• Deoxyribonucleic acid damage and repair : capitalizing on our understanding of the mechanisms of maintaining genomic integrity for therapeutic purposes 

  Helena, Jolene Michelle; Joubert, Anna Margaretha; Grobbelaar, Simone; Nolte, Elsie M.; Nel, Marcel; Pepper, Michael Sean; Coetzee, Magdalena; Mercier, Anne Elisabeth (MDPI Publishing, 2018-04-11)

  Deoxyribonucleic acid (DNA) is the self-replicating hereditary material that provides a blueprint which, in collaboration with environmental influences, produces a structural and functional phenotype. As DNA coordinates ...
• Synergistic in-vitro effects of combining an antiglycolytic, 3-bromopyruvate, and a bromodomain-4 inhibitor on U937 myeloid leukemia cells 

  Kapp, Nicolette; Stander, Xiao Xing; Stander, Barend Andre (Lippincott, Williams & Wilkins, 2018-06)

  This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute ...
• A novel 2-methoxyestradiol analogue is responsible for vesicle disruption and lysosome aggregation in breast cancer cells 

  Nkandeu, D.S. (Danielle Sandra); Van den Bout, Jan Iman; Cronjé, Marianne J.; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Joubert, Anna Margaretha (Karger Publishers, 2018)

  BACKGROUND : 2-Methoxyestradiol (2ME2) is an endogenous metabolite of 17-β-estradiol with anti-proliferative and anti-angiogenic properties. Due to 2ME2’s rapid metabolism and low oral bioavailability in in vivo settings, ...
• Continuous kisspeptin restores luteinizing hormone pulsatility following cessation by a neurokinin B antagonist in female sheep 

  Clarke, Iain J.; Li, Qun; Henry, Belinda A.; Millar, Robert P. (Oxford University Press, 2018-02)

  Pulsatile secretion of the gonadotropin-releasing hormone (GnRH) drives pulsatile secretion of the luteinizing hormone (LH), with evidence that this depends on kisspeptin (Kiss) input to GnRH neurons. Kiss administration ...
• The inflammatory effects of TNF-α and complement component 3 on coagulation 

  Page, Martin J.; Bester, Janette; Pretorius, Etheresia (Nature Publishing Group, 2018-01-29)

  Tissue necrosis factor-α (TNF-α) and complement component 3 (C3) are two well-known proinflammatory molecules. When TNF-α is upregulated, it contributes to changes in coagulation and causes C3 induction. They both interact ...
• Eryptosis : an erythrocyte’s suicidal type of cell death 

  Repsold, Lisa; Joubert, Annie M. (Hindawi Publishing Corporation, 2018-01-03)

  Erythrocytes play an important role in oxygen and carbon dioxide transport. Although erythrocytes possess no nucleus or mitochondria, they fulfil severalmetabolic activities namely, the Embden-Meyerhof pathway, as well ...
• Measuring physical activity in South African grade 2 and 3 learners : a self-report questionnaire versus pedometer testing 

  Malan, Guiliame F.; Nolte, Kim (Southern African Alliance for Sport Science, Physical Education and Recreation, 2017)

  The prevalence of childhood obesity is increasing in South Africa and can be linked to decreased physical activity (PA). It is important to be able to accurately measure children’s PA levels as part of a holistic strategy ...
• The validity of arterial measurements in a South African embalmed body population 

  Schoeman, Marelize; Van Schoor, Albert-Neels; Suleman, Farhana Ebrahim; Louw, Liebie; Du Toit, Peet J. (Springer, 2018-01)

  INTRODUCTION : Knowledge of the normal arterial diameter at a given anatomical point is the first step toward quantifying the severity of cardiovascular diseases. According to several studies, parameters such as weight, ...
• Effective long-term solution to therapeutic remission in inflammatory bowel disease : role of azathioprine 

  Adam, Lyla; Phulukdaree, Alisa; Soma, Prashilla (Elsevier, 2018-04)

  Azathioprine (AZA) is a well-known immunosuppressant used for many years for its ability to ensure long term disease remission in inflammatory bowel diseases (IBD) at an affordable cost to the public. However, the side ...
• Characterizing pathology in erythrocytes using morphological and biophysical membrane properties : relation to impaired hemorheology and cardiovascular function in rheumatoid arthritis 

