• Aspartame : should individuals with Type II diabetes be taking it? 

  Choudhary, Arbind Kumar (Bentham Science, 2018)

  BACKGROUND : Individuals with Type II Diabetes (T2D) have to manage blood glucose levels to sustain health and longevity. Artificial sweeteners (including aspartame) are suggested sugar alternatives for these individuals. ...
• The potential of LPS-binding protein to reverse amyloid formation in plasma fibrin of individuals with Alzheimer-type dementia 

  Pretorius, Etheresia; Bester, Janette; Page, Martin J.; Kell, Douglas B. (Frontiers Media, 2018-08-22)

  Many studies indicate that there is a (mainly dormant) microbial component in the progressive development of Alzheimer-type dementias (ADs); and that in the case of Gram-negative organisms, a chief culprit might be the ...
• Insights into the mechanism of antiproliferative effects of primaquine-cinnamic acid conjugates on MCF-7 cells 

  Mabeta, Peaceful Lucy; Pavic, Kristina; Zorc, Branka (De Gruyter Open, 2018-09)

  In our previous paper, we showed that three primaquine-cinnamic acid conjugates composed of primaquine (PQ) residue and cinnamic acid derivatives (CADs) bound directly by an amide linkage (1) or through an acylsemicarbazide ...
• Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines 

  Nel, Marcel; Joubert, Anna Margaretha; Dohle, Wolfgang; Potter, Barry V.L.; Theron, A.E. (Anne Elisabeth) (Dove Medical Press, 2018)

  BACKGROUND : A and B rings of the steroidal microtubule disruptor, 2-methoxyestradiol, and its analogs can be mimicked with a tetrahydroisoquinoline (THIQ) core. THIQs are cytotoxic agents with potential anticancer activities. ...
• Promising anticancer activity of batumin : a natural polyene antibiotic produced by Pseudomonas batumici 

  Soldatkina, Maria.A.; Klochko, Vitalii V.; Zagorodnya, Svitlana D.; Rademan, Sunelle; Visagie, M.H. (Michelle Helen); Lebelo, M.T. (Maphuti); Gwangwa, Mokgadi Violet; Joubert, Anna Margaretha; Lall, Namrita; Reva, Oleg N. (Future Science, 2018-09)

  AIM : To determine the computer-predicted anticancer activity of antibiotic batumin. MATERIALS AND METHODS : Cytotoxicity assays, cell morphology microscopy and cell cycle progression were studied in cancer and nontumorigenic ...
• Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis 

  Gwangwa, Mokgadi Violet; Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (BioMed Central, 2018-05-04)

  Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ...
• Rooibos tea extracts inhibit osteoclast formation and activity through the attenuation of NF-κB activity in RAW264.7 murine macrophages 

  Moosa, Shaakirah; Kasonga, Abe E.; Deepak, Vishwa; Marais, Sumari; Magoshi, Innocentia Botlhale; Bester, Megan Jean; Kruger, Marlena C.; Coetzee, Magdalena (Royal Society of Chemistry, 2018-05)

  Rooibos tea is a naturally sweet and aromatic tea that is native to the Western Cape province of South Africa. Rooibos is usually fermented to produce the traditional reddish brown colour and has been found to have numerous ...
• Hypothalamic-pituitary-ovarian axis reactivation by kisspeptin-10 in hyperprolactinemic women with chronic amenorrhea 

  Millar, Robert P.; Sonigo, Charlotte; Anderson, Richard A.; George, Jyothis; Maione, Luigi; Brailly-Tabard, Sylvie; Chanson, Philippe; Binart, Nadine; Young, Jacques (Endocrine Society, 2017-11)

  CONTEXT : Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated ...
• Deoxyribonucleic acid damage and repair : capitalizing on our understanding of the mechanisms of maintaining genomic integrity for therapeutic purposes 

  Helena, Jolene Michelle; Joubert, Anna Margaretha; Grobbelaar, Simone; Nolte, Elsie M.; Nel, Marcel; Pepper, Michael Sean; Coetzee, Magdalena; Mercier, Anne Elisabeth (MDPI Publishing, 2018-04-11)

  Deoxyribonucleic acid (DNA) is the self-replicating hereditary material that provides a blueprint which, in collaboration with environmental influences, produces a structural and functional phenotype. As DNA coordinates ...
• Synergistic in-vitro effects of combining an antiglycolytic, 3-bromopyruvate, and a bromodomain-4 inhibitor on U937 myeloid leukemia cells 

