• Effects of a 6-month exercise programme on disease activity, physical and functional parameters in patients with ankylosing spondylitis : randomised controlled trial 

  Nolte, Kim; Janse van Rensburg, Dina Christina; Fletcher, Lizelle (OASIS, 2021-06)

  BACKGROUND : Respiratory morbidity is common in children with neuromuscular diseases (NMD) owing to chronic hypoventilation and impaired cough. Optimal, cost-effective respiratory management requires implementation of ...
• The effect of infraslow frequency neurofeedback on autonomic nervous system function in adults with anxiety and related diseases 

  Balt, Karlien; Du Toit, Peet J.; Smith, Mark; Janse van Rensburg, Charl (International Society for Neurofeedback & Research, 2020-06)

  Peripheral body monitoring of autonomic nervous system (ANS) response has been routinely applied during infraslow fluctuation (ISF) neurofeedback training. This study hypothesized that ISF training has a distinct physiological ...
• Potential protective effects of neonatal supplementation with oleanolic acid on peroxisome proliferator-activated receptor gamma (PPARγ)-ligand dependent regulation of glucose homeostasis in high fructose-fed rats 

  Mosana, Mmahiine; Ayeleso, Ademola; Nyakudya, Trevor Tapiwa; Erlwanger, Kennedy; Mukwevho, Emmanuel (Natural Product, 2020)

  The effect of neonatal oral supplementation of oleanolic acid (OA) on peroxisome proliferator-activated receptor gamma (PPARγ)-1 on glucose homeostasis in high fructose-fed rats was investigated. Rat pups (7 days old) ...
• Sunitinib malate inhibits hemangioma cell growth and migration by suppressing focal adhesion kinase signaling 

  Scholtz, Wihan; Mabeta, Peaceful Lucy (University of South Bohemia in České Budějovice, 2020-12-07)

  Sunitinib malate is a small molecule that targets multiple receptor tyrosine kinases and blocks their activity. Receptors targeted by sunitinib are implicated in tumor vascularization and are overexpressed by vascular ...
• An overview of the potential use of ethno-medicinal plants targeting the Renin–Angiotensin system in the treatment of hypertension 

  De Lange-Jacobs, Pietro; Shaikh-Kader, Asma; Thomas, Bianca; Nyakudya, Trevor Tapiwa (MDPI Publishing, 2020-04-30)

  The development of risk factors associated with cardiovascular disorders present a major public health challenge in both developed countries and countries with emerging economies. Hypertension and associated complications ...
• The potential therapeutic value of medicinal plants in the management of metabolic disorders 

  Nyakudya, Trevor Tapiwa; Tshabalala, Thulani; Dangarembizi, Rachael; Erlwanger, Kennedy H.; Ndhlala, Ashwell R. (MDPI Publishing, 2020-06-09)

  Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is associated with an increased risk of developing diabetes and other major cardiovascular complications. The rise in the global prevalence ...
• Serum metabolome changes in relation to prothrombotic state induced by combined oral contraceptives with drospirenone and ethinylestradiol 

  Swanepoel, A.C. (Albe Carina); Bester, Janette; Emmerson, Odette; Soma, Prashilla; Beukes, Derylize; Van Reenen, Mari; Loots, Du Toit; Du Preez, Ilse (Mary Ann Liebert, 2020-07)

  The association between hypercoagulability and use of drospirenone (DRSP) and ethinylestradiol (EE) containing combined oral contraceptives (COCs) is an important clinical concern. We have previously reported that the ...
• Willingness of people with Type 2 diabetes to start insulin therapy : evidence from the South African Tshwane Insulin Project (TIP) 

  Ngassa Piotie, Patrick; Wood, Paola Silvia; Webb, Elizabeth M.; Marcus, Tessa S.; Rheeder, Paul (Elsevier, 2020-10)

  AIMS : To determine factors associated with ‘hypothetical willingness’ to start insulin among people with Type 2 diabetes (T2DM). METHODS : A quantitative cross-sectional study with insulin-naïve T2DM patients at 23 primary ...
• Early‐life exposure to alcohol and the risk of alcohol‐induced liver disease in adulthood 

