• Comparison between plasma neopterin and the urine neopterin : creatinine ratio as inflammatory biomarkers 

  Thomas, Bianca; Bipath, Priyesh; Viljoen, Margaretha (Makerere University Medical School, 2019-09)

  BACKGROUND : Neopterin, a product of cell-mediated immunity, is a non-specific biomarker of inflammation. Plasma/serum is generally the body fluid of choice for neopterin assessment, but urine is often used as it does ...
• Glu2.53(90) of the GnRH receptor is part of the conserved G protein-coupled receptor structure and does not form a salt-bridge with Lys3.32(121) 

  Manilall, Ashmeetha; Stander, Barend Andre; Madziva, Michael Taurai; Millar, Robert P.; Flanagan, Colleen A. (Elsevier, 2019-02)

  Please read abstract in the article.
• Haematopoietic stem cell transplantation in South Africa : current limitations and future perspectives 

  Grobbelaar, Simone; Mercier, Anne Elisabeth; Verburgh, Estelle; Brittain, David; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)

  The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. HSCT provides life-changing and potentially curative therapy for a ...
• A possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura : results from a pilot study 

  De Villiers, Sulette; Bester, Janette; Kell, Douglas B.; Pretorius, Etheresia (Frontiers Media, 2019-11-26)

  INTRODUCTION : Migraine is a debilitating primary headache disorder with a poorly understood aetiology. An extensive body of literature supports the theory of migraine as a systemic vascular inflammatory disorder characterised ...
• Scribbling the cat : a case of the “miracle” plant, Moringa oleifera 

  Tshabalala, Thulani; Ncube, Bhekumthetho; Madala, Ntakadzeni Edwin; Nyakudya, Trevor Tapiwa; Moyo, Hloniphani Peter; Sibanda, Mbulisi; Ndhlala, Ashwell Rungano (MDPI Publishing, 2019-11-15)

  This paper reviews the properties of the most cultivated species of the Moringaceae family, Moringa oleifera Lam. The paper takes a critical look at the positive and the associated negative properties of the plant, with ...
• Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome 

  Maione, Luigi; Fevre, Anne; Nettore, Immacolata Cristina; Manilall, Ashmeetha; Francou, Bruno; Trabado, Severine; Bouligand, Jerome; Guiochon-Mantel, Anne; Delemer, Brigitte; Flanagan, Colleen A.; Macchia, Paolo Emidio; Millar, Robert P.; Young, Jacques (Oxford University Press, 2019-01)

  STUDY QUESTION : Does the phenotype of women with normosmic congenital hypogonadotrophic hypogonadism (nCHH) and pituitary resistance to GnRH caused by biallelic mutations in the GnRH receptor (GNRHR) (nCHH/bi-GNRHR) differ ...
• A combination of an antimitotic and a bromodomain 4 inhibitor synergistically inhibits the metastatic MDA-MB-231 breast cancer cell line 

  Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Engelbrecht, Anna-Mart; Joubert, Annie M. (Hindawi Publishing, 2019-12-11)

  Current chemotherapeutic agents have many side effects and are toxic to normal cells, providing impetus to identify agents that can effectively eliminate tumorigenic cells without damaging healthy cells. The aim of this ...
• Cytotoxic activity of pentachlorophenol and its active metabolites in SH-SY5Y neuroblastoma cells 

  Fraser, Desiree Linda; Stander, Barend Andre; Steenkamp, Vanessa (Elsevier, 2019-08)

  As knowledge regarding mechanisms of pentachlorophenol (PCP) toxicity in neuronal cell lines is limited, the aim of the study was to evaluate the effects of PCP and its active metabolites, tetrachloro-1,4-benzoquinone ...
• Long-term safety and efficacy of alirocumab in South African patients with heterozygous familial hypercholesterolaemia : the ODYSSEY open-label extension study 

  Blom, Dirk J.; Breedt, Johannes; Burgess, Lesley J.; Ebrahim, Iftikhar O.; Soma, Prashilla; Van der Walt, Eugene; Naidoo, Poobalan; Van Tonder, Alet; Raal, Frederick J. (Clinics Cardive, 2019-09-21)