  Olumuyiwa-Akeredolu, Oore-ofe O.; Soma, Prashilla; Buys, A.V. (Antonia Vergina); Debusho, Legesse Kassa; Pretorius, Etheresia (Elsevier, 2017-12)

  The inflammatory burden of the complex rheumatoid arthritis (RA) disease affects several organ-systems, including rheological properties of blood and its formed elements. Red blood cells (RBCs) are constantly exposed to ...
• Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability 

  Pretorius, Etheresia; Akeredolu, Oore-Ofe; Soma, Prashilla; Kell, Douglas B. (Sage, 2017-02)

  We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This ...
• Acute megakaryoblastic leukaemia: light microscopy and scanning electron microscopy of blast cells 

  Masingi, Ntsakisi I.; Laher, Zaheer; Pretorius, Etheresia (Wiley, 2017-03)

  A 60-year-old human immunodeficiency virus-positive woman presented with splenomegaly.
• An overview of the role of platelets in angiogenesis, apoptosis and autophagy in chronic myeloid leukaemia 

  Repsold, Lisa; Pool, Roger; Karodia, M.; Tintinger, Gregory Ronald; Joubert, Annie M. (BioMed Central, 2017-10-10)

  Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related ...
• Ultrastructural, confocal and viscoelastic characteristics of whole blood and plasma after exposure to cadmium and chromium alone and in combination : an ex vivo study 

  Venter, Chantelle; Oberholzer, Hester Magdalena; Bester, Janette; Van Rooy, Mia-Jeanne; Bester, Megan Jean (Karger Publishers Open Access, 2017)

  BACKGROUND/AIMS : Heavy metal pollution is increasing in the environment, contaminating water, food and air supplies. This can be linked to many anthropogenic activities. Heavy metals are absorbed through the skin, ...
• The role of Sibutramine in the treatment of obesity and a hypothesis on its possible psychological effects 

  Oberholzer, Hester Magdalena; Pretorius, Etheresia (MATTIOLI 1885, 2012)

  Sibutramine is known to be effective in the treatment of obesity and is used worldwide by millions. It acts on the central nervous system by inhibiting the neuronal reuptake of serotonin and noradrenaline; there by also ...
• Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities 

  Pretorius, Etheresia; Mbotwe, Sthembile; Kell, Douglas B. (Nature Publishing Group, 2017-08-29)

  Type 2 diabetes (T2D) has many cardiovascular complications, including a thrombotic propensity. Many such chronic, inflammatory diseases are accompanied (and may be exacerbated, and possibly even largely caused) by ...
• Effects of clomiphene citrate on the expression of kisspeptin dynorphin A and neurokinin B in female Sprague-Dawley rats 

  Fourie, Christle (University of Pretoria, 2017)

  Clomiphene citrate (CC) is the leading treatment for women with anovulatory infertility. The precise mechanism of action of the drug on the hypothalamic-pituitary-gonadal (HPG) axis has yet to be determined. Neurons ...
• The effects of physiological concentrations of 17ß-Estradiol and Progesterone on fibrin network ultrastructure 

  Visagie, Amcois (University of Pretoria, 2017)

  17β-Estradiol (E2) and progesterone (P4) have various important functions but the effect of these endogenous hormone concentrations on fibrin network formation has not been established. It is essential to understand natural ...
• Inflammatory markers and ultrastructure of the coagulation profile in diabetes mellitus 

  Soma, Prashilla (University of Pretoria, 2017)

  Diabetes mellitus has emerged as a major public health problem with pandemic growth as the International Diabetes Federation estimates that there were 415 million diabetics in 2015 with that number reaching 642 million ...
• Palmitoleic acid inhibits RANKL-induced osteoclastogenesis and bone resorption by suppressing NF- B and MAPK signalling pathways 

  Van Heerden, Bernadette; Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (MDPI Publishing, 2017-04-28)

  Osteoclasts are large,multinucleated cells that are responsible for the breakdown or resorption of bone during bone remodelling. Studies have shown that certain fatty acids (FAs) can increase bone formation, reduce bone ...

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