  Asiedu, Bernice; Nyakudya, Trevor Tapiwa; Lembede, Busisani Wiseman; Chivandi, Eliton (Wiley, 2021-04)

  Alcohol consumption remains prevalent among pregnant and nursing mothers despite the well‐documented adverse effects this may have on the offspring. Moderate‐to‐high levels of alcohol consumption in pregnancy result in ...
• Evaluation of a strategy based on multi-drug targeting of cancer proteins in breast cancer cell lines 

  Nortje, Evangeline (University of Pretoria, 2020)

  Therapeutic inefficacy of conventional cancer treatment is a particular dilemma associated with metastatic triple negative breast cancer (TNBC), with patients still facing poor prognosis. The design and development of novel ...
• Comparison of pathological clotting using haematological, functional and morphological investigations in HIV‑positive and HIV‑negative patients with deep vein thrombosis 

  Jackson, Brandon Spencer; Goncalves, Julien Nunes; Pretorius, Etheresia (BioMed Central, 2020-06-22)

  BACKGROUND : Patients infected with the human immunodeficiency virus (HIV) are more prone to systemic inflammation and pathological clotting, and many may develop deep vein thrombosis (DVT) as a result of this ...
• In vitro induction of the apoptotic intrinsic pathway via a new antimitotic agent 

  Wolmarans, Elize (University of Pretoria, 2014)

  Unique, in silico-designed compounds with possible anticancer properties were identified in our laboratory. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16), with potential carbonic anhydrase IX inhibiting activity, ...
• Understanding the basics of cannabidiol from cannabis to apply to therapeutics in epilepsy 

  Hay, Leon (Health and Medical Publishing Group, 2020-02)

  The compounds present in cannabis have been in use for both recreational and medicinal purposes for many centuries. Changes in the legislation in South Africa have led to an increase in the number of people interested in ...
• Administration of S-allyl cysteine to neonatal rats modulates inflammatory biomarkers in high-fructose-fed rats in adulthood 

  Ayeleso, Ademola O.; Lembede, Busisani W.; Nyakudya, Trevor Tapiwa; Adepoju, Ayodeji E.; Chegou, Novel N.; Mukwevho, Emmanuel (Pharmacotherapy Group, 2020-05)

  PURPOSE : To investigate the potential prophylactic effect of S-allyl cysteine (SAC), found in garlic (Allium sativum), against the development of apro-inflammatory status induced by diet in neonatal rats later on in ...
• Binding pose analysis of hydroxyethylamine based β-secretase inhibitors and application thereof to the design and synthesis of novel indeno[1,2-b]indole based inhibitors 

  Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)

  β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
• In vitro quantification : long-term effect of glucose deprivation on various cancer cell lines 

  Mathews, Edward Henry; Visagie, M.H. (Michelle Helen); Meyer, Albertus Abram; Joubert, Anna Margaretha; Mathews, George Edward (Elsevier, 2020-06)

  OBJECTIVE : Although metabolic treatment of highly glycolytic cancers and metastases is becoming an important research field, the effects of such treatments are not fully quantified yet. In this article we attempt to ...
• Sulphamoylated estradiol analogue induces reactive oxygen species generation to exert its antiproliferative activity in breast cancer cell lines 

  Lebelo, M.T. (Maphuti); Joubert, Anna Margaretha; Visagie, M.H. (Michelle Helen) (MDPI, 2020-09)

  2-Methoxyestradiol (2ME), a 17β-estradiol metabolite, exerts anticancer properties in vitro and in vivo. To address 2ME’s low bioavailability, research led to the in silico design of sulphamoylated 2ME analogues. However, ...
• Ultrastructural alterations of whole blood by copper, manganese and mercury metal mixtures using a chronic in vivo model of coagulation 

  Janse van Rensburg, Maxine; Van Rooy, Mia-Jeanne; Bester, Megan Jean; Oberholzer, Hester Magdalena (Elsevier, 2020-04)

  Globally, contamination of drinking water by heavy metals is increasing and poses a potential hazard to human health. Data on heavy metal mixtures and their effects on thrombosis are limited. The objective of this study ