Oral hormonal contraceptive users carry the risk of venous thrombosis and increased mortality. This study aimed to comprehensively profile the serum metabolome of participants using a combination of drospirenone (DRSP) and ...
Stark, Michael Christopher; Joubert, Anna Margaretha; Visagie, Michelle Helen(MDPI, 2023-06)
Immune checkpoint inhibitors (ICIs) are a class of immunotherapy agents capable of
alleviating the immunosuppressive effects exerted by tumorigenic cells. The programmed cell
death protein 1 (PD-1)/programmed death-ligand ...
Nolte, Elsie Magdalena; Joubert, Anna Margaretha; Lafanechere, Laurence; Mercier, Anne Elisabeth(MDPI, 2023-02)
Radiation resistance and radiation-related side effects warrant research into alternative
strategies in the application of this modality to cancer treatment. Designed in silico to improve the
pharmacokinetics and anti-cancer ...
CTCE-9908, a CXC chemokine receptor 4 (CXCR4) antagonist, prevents CXCR4 phosphorylation and inhibits the interaction with chemokine ligand 12 (CXCL12) and downstream signalling pathways associated with metastasis. This ...
Peta, Kimberly; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi(Wiley, 2023-10)
The prevalence of breast cancer (BC) continues to increase and is the leading cause
of cancer deaths in many countries. Numerous in vitro and in vivo studies have
demonstrated that 2‐methoxyestradiol (2‐ME) has ...
The metastatic behavior of melanoma has accentuated the need for specific therapy
targets. Compounds, namely L‐kynurenine (L‐kyn), quinolinic acid (Quin), and kynurenic
acid (KA) previously displayed antiproliferative ...
Van Heerden, David; Klima, Stefanie; Van den Bout, Iman(Elsevier, 2024-02)
The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The ...
BACKGROUND : Non-communicable diseases are often associated with chronic inflammation, placing patients suffering from these conditions at a higher risk of thrombosis and other complications. The pathophysiology of asthma ...
De Jager, Izaan; Schwellnus, Martin Peter; Sewry, Nicola; Viljoen, Carel Thomas; Korkie, Elzette; Swanevelder, Sonja; Jordaan, Esme(Lippincott Williams and Wilkins, 2023-09)
OBJECTIVE :
To determine independent risk factors associated with a history of exercise-associated muscle cramps (hEAMCs) in distance runner race entrants in a community-based mass participation event.
DESIGN : ...
Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman(MDPI, 2023-05-19)
Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical
drug testing platforms, as they circumvent limitations associated with traditional monolayer cell
cultures. However, many of these ...
Melanoma, an invasive class of skin cancer, originates from mutations in melanocytes, the pigment-producing cells. Globally, approximately 132,000 new cases are reported each year, and in South Africa, the incidence stands ...
OBJECTIVE : To investigate the frequency and trajectories of individual patients with polyarticular-course juvenile idiopathic arthritis (JIA) achieving novel composite end points on abatacept.
METHODS : Data from a ...
Donaldson, Byron John(University of Pretoria, 2023-09-29)
Initial sprint acceleration is a complex and dynamic skill, requiring the application of large forces to propel the body forwards. Effective force application is achieved through the use of joint and segment rotations in ...
Identifying coordination strategies used by sprinters and features that differentiate these strategies will aid in understanding different technical approaches to initial sprint acceleration. Moreover, multiple effective ...
Smith, Chanel; Sewry, Nicola; Nolte, Kim; Swanevelder, Sonja; Engelke, Nina; Van Kamp, Calvin; Jordaan, Esme; Schwellnus, Martin Peter(Taylor and Francis, 2024)
OBJECTIVES : Currently, there are five international screening tools that are recommended to identify individuals who require pre-exercise medical clearance to reduce the risk of medical encounters during exercise. Therefore, ...
Morris, Chanel; Potgieter, Johan C.; Bester, Janette(Sage, 2023)
BACKGROUND : Haemophilia A (HA) is a bleeding disorder, due to a deficiency in factor VIII (FVIII). These patients are unable to produce a stable fibrin clot in the propagation phase of coagulation as they do not generate ...
Van Zyl, Sanet; Bayne, Helen; Schwellnus, Martin Peter; Viljoen, Carel Thomas(Elsevier, 2024-01)
OBJECTIVES : Determine the epidemiology and clinical characteristics of training and match injuries in university student rugby players over a two-season period.
DESIGN : Prospective cohort.
SETTING : Varsity Cup (VC) ...