  Kapp, Nicolette; Stander, Xiao Xing; Stander, Barend Andre (Lippincott, Williams & Wilkins, 2018-06)

  This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute ...
• A novel 2-methoxyestradiol analogue is responsible for vesicle disruption and lysosome aggregation in breast cancer cells 

  Nkandeu, D.S. (Danielle Sandra); Van den Bout, Jan Iman; Cronjé, Marianne J.; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Joubert, Anna Margaretha (Karger Publishers, 2018)

  BACKGROUND : 2-Methoxyestradiol (2ME2) is an endogenous metabolite of 17-β-estradiol with anti-proliferative and anti-angiogenic properties. Due to 2ME2’s rapid metabolism and low oral bioavailability in in vivo settings, ...
• Continuous kisspeptin restores luteinizing hormone pulsatility following cessation by a neurokinin B antagonist in female sheep 

  Clarke, Iain J.; Li, Qun; Henry, Belinda A.; Millar, Robert P. (Oxford University Press, 2018-02)

  Pulsatile secretion of the gonadotropin-releasing hormone (GnRH) drives pulsatile secretion of the luteinizing hormone (LH), with evidence that this depends on kisspeptin (Kiss) input to GnRH neurons. Kiss administration ...
• The inflammatory effects of TNF-α and complement component 3 on coagulation 

  Page, Martin J.; Bester, Janette; Pretorius, Etheresia (Nature Publishing Group, 2018-01-29)

  Tissue necrosis factor-α (TNF-α) and complement component 3 (C3) are two well-known proinflammatory molecules. When TNF-α is upregulated, it contributes to changes in coagulation and causes C3 induction. They both interact ...
• Eryptosis : an erythrocyte’s suicidal type of cell death 

  Repsold, Lisa; Joubert, Annie M. (Hindawi Publishing Corporation, 2018-01-03)

  Erythrocytes play an important role in oxygen and carbon dioxide transport. Although erythrocytes possess no nucleus or mitochondria, they fulfil severalmetabolic activities namely, the Embden-Meyerhof pathway, as well ...
• Measuring physical activity in South African grade 2 and 3 learners : a self-report questionnaire versus pedometer testing 

  Malan, Guiliame F.; Nolte, Kim (Southern African Alliance for Sport Science, Physical Education and Recreation, 2017)

  The prevalence of childhood obesity is increasing in South Africa and can be linked to decreased physical activity (PA). It is important to be able to accurately measure children’s PA levels as part of a holistic strategy ...
• The validity of arterial measurements in a South African embalmed body population 

  Schoeman, Marelize; Van Schoor, Albert-Neels; Suleman, Farhana Ebrahim; Louw, Liebie; Du Toit, Peet J. (Springer, 2018-01)

  INTRODUCTION : Knowledge of the normal arterial diameter at a given anatomical point is the first step toward quantifying the severity of cardiovascular diseases. According to several studies, parameters such as weight, ...
• Effective long-term solution to therapeutic remission in inflammatory bowel disease : role of azathioprine 

  Adam, Lyla; Phulukdaree, Alisa; Soma, Prashilla (Elsevier, 2018-04)

  Azathioprine (AZA) is a well-known immunosuppressant used for many years for its ability to ensure long term disease remission in inflammatory bowel diseases (IBD) at an affordable cost to the public. However, the side ...
• Characterizing pathology in erythrocytes using morphological and biophysical membrane properties : relation to impaired hemorheology and cardiovascular function in rheumatoid arthritis 

  Olumuyiwa-Akeredolu, Oore-ofe O.; Soma, Prashilla; Buys, A.V. (Antonia Vergina); Debusho, Legesse Kassa; Pretorius, Etheresia (Elsevier, 2017-12)

  The inflammatory burden of the complex rheumatoid arthritis (RA) disease affects several organ-systems, including rheological properties of blood and its formed elements. Red blood cells (RBCs) are constantly exposed to ...
• Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability 

  Pretorius, Etheresia; Akeredolu, Oore-Ofe; Soma, Prashilla; Kell, Douglas B. (Sage, 2017-02)

  We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This ...
• Acute megakaryoblastic leukaemia: light microscopy and scanning electron microscopy of blast cells 

  Masingi, Ntsakisi I.; Laher, Zaheer; Pretorius, Etheresia (Wiley, 2017-03)

  A 60-year-old human immunodeficiency virus-positive woman presented with splenomegaly.

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