Clarke, Iain J.; Li, Qun; Henry, Belinda A.; Millar, Robert P.(Oxford University Press, 2018-02)
Pulsatile secretion of the gonadotropin-releasing hormone (GnRH) drives pulsatile secretion of the luteinizing hormone (LH), with evidence that this depends on kisspeptin (Kiss) input to GnRH neurons. Kiss administration ...
Page, Martin J.; Bester, Janette; Pretorius, Etheresia(Nature Publishing Group, 2018-01-29)
Tissue necrosis factor-α (TNF-α) and complement component 3 (C3) are two well-known proinflammatory
molecules. When TNF-α is upregulated, it contributes to changes in coagulation and
causes C3 induction. They both interact ...
Erythrocytes play an important role in oxygen and carbon dioxide transport. Although erythrocytes possess no nucleus or
mitochondria, they fulfil severalmetabolic activities namely, the Embden-Meyerhof pathway, as well ...
Malan, Guiliame F.; Nolte, Kim(Southern African Alliance for Sport Science, Physical Education and Recreation, 2017)
The prevalence of childhood obesity is increasing in South Africa and can be linked to decreased physical activity (PA). It is important to be able to accurately measure children’s PA levels as part of a holistic strategy ...
Schoeman, Marelize; Van Schoor, Albert-Neels; Suleman, Farhana Ebrahim; Louw, Liebie; Du Toit, Peet J.(Springer, 2018-01)
INTRODUCTION : Knowledge of the normal arterial diameter at a given anatomical point is the first step toward quantifying the severity of cardiovascular diseases. According to several studies, parameters such as weight, ...
Azathioprine (AZA) is a well-known immunosuppressant used for many years for its ability to ensure long term disease remission in inflammatory bowel diseases (IBD) at an affordable cost to the public. However, the side ...
The inflammatory burden of the complex rheumatoid arthritis (RA) disease affects several organ-systems, including rheological properties of blood and its formed elements. Red blood cells (RBCs) are constantly exposed to ...
Pretorius, Etheresia; Akeredolu, Oore-Ofe; Soma, Prashilla; Kell, Douglas B.(Sage, 2017-02)
We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This ...
Repsold, Lisa; Pool, Roger; Karodia, M.; Tintinger, Gregory Ronald; Joubert, Annie M.(BioMed Central, 2017-10-10)
Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years
of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related ...
Venter, Chantelle; Oberholzer, Hester Magdalena; Bester, Janette; Van Rooy, Mia-Jeanne; Bester, Megan Jean(Karger Publishers Open Access, 2017)
BACKGROUND/AIMS : Heavy metal pollution is increasing in the environment, contaminating
water, food and air supplies. This can be linked to many anthropogenic activities. Heavy metals
are absorbed through the skin, ...
Sibutramine is known to be effective in the treatment of obesity and is used worldwide by millions. It acts on the central nervous system by inhibiting the neuronal reuptake of serotonin and noradrenaline; there by also ...
Pretorius, Etheresia; Mbotwe, Sthembile; Kell, Douglas B.(Nature Publishing Group, 2017-08-29)
Type 2 diabetes (T2D) has many cardiovascular complications, including a thrombotic propensity. Many
such chronic, inflammatory diseases are accompanied (and may be exacerbated, and possibly even
largely caused) by ...
Clomiphene citrate (CC) is the leading treatment for women with anovulatory infertility. The precise mechanism of action of the drug on the hypothalamic-pituitary-gonadal (HPG) axis has yet to be determined. Neurons ...
17β-Estradiol (E2) and progesterone (P4) have various important functions but the effect of
these endogenous hormone concentrations on fibrin network formation has not been
established. It is essential to understand natural ...
Diabetes mellitus has emerged as a major public health problem with pandemic
growth as the International Diabetes Federation estimates that there were 415
million diabetics in 2015 with that number reaching 642 million ...
Osteoclasts are large,multinucleated cells that are responsible for the breakdown or resorption
of bone during bone remodelling. Studies have shown that certain fatty acids (FAs) can increase bone
formation, reduce bone ...
Visagie, M.H. (Michelle Helen); Van den Bout, Jan Iman; Joubert, Annie M.(Public Library of Science, 2017-04-14)
Clinical trials have revealed that the potential anticancer agent, 2-methoxyestradiol (2ME2)
has limitations due to its low bioavailability. Subsequently, 2ME2 derivatives including (8R,
13S,14S,17S)-2-ethyl-13-methyl- ...
Verwey, M.; Joubert, Annie M.; Visagie, M.H. (Michelle Helen); Annie M.; Theron, A.E.(Biomedical Research Press, 2016)
Breast cancer is the most prevalent cancer in women worldwide, contributing to 14% of all new
cancer cases and 6.8% of all cancer deaths in 2014. A new area of cancer research has arisen
from the discovery of cancer ...
Singh, A.; Kruger, T.P.J. (Tjaart)(AOSIS Open Journals, 2016)
Photosynthesis
involves the main plant light-harvesting complex (LHCII) pigments (chlorophylls
and carotenoids). These pigments absorb and transfer photoenergy to lower excited
electronic energy states. Carotenoids ...