• In vitro cytotoxicity and in vivo sub-acute toxicity studies on Vitex doniana (Verbenaceae) leaves extract in MCF-7 breast cancer cells and female Wistar rats 

  Forcados, Gilead Ebiegberi; James, Dorcas Bolanle; Scoltz, Wihan; Mabeta, Peaceful Lucy (Springer, 2021-06)

  Vitex doniana leaves are used in traditional medicine systems for the treatment of inflammatory-related disorders and breast cancer in West Africa. However, there is a dearth of scientific evidence on the effectiveness of ...
• Apoptotic profiling of chronic myeloid leukaemia patients' platelets ex vivo before and after treatment with Imatinib 

  Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Becker, Piet J.; Joubert, Anna Margaretha (Wiley, 2021-06)

  Chronic myeloid leukaemia (CML) is a malignancy of the haematopoietic stem cells. The first line of treatment for CML, especially in developing countries, remains the first-generation tyrosine kinase inhibitor, Imatinib. ...
• Pellagra in South Africa from 1897 to 2019 : a scoping review 

  Viljoen, Margaretha; Bipath, Priyesh; Tosh, Cheryl A. (Cambridge University Press, 2021-06)

  OBJECTIVE : Pellagra is a nutritional deficiency disease associated with niacin (vitamin B3) deficiency. The history of pellagra is well documented for Europe and the USA, but less is known about the prevalence in sub-Saharan ...
• Comparative upper-quarter posture analysis of female adolescent freestyle swimmers and non-swimmers 

  Botha, Carolin-Mari; Rossouw, France; Meyer, P.W.A. (Pieter Willem Adriaan); Camacho, Tanya Chantelle de Sousa (Routledge, 2022)

  Repetitive upper-quarter limb movements imposed by freestyle swimming may lead to muscle length and tension changes, predisposing adolescent swimmers to postural malalignment. The study aimed to quantify the static ...
• Intracellular signaling responses induced by radiation within an in vitro bone metastasis model after pre-treatment with an estrone analogue 

  Helena, Jolene Michelle; Joubert, Anna Margaretha; Mabeta, Peaceful Lucy; Coetzee, Magdalena; Lakier, Roy; Mercier, Anne Elisabeth (MDPI, 2021-08-17)

  2-Ethyl-3-O-sulfamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is an in silico-designed estradiol analogue which has improved the parent compound’s efficacy in anti-cancer studies. In this proofof- concept study, the potential ...
• Resting energy expenditure and related factors in 6- to 9-year-old Southern African children of diverse population groups 

  Pretorius, Adeline; Wood, Paola Silvia; Becker, Piet J.; Wenhold, F.A.M. (Friedeburg Anna Maria) (MDPI, 2021-06)

  Lower resting energy expenditure (REE) may partially explain the disproportionate prevalence of overweight/obesity among black African women. As no previous studies have investigated the REE of Southern African (South. ...
• Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa 

  De Beer, Rene; Outhoff, Kim; Phulukdaree, Alisa; Soma, Prashilla (Taylor and Francis, 2021)

  Statins, the standard treatment for hypercholesterolaemia, among the most widely prescribed, have been associated with side effects, including statin intolerance. The aim of this study was to determine the background ...
• Repeated annual health risk assessments with intervention did not reduce 10-year cardiovascular disease risk A 4-year longitudinal study in 13,737 financial sector employees 

  Hene, Nceba; Wood, Paola Silvia; Schwellnus, Martin Peter; Jordaan, Esme; Laubscher, Ria (Lippincott Williams and Wilkins, 2021-10)

  OBJECTIVE : To determine if repeat annual health risk assessments (RAHRAs) with intervention reduce 10-year cardiovascular disease (CVD) risk in financial sector employees. METHODS : Retrospective analysis from RAHRAs in ...
• High prevalence of non-communicable diseases risk factors in 36,074 South African financial sector employees : a cross-sectional study 

  Hene, Nceba; Wood, Paola Silvia; Schwellnus, Martin Peter; Jordaan, Esme; Laubscher, Ria (Lippincott, Williams & Wilkins, 2021-02)

  OBJECTIVE : To determine the prevalence of non-communicable disease (NCD) risk factors, total NCD risk category and 10-year risk for cardiovascular diseases (CVD) in financial sector employees. METHODS : This descriptive ...
• Reciprocal integrin/integrin antagonism through kindlin-2 and Rho GTPases regulates cell cohesion and collective migration 

  Van der Bijl, Ivo; Nawaz, Kalim; Kazlauskaite, Ugne; Van Stalborch, Anne-Marieke; Tol, Simon; Jimenez Orgaz, Ana; Van den Bout, Jan Iman; Reinhard, Nathalie R.; Sonnenberg, Arnoud; Margadant, Coert (Elsevier, 2020-11)

  Collective cell behaviour during embryogenesis and tissue repair requires the coordination of intercellular junctions, cytoskeleton-dependent shape changes controlled by Rho GTPases, and integrin-dependent cell-matrix ...
• A cytotoxic bis(1,2,3-triazol-5-ylidene)carbazolide gold(III) complex targets DNA by partial intercalation 

