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Physiology
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(Allied Academies, 2018)Much research over the past five decades has focussed on the repair and replacement of bone. Recently, the research focus has shifted to nanotechnology since it provides a platform from which to alter and possibly improve ...
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(Allied Academies, 2018)2-methoxyestradiol (2ME) is an endogenous 17β-oestradiol metabolite that exerts antiproliferative, antiangiogenic and antitumour activity on cancer cells both in vitro and in vivo. However, the use of 2ME as a potential ...
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(Sage, 2018)Water contamination with metals due to anthropogenic activity is increasing and subsequent exposure increases the risk of associated toxicity. Exposure is not limited to a single metal but usually involves mixtures of ...
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(Elsevier, 2019-03)Bone is a dynamic tissue that is constantly remodelled by bone resorbing osteoclasts and bone forming osteoblasts, respectively. A breakdown in the remodelling process underlies several bone diseases such as osteoporosis. ...
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Cancer stem cells in head and neck carcinomas : identification and possible therapeutic implications (Springer, 2017-11)The recurrence and/or lack of response of certain tumors to radio- and chemotherapy has been attributed to a small subpopulation of cells termed cancer stem cells (CSCs). CSCs have been identified in many tumors (including ...
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(MDPI Publishing, 2018)Following exposure of cells to gamma-radiation, a cascade of intracellular consequences may be observed in a semitemporal manner. This includes deoxyribonucleic acid (DNA) damage and reactive oxygen species (ROS) ...
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(University of Pretoria, 2018)Pentachlorophenol (PCP) is an organochloride pesticide that is ubiquitous within the environment due to its chemical stability. It is classified as a persistent organic pollutant, and has been predominantly used in the ...
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(University of Pretoria, 2018)Background: The underlying risk factor of non-communicable diseases is inflammation. The pathophysiology of asthma and/or allergic asthma is also, no surprisingly, also linked to chronic inflammation. The prevalence and ...
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Reliability of baseline concussion test results in youth athletes from two consecutive sport seasons (University of Pretoria, 2018)Background: Concussion is a common injury reported in high velocity or contact sport, and a large amount of controversy regarding set protocols for proper management still remains. However, neuropsychological testing, done ...
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(AOSIS, 2018-09-11)Pellagra is characterised by dermatological, gastrointestinal and neuropsychiatric manifestations. Millions contracted the disease and hundreds of thousands died between the time it was first recorded until pellagra was ...
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(Bentham Science, 2018)BACKGROUND : Individuals with Type II Diabetes (T2D) have to manage blood glucose levels to sustain health and longevity. Artificial sweeteners (including aspartame) are suggested sugar alternatives for these individuals. ...
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(Frontiers Media, 2018-08-22)Many studies indicate that there is a (mainly dormant) microbial component in the progressive development of Alzheimer-type dementias (ADs); and that in the case of Gram-negative organisms, a chief culprit might be the ...
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(De Gruyter Open, 2018-09)In our previous paper, we showed that three primaquine-cinnamic acid conjugates composed of primaquine (PQ) residue and cinnamic acid derivatives (CADs) bound directly by an amide linkage (1) or through an acylsemicarbazide ...
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(Dove Medical Press, 2018)BACKGROUND : A and B rings of the steroidal microtubule disruptor, 2-methoxyestradiol, and its analogs can be mimicked with a tetrahydroisoquinoline (THIQ) core. THIQs are cytotoxic agents with potential anticancer activities. ...
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(Future Science, 2018-09)AIM : To determine the computer-predicted anticancer activity of antibiotic batumin. MATERIALS AND METHODS : Cytotoxicity assays, cell morphology microscopy and cell cycle progression were studied in cancer and nontumorigenic ...
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(BioMed Central, 2018-05-04)Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ...
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(Royal Society of Chemistry, 2018-05)Rooibos tea is a naturally sweet and aromatic tea that is native to the Western Cape province of South Africa. Rooibos is usually fermented to produce the traditional reddish brown colour and has been found to have numerous ...
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(Endocrine Society, 2017-11)CONTEXT : Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated ...
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(MDPI Publishing, 2018-04-11)Deoxyribonucleic acid (DNA) is the self-replicating hereditary material that provides a blueprint which, in collaboration with environmental influences, produces a structural and functional phenotype. As DNA coordinates ...
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(Lippincott, Williams & Wilkins, 2018-06)This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute ...