BACKGROUND : Personal health behaviours and lifestyle habits of health professionals influence their counselling practices related to non-communicable diseases (NCDs). There are limited data on the prevalence of unhealthy ...
INTRODUCTION :
Pharmacology is an increasingly important area of study for oral hygienists, as it provides the scientific basis for safe and effective oral healthcare. However, a lack of fundamental understanding of the ...
PURPOSE :
Artificial intelligence (AI) refers to technology capable of mimicking human cognitive functions and has important applications across all sectors and industries, including drug development. This has considerable ...
Melanoma is an aggressive malignancy and remains a major cause of skin cancer mortality, highlighting the need for new treatment strategies. Recent findings revealed that L-kynurenine and quinolinic acid induce cytotoxicity ...
Nkandeu, D.S. (Danielle Sandra); Joubert, Anna Margaretha; Serem, June Cheptoo; Bipath, Priyesh; Hlophe, Yvette Nkondo(Wiley, 2024-06)
Cancer is the second leading cause of mortality worldwide. The development of anticancer therapy plays a crucial role in mitigating tumour progression and metastasis. Epithelioid hemangioendothelioma is a very rare cancer, ...
Peta, Kimberly; Durandt, Chrisna; Van Heerden, Marlene B.; Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi(Wiley, 2024-04)
BACKGROUND :
The anti-cancer agent 2-methoxyestradiol (2-ME) has been shown to have anti-proliferative and anti-angiogenic properties. Previously, the effect of 2-ME on early- and late-stage breast cancer (BC) was ...
Du Toit, Francois; Schwellnus, Martin Peter; Jordaan, Esme; Swanevelder, Sonja; Wood, Paola Silvia(Taylor and Francis, 2023)
OBJECTIVE :
Gradual onset injuries (GOIs) in recreational cyclists are common but not well described. The aim of this study is to describe the clinical characteristics of GOIs (main anatomical regions, specific anatomical ...
Sibanda, Sthembile Valencia(University of Pretoria, 2019)
Inflammation is a well-known underlying cause in many diseases. Chronic inflammation has a role in a host of common and often deadly diseases, including Alzheimer’s disease, rheumatoid arthritis, cancer, type 2 diabetes, ...
The purpose of this study was to determine the effects of whole-body electromyostimulation (WB-EMS) augmented calisthenic training on physique, maximum strength, balance and aerobic endurance and compare said effects to ...
Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato-based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when it is used ...
Radomsky, Tarryn; Anderson, Ross Calley; Millar, Robert P.; Newton, Claire L.(Wiley, 2024-09)
G protein-coupled receptors (GPCRs) are central to the functioning of the hypothalamic–pituitary–gonadal axis (HPG axis) and include the rhodopsin-like GPCR family members, neurokinin 3 receptor, kappa-opioid receptor, ...
Oral hormonal contraceptive users carry the risk of venous thrombosis and increased mortality. This study aimed to comprehensively profile the serum metabolome of participants using a combination of drospirenone (DRSP) and ...
Stark, Michael Christopher; Joubert, Anna Margaretha; Visagie, Michelle Helen(MDPI, 2023-06)
Immune checkpoint inhibitors (ICIs) are a class of immunotherapy agents capable of
alleviating the immunosuppressive effects exerted by tumorigenic cells. The programmed cell
death protein 1 (PD-1)/programmed death-ligand ...
Nolte, Elsie Magdalena; Joubert, Anna Margaretha; Lafanechere, Laurence; Mercier, Anne Elisabeth(MDPI, 2023-02)
Radiation resistance and radiation-related side effects warrant research into alternative
strategies in the application of this modality to cancer treatment. Designed in silico to improve the
pharmacokinetics and anti-cancer ...
CTCE-9908, a CXC chemokine receptor 4 (CXCR4) antagonist, prevents CXCR4 phosphorylation and inhibits the interaction with chemokine ligand 12 (CXCL12) and downstream signalling pathways associated with metastasis. This ...
Peta, Kimberly Thando; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi(Wiley, 2023-10)
The prevalence of breast cancer (BC) continues to increase and is the leading cause
of cancer deaths in many countries. Numerous in vitro and in vivo studies have
demonstrated that 2‐methoxyestradiol (2‐ME) has ...
The metastatic behavior of melanoma has accentuated the need for specific therapy
targets. Compounds, namely L‐kynurenine (L‐kyn), quinolinic acid (Quin), and kynurenic
acid (KA) previously displayed antiproliferative ...