  Van der Westhuizen, Danielle; Slabber, Cathryn A.; Fernandes, Manuel A.; Joubert, Daniel Francois; Kleinhans, George; Van der Westhuizen, Carl Johan; Stander, Andre; Munro, Orde; Bezuidenhout, Daniela Ina (Wiley, 2021-06)

  The syntheses of bis(triazolium)carbazole precursors and their corresponding coinage metal (Au, Ag) complexes are reported. For alkylated triazolium salts, di- or tetranuclear complexes with bridging ligands were isolated, ...
• Health science community will miss this bright and uniting star : in memory of Professor Gjumrakch Aliev, M.D, Ph.D 

  Chubarev, Vladimir N.; Beeraka, Narasimha M.; Sinelnikov, Mikhail Y.; Bulygin, Kirill V.; Nikolenko, Vladimir N.; Mihaylenko, Elizaveta; Tarasov, Vadim V.; Mikhaleva, Liudmila M.; Poltronieri, Palmiro; Viswanadha, Vijaya Padma; Somasundaram, Siva G.; Kirkland, Cecil E.; Chen, Kuo; Liu, Junqi; Fan, Ruitai; Kamal, Mohammad Amjad; Mironov, Alexander A.; Madhunapantula, SubbaRao V.; Pretorius, Etheresia; Dindyaev, Sergey V.; Muresanu, Cristian; Sukocheva, Olga A. (MDPI, 2021-04)

  No abstract available
• Biomechanics without borders : teaching biomechanics in Brazil and South Africa 

  Bayne, Helen; Albertus, Yumna; Breen, Sarah; Green, Andrew; De Andrade, Andre Gustavo; Kramer, Mark; Carpes, Felipe P. (American Physiological Society, 2021-03)

  The “Biomechanics without Borders: Teaching Biomechanics in Brazil and South Africa” involved academics from different countries combining efforts to improve remote education. In addition to the live discussions, the event ...
• Biomechanics without borders : teaching biomechanics in Brazil and South Africa 

  Bayne, Helen; Albertus, Yumna; Breen, Sarah; Green, Andrew; De Andrade, Andre Gustavo; Kramer, Mark; Carpes, Felipe P. (American Physiological Society, 2021)

  The “Biomechanics without Borders: Teaching Biomechanics in Brazil and South Africa” involved academics from different countries combining efforts to improve remote education. In addition to the live discussions, the event ...
• Cancer genomics 

  Joubert, Annie M. (Academy of Science South Africa, 2020)

  No abstract available.
• Cholecalciferol inhibits cell growth and induces apoptosis in the CaSki cell line 

  Bhoora, Sachin; Pather, Yuvelia; Marais, Sumari; Punchoo, Rivak (MDPI, 2020-02)

  Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. ...
• Patulin suppresses α1‑adrenergic receptor expression in HEK293 cells 

  Pillay, Yashodani; Nagiah, Savania; Phulukdaree, Alisa; Krishnan, Anand; Chuturgoon, Anil A. (Nature Publishing Group, 2020-11-18)

  Patulin (PAT) is a common mycotoxin contaminant of apple products linked to impaired metabolic and kidney function. Adenosine monophosphate activated protein kinase (AMPK), abundantly expressed in the kidney, intercedes ...
• Effects of a 6-month exercise programme on disease activity, physical and functional parameters in patients with ankylosing spondylitis : randomised controlled trial 

  Nolte, Kim; Janse van Rensburg, Dina Christina; Fletcher, Lizelle (OASIS, 2021-06)

  BACKGROUND : Respiratory morbidity is common in children with neuromuscular diseases (NMD) owing to chronic hypoventilation and impaired cough. Optimal, cost-effective respiratory management requires implementation of ...
• The effect of infraslow frequency neurofeedback on autonomic nervous system function in adults with anxiety and related diseases 

  Balt, Karlien; Du Toit, Peet J.; Smith, Mark; Janse van Rensburg, Charl (International Society for Neurofeedback & Research, 2020-06)

  Peripheral body monitoring of autonomic nervous system (ANS) response has been routinely applied during infraslow fluctuation (ISF) neurofeedback training. This study hypothesized that ISF training has a distinct physiological ...
• Potential protective effects of neonatal supplementation with oleanolic acid on peroxisome proliferator-activated receptor gamma (PPARγ)-ligand dependent regulation of glucose homeostasis in high fructose-fed rats 

  Mosana, Mmahiine; Ayeleso, Ademola; Nyakudya, Trevor Tapiwa; Erlwanger, Kennedy; Mukwevho, Emmanuel (Natural Product, 2020)

  The effect of neonatal oral supplementation of oleanolic acid (OA) on peroxisome proliferator-activated receptor gamma (PPARγ)-1 on glucose homeostasis in high fructose-fed rats was investigated. Rat pups (7 days old) ...

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