  BACKGROUND : Alirocumab reduces low-density lipoprotein cholesterol (LDL-C) levels by up to 61%. The ODYSSEY Open-Label Extension study investigated the effect of alirocumab in patients with heterozygous familial ...
• Dietary habits and the association of neopterin with niacin and tryptophan in university students 

  Fouché, Tanya (University of Pretoria, 2019)

  Background: University students are potentially nutrient compromised as a result of social (demographics, socio-economic status) and other factors (such as transitioning from school to university - independent living). ...
• Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease 

  Pretorius, Etheresia; Page, Martin J.; Mbotwe, Sthembile; Kell, Douglas B. (Public Library of Science, 2018-03-01)

  The thrombin-induced polymerisation of fibrinogen to form fibrin is well established as a late stage of blood clotting. It is known that Parkinson's Disease (PD) is accompanied by dysregulation in blood clotting, but it ...
• The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma 

  Boyd, Laura Susan; Gozuacik, Devrim; Joubert, Anna Margaretha (BioMed Central, 2018)

  BACKGROUND: The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against ...
• Oncosuppressors and oncogenes : role in haemangioma genesis and potential for therapeutic targeting 

  Mabeta, Peaceful Lucy (MDPI, 2018-04)

  Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. ...
• An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles 

  Stander, Barend Andre; Van Vollenstee, Fiona A.; Kallmeyer, Karlien; Potgieter, Marnie; Joubert, Annie M.; Swanepoel, Andri; Kotze, Lara; Moolman, Sean; Pepper, Michael Sean (Public Library of Science, 2018-07-03)

  The field of dermal fillers is evolving rapidly and numerous products are currently on the market. Biodegradable polymers such as polycaprolactone (PCL) have been found to be compatible with several body tissues, and ...
• Warburg effect and its role in tumourigenesis 

  Lebelo, M.T. (Maphuti); Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (Springer, 2019-10)

  Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and ...
• Effects of glutamine deprivation on oxidative stress and cell survival in breast cell lines 

  Gwangwa, Mokgadi Violet; Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (BioMed Central, 2019-03-27)

  BACKGROUND : Tumourigenic cells modify metabolic pathways in order to facilitate increased proliferation and cell survival resulting in glucose- and glutamine addiction. Previous research indicated that glutamine deprivation ...
• Medial amygdala Kiss1 neurons mediate female pheromone stimulation of luteinizing hormone in male mice 

  Aggarwal, Sanya; Tang, Celion; Sing, Kristen; Kim, Hyun Wook; Millar, Robert P.; Tello, Javier A. (Karger, 2019)

  BACKGROUND/AIMS : The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. ...
• Comparison of structures and cytotoxicity of mupirocin and batumin against melanoma and several other cancer cell lines 

  Reva, Oleg N.; Rademan, Sunelle; Visagie, M.H. (Michelle Helen); Lebelo, M.T. (Maphuti); Gwangwa, Mokgadi Violet; Klochko, Vitalii V.; Joubert, Anna Margaretha; Lall, Namrita (Future Science, 2019)

  AIM : To determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. MATERIALS AND METHODS : Molecular docking, cytotoxicity ...
• Activation of PPARs modulates signalling pathways and expression of regulatory genes in osteoclasts derived from human CD14+ monocytes 

  Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (MDPI Publishing, 2019-04-11)

  Osteoclasts are the sole bone resorbing cell in the body and their over activity is key in the development of osteoporosis. Osteoclastogenesis is mediated by receptor activator of nuclear factor B ligand (RANKL) signalling ...
• The morphological and physiological effects of a low-carbohydrate high-fat diet on coagulation parameters 

  Jobela, Babalwa Cynthia (University of Pretoria, 2019)

  The contribution of unhealthy diets to the emergence of chronic diseases which are a burden to both the society and health care costs, greatly increased over the last decades. Starch and sugar have been linked to the ...

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