• Effects of clomiphene citrate on the expression of kisspeptin dynorphin A and neurokinin B in female Sprague-Dawley rats 

  Fourie, Christle (University of Pretoria, 2017)

  Clomiphene citrate (CC) is the leading treatment for women with anovulatory infertility. The precise mechanism of action of the drug on the hypothalamic-pituitary-gonadal (HPG) axis has yet to be determined. Neurons ...
• The effects of physiological concentrations of 17ß-Estradiol and Progesterone on fibrin network ultrastructure 

  Visagie, Amcois (University of Pretoria, 2017)

  17β-Estradiol (E2) and progesterone (P4) have various important functions but the effect of these endogenous hormone concentrations on fibrin network formation has not been established. It is essential to understand natural ...
• Inflammatory markers and ultrastructure of the coagulation profile in diabetes mellitus 

  Soma, Prashilla (University of Pretoria, 2017)

  Diabetes mellitus has emerged as a major public health problem with pandemic growth as the International Diabetes Federation estimates that there were 415 million diabetics in 2015 with that number reaching 642 million ...
• Palmitoleic acid inhibits RANKL-induced osteoclastogenesis and bone resorption by suppressing NF- B and MAPK signalling pathways 

  Van Heerden, Bernadette; Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (MDPI Publishing, 2017-04-28)

  Osteoclasts are large,multinucleated cells that are responsible for the breakdown or resorption of bone during bone remodelling. Studies have shown that certain fatty acids (FAs) can increase bone formation, reduce bone ...
• A bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis 

  Visagie, M.H. (Michelle Helen); Van den Bout, Jan Iman; Joubert, Annie M. (Public Library of Science, 2017-04-14)

  Clinical trials have revealed that the potential anticancer agent, 2-methoxyestradiol (2ME2) has limitations due to its low bioavailability. Subsequently, 2ME2 derivatives including (8R, 13S,14S,17S)-2-ethyl-13-methyl- ...
• Chemoresistance in breast cancer stem cells 

  Verwey, M.; Joubert, Annie M.; Visagie, M.H. (Michelle Helen); Annie M.; Theron, A.E. (Biomedical Research Press, 2016)

  Breast cancer is the most prevalent cancer in women worldwide, contributing to 14% of all new cancer cases and 6.8% of all cancer deaths in 2014. A new area of cancer research has arisen from the discovery of cancer ...
• Ondersoek na die opgewekte elektroniese toestande van karotenoïede in die hoofligversamelingskompleks van plante (LHCII) deur femtosekondepompproefspektroskopie 

  Singh, A.; Kruger, T.P.J. (Tjaart) (AOSIS Open Journals, 2016)

  Photosynthesis involves the main plant light-harvesting complex (LHCII) pigments (chlorophylls and carotenoids). These pigments absorb and transfer photoenergy to lower excited electronic energy states. Carotenoids ...
• Tissue factor levels in type 2 diabetes mellitus 

  Soma, Prashilla; Swanepoel, A.C. (Albe Carina); Bester, Janette; Pretorius, Etheresia (Springer, 2017-05)

  INTRODUCTION : Type 2 diabetes mellitus is a pandemic associated with disturbance inhaemostasis that could contribute to the development of diabetic vascular disease and accelerated atherosclerosis. In this population, ...
• Ellagic acid inhibits RANKL-induced osteoclast differentiation by suppressing the p38 MAP kinase pathway 

  Rantlha, Mpho; Sagar, Travers; Kruger, Marlena C.; Coetzee, Magdalena; Deepak, Vishwa (Springer, 2017-01)

  Bone undergoes continuous remodeling by a coupled action between osteoblasts and osteoclasts. During osteoporosis, osteoclast activity is often elevated leading to increased bone destruction. Hence, osteoclasts are deemed ...
• Interrelation between inflammation, thrombosis, and neuroprotection in cerebral ischemia 

  Van der Spuy, Wendy Jeannette; Pretorius, Etheresia (De Gruyter, 2012-05)

  Stroke by mechanism of thrombotic cerebral ischemia is one of the leading causes of death and/or disability worldwide. Current research is under consensus that there are sex-based differences in both the prevalence and ...
• A bacterial component to Alzheimer's-type dementia seen via a systems biology approach that links iron dysegulation and inflammagen shedding to disease 

  Pretorius, Etheresia; Bester, Janette; Kell, Douglas B. (IOS Press (open access), 2016-06)

  The progression of Alzheimer’s disease (AD) is accompanied by a great many observable changes, both molecular and physiological. These include oxidative stress, neuroinflammation, and (more proximal to cognitive decline) ...
• Efficacy of phenotypic, PCR and MALDI -ToF identification methods for Campylobacter spp. 

