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Browsing Research Articles (Physiology) by UP Author "Coetzee, Magdalena"
Now showing items 1-20 of 24
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Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (MDPI Publishing, 2019-04-11)Osteoclasts are the sole bone resorbing cell in the body and their over activity is key in the development of osteoporosis. Osteoclastogenesis is mediated by receptor activator of nuclear factor B ligand (RANKL) signalling ...
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Kasonga, Abe E.; Deepak, Vishwa; Kruger, Marlena C.; Coetzee, Magdalena (Public Library of Science, 2015-04-13)An unbalanced diet can have adverse effects on health. Long chain polyunsaturated fatty acids (LCPUFAs) have been the focus of research owing to their necessity of inclusion in a healthy diet. However, the effects of ...
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Sagar, Travers; Kasonga, Abe E.; Baschant, Ulrike; Rauner, Martina; Moosa, Shaakirah; Marais, Sumari; Kruger, Marlena C.; Coetzee, Magdalena (Elsevier, 2020-01)Bone remodelling in a healthy body is in constant balance, maintaining an adaptive and robust skeletal system. In osteoporosis this balance is disrupted with the rates of osteoclastic bone resorption exceeding osteoblastic bone ...
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Deepak, Vishwa; Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (Pharmaceutical Society of Japan, 2016-07)Bone is a dynamic tissue that undergoes continuous remodeling coupled with the action of osteoblasts and osteoclasts. Osteoclast activity is elevated during osteoporosis and periodontitis resulting in excessive loss of ...
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Visagie, Amcois; Kasonga, Abe E.; Deepak, Vishwa; Moosa, Shaakirah; Marais, Sumari; Kruger, Marlena C.; Coetzee, Magdalena (MDPI Publishing, 2015-10)Honeybush tea, a sweet tasting caffeine-free tea that is indigenous to South Africa, is rich in bioactive compounds that may have beneficial health effects. Bone remodeling is a physiological process that involves the ...
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Helena, Jolene Michelle; Joubert, Anna Margaretha; Grobbelaar, Simone; Nolte, Elsie Magdalena; Nel, Marcel; Pepper, Michael Sean; Coetzee, Magdalena; Mercier, Anne Elisabeth (MDPI Publishing, 2018-04-11)Deoxyribonucleic acid (DNA) is the self-replicating hereditary material that provides a blueprint which, in collaboration with environmental influences, produces a structural and functional phenotype. As DNA coordinates ...
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Kruger, Marlena C.; Tousen, Y.; Katsumata, S.; Tadaishi, M.; Kasonga, Abe E.; Deepak, Vishwa; Coetzee, Magdalena; Ishimi, Y. (Center for Academic Publications Japan, 2015-05)New Zealand is a rich source of food components that may have bioactivity on bone. Docosahexaenoic acid (DHA) from fish oil has been shown to maintain bone in ovariectomised (OVX) rats. Kiwifruit, a source of fibre and ...
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Boeyens, Jan Christoffel Antonie; Deepak, Vishwa; Chua, Wei-Hang; Kruger, Marlena C.; Joubert, Annie M.; Coetzee, Magdalena (Molecular Diversity Preservation International, 2014-07)Polyunsaturated fatty acids (PUFAs) have been reported to have an anabolic effect on bone in vivo, but comparative studies to identify inhibitors of osteoclast formation amongst ω3- and ω6-PUFAs are still lacking. Here we ...
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Rantlha, Mpho; Sagar, Travers; Kruger, Marlena C.; Coetzee, Magdalena; Deepak, Vishwa (Springer, 2017-01)Bone undergoes continuous remodeling by a coupled action between osteoblasts and osteoclasts. During osteoporosis, osteoclast activity is often elevated leading to increased bone destruction. Hence, osteoclasts are deemed ...
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Sagar, Travers; Rantlha, Mpho; Kruger, Marlena C.; Coetzee, Magdalena; Deepak, Vishwa (Springer, 2016-10)Elevated bone loss induced by osteoclasts is a critical and most commonly observed pathological complication during osteolytic diseases such as osteoporosis. Hence, attenuation of osteoclast formation or function is a ...
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Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (Elsevier, 2019-03)Bone is a dynamic tissue that is constantly remodelled by bone resorbing osteoclasts and bone forming osteoblasts, respectively. A breakdown in the remodelling process underlies several bone diseases such as osteoporosis. ...
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Deepak, Vishwa; Kruger, Marlena C.; Coetzee, Magdalena (Springer, 2017-01)Osteoporotic patients have lower bone mass due to increased bone resorption by osteoclasts. The aim of this study was to investigate the cytotoxic and antiosteoclastogenic effects of geraniol, a natural monoterpene on ...
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Haag, Marianne; Coetzee, Magdalena (Suid-Afrikaanse Akademie vir Wetenskap en Kuns, 2006-06)Vetsure speel 'n uiters belangrike rol in die fisiologie van die mens. Afgesien daarvan dat vetsure in gestoorde trigliseriede gebruik word vir energieverskaffing, word vetsure vanaf dieetlipiede in plasma vervoer en ingebou ...
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Laing, M.J.; Boeyens, Jan Christoffel Antonie; Coetzee, Magdalena (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)This study investigated the effects of arachidonic acid and prostaglandin E2 on osteoclast formation and bone resorption in RAW 264.7 murine pre-osteoclasts. Data obtained suggests an inhibitory effect of these compounds on ...
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Kasonga, Abe E.; Boeyens, Jan Christoffel Antonie; Coetzee, Magdalena (AOSIS Open Journals, 2012)This study investigated the effects of eicosapentanoic acid and prostaglandin E3 on osteoclast formation and bone resorption in RAW 264.7 murine pre-osteoclasts. Data obtained suggests an inhibitory effect of these compounds ...
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Boeyens, J.E.A.; Ehua, W.H.; Kruger, M.E.; Joubert, Annie M.; Coetzee, Magdalena (AOSIS Open Journals, 2013)This study investigated effects of polyunsaturated fatty acids on osteoclast formation and bone resorption in RAW 264.7 murine pre-osteoclasts. Data obtained suggests an inhibitory effect of the fatty acids on these parameters.
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Deepak, Vishwa; Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (Informa Healthcare, 2015-06)Bone loss diseases are often associated with increased receptor activator of NF-κB ligand (RANKL)-induced osteoclast formation. Compounds that can attenuate RANKL-mediated osteoclast formation are of great biomedical ...
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Helena, Jolene Michelle; Joubert, Anna Margaretha; Mabeta, Peaceful Lucy; Coetzee, Magdalena; Lakier, Roy; Mercier, Anne Elisabeth (MDPI, 2021-08-17)2-Ethyl-3-O-sulfamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is an in silico-designed estradiol analogue which has improved the parent compound’s efficacy in anti-cancer studies. In this proofof- concept study, the potential ...
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Kruger, Marlena C.; Coetzee, Magdalena; Haag, Marianne; Weiler, H. (2010-10)Evidence presented over the past 20 years has shown that long-chain polyunsaturated fatty acids (LCPUFAs), especially the n-3 fatty acids such as eicospentaenoic acid (EPA) and docosahexaenoic acid (DHA) are beneficial ...
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Van Heerden, Bernadette; Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (MDPI Publishing, 2017-04-28)Osteoclasts are large,multinucleated cells that are responsible for the breakdown or resorption of bone during bone remodelling. Studies have shown that certain fatty acids (FAs) can increase bone formation, reduce bone ...
Now showing items 1-20 of 24