, Toshihiko; Smedley, Damian; Tocchini-Valentini, Glauco; Valle, David; Leo Wang, Chi-Kuang; Wells, Sara; White, Jacqueline; Wurst, Wolfgang; Xu, Ying; Brown, Steve D.M. (BioMed Central, 2020-02-03)
    In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, ...
  • Deoxyribonucleic acid damage and repair : capitalizing on our understanding of the mechanisms of maintaining genomic integrity for therapeutic purposes 
    Helena, Jolene Michelle; Joubert, Anna Margaretha; Grobbelaar, Simone; Nolte, Elsie Magdalena; Nel, Marcel; Pepper, Michael Sean; Coetzee, Magdalena; Mercier, Anne Elisabeth (MDPI Publishing, 2018-04-11)
    Deoxyribonucleic acid (DNA) is the self-replicating hereditary material that provides a blueprint which, in collaboration with environmental influences, produces a structural and functional phenotype. As DNA coordinates ...
  • An early infant HIV risk score for targeted HIV testing at birth 
    Du Plessis, Nicolette Marie; Muller, Chris J.B.; Avenant, Theunis Johannes; Pepper, Michael Sean; Goga, Ameena Ebrahim (American Academy of Pediatrics, 2019-06)
    BACKGROUND : Early HIV testing is needed for treatment success in young infants, but universal testing is expensive. In this study, we examined the feasibility of early infant HIV risk scores for targeted polymerase chain ...
  • Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model 
    Peta, Kimberly; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2023-10)
    The prevalence of breast cancer (BC) continues to increase and is the leading cause of cancer deaths in many countries. Numerous in vitro and in vivo studies have demonstrated that 2‐methoxyestradiol (2‐ME) has ...
  • The effect of early rounds of ex vivo expansion and cryopreservation on the adipogenic differentiation capacity of adipose-derived stromal/stem cells 
    Durandt, Chrisna; Dessels, Carla; Da Silva, C.; Murdoch, Candice; Pepper, Michael Sean (Nature Publishing Group, 2019-11-04)
    Multipotent adipose-derived stromal/stem cells (ASCs) are candidates for use in cellular therapies for the treatment of a variety of conditions/diseases. Ex vivo expansion of freshly isolated ASCs may be necessary prior ...
  • Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis 
    Naidoo, Anushka; Ramsuran, Veron; Chirehwa, Maxwell; Denti, Paolo; McIlleron, Helen; Naidoo, Kogieleum; Yende-Zuma, Nonhlanhla; Singh, Ravesh; Ngcapu, Sinaye; Chaudhry, Mamoonah; Pepper, Michael Sean; Padayatchi, Nesri (Future Medicine, 2018)
    AIM : We assessed the effect of genetic variability in UGT1A and ABCB1 genes on moxifloxacin pharmacokinetics. METHODS : Genotypes for selected UGT1A and ABCB1 SNPs were determined using a TaqMan® Genotyping OpenArray™ and ...
  • The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro 
    Dessels, Carla; Ambele, Melvin Anyasi; Pepper, Michael Sean (BMC, 2019-08)
    BACKGROUND: For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro ...
  • Enactment of chapter 8 of the National Health Act and regulations thereto 
    Pepper, Michael Sean (South African Journal of Bioethics and Law, 2012-06)
    No abstract available.
  • Establishing a public umbilical cord blood stem cell bank for South Africa : an enquiry into public acceptability 
    Meissner-Roloff, Madelein; Pepper, Michael Sean (Springer, 2013-12)
    South Africa (SA) faces a large unmet need for bone marrow (BM) transplantation, which could be alleviated in part by establishing a public umbilical cord blood stem cell bank (UCB SCB). Umbilical cord blood is an increasingly ...
  • Establishment and equilibrium levels of deleterious mutations in large populations 
    Viljoen, Johan W.; De Villiers, J Pieter.; Van Zyl, Augustinus J.; Mezzavilla, Massimo.; Pepper, Michael Sean (Nature Research, 2019-07)
    Analytical and statistical stochastic approaches are used to model the dispersion of monogenic variants through large populations. These approaches are used to quantify the magnitude of the selective advantage of a monogenic ...
  • Ethical considerations in the application of cell and gene therapies in children 
    Pepper, Michael Sean; Pope, A.; Kling, S.; Alessandrini, M.; Van Staden, W.; Green, Robin J. (Health and Medical Publishing Group, 2018-12)
    Rapidly evolving fields such as cell and gene therapies that involve state-of-the-art technology hold out possibilities that may be ahead of what ethics, guidelines and the law have considered. This results in a regulatory ...