  Phulukdaree, Alisa; Bester, L.A.; Khan, N.; Essack, S.Y. (Society of Medical Laboratory Technologists of South Africa, 2016-06)

  This study compared phenotypic and genotypic identification methods of Campylobacter spp. against the polymerase chain reaction (PCR) in terms of sensitivity, specificity, positive-predictive value and negative-predictive ...
• Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation : lessons from and for blood clotting 

  Pretorius, Etheresia; Kell, D.B. (Elsevier, 2017-01)

  The chief and largely terminal element of normal blood clotting is considered to involve the polymerisation of the mainly α-helical fibrinogen to fibrin, with a binding mechanism involving ‘knobs and holes’ but with otherwise ...
• Pro-inflammatory cytokine levels in HIV infected and uninfected pregnant women with and without preeclampsia 

  Phulukdaree, Alisa; Maharaj, Niren Ray; Nagiah, Savania; Ramkaran, Prithiksha; Tiloke, Charlette; Chuturgoon, Anil Amichund (Public Library of Science, 2017-01)

  INTRODUCTION Preeclampsia and HIV/AIDS are inflammatory conditions that contribute significantly to adverse maternal and foetal outcomes. The immune reconstitution effects of HAART on inflammatory mediators has not been ...
• Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide 

  Pretorius, Etheresia; Mbotwe, Sthembile; Bester, Janette; Robinson, Christopher J.; Kell, Douglas B. (The Royal Society, 2016)

  It is well known that a variety of inflammatory diseases are accompanied by hypercoagulability, and a number of more-or-less longer-term signalling pathways have been shown to be involved. In recent work, we have suggested ...
• Autophagy induced by a sulphamoylated estrone analogue contributes to its cytotoxic effect on breast cancer cells 

  Verwey, M.; Nolte, Elsie M.; Joubert, Annie M.; Theron, A.E. (Anne Elisabeth) (BioMed Central, 2016-12-08)

  BACKGROUND : Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in ...
• A comprehensive review on Eryptosis 

  Pretorius, Etheresia; Du Plooy, Jeanette Noel; Bester, J. (Karger Publishers Open Access, 2016)

  Erythrocytes (RBCs) are extremely sensitive cells, and although they do not have nuclei and mitochondria, are important health indicators. This is particularly true because, during inflammation, whether it is systemic ...
• Ex vivo apoptotic and autophagic influence of an estradiol analogue on platelets 

  Repsold, Lisa; Pretorius, Etheresia; Joubert, Annie M. (BioMed Central, 2016-07-15)

  BACKGROUND : Platelets are known contributors to the vascularization, metastasis and growth of tumors. Upon their interaction with cancer cells they are activated resulting in degranulation and release of constituents. ...
• Expression of the H- and L-subunits of ferritin in bone marrow macrophages of patients with osteoarthritis 

  Koorts, Alida Maria; Becker, Petrus Johannes; Viljoen, Margaretha; Levay, Peter Ferenc; Hall, Alan Norman; Van der Merwe, Christiaan Frederick; Frantzen, Doron Johan Manuel (Sage, 2012)

  Osteoarthritis is a disease characterized by an increase in the production of reactive oxygen species (ROS) in afflicted joints. Excess iron, due to its role in the production of ROS and crystal deposition in the joints, ...
• 2-Methoxyestradiol-bis-sulphamate : a promising anticancer agent in an esophageal carcinoma (SNO) cell line 

  Mqoco, T.V. (Thandi Vuyelwa); Marais, Sumari; Joubert, Annie M. (Biomedical Research Press, 2013)

  2-Methoxyestradiol-bis-sulphamate (2-MeOE2bisMATE) is a bis-sulphamoylated analogue of a biological estradiol metabolite, 2-methoxyestradiol (2ME2) with potential as an anticancer drug. The aim of this in vitro study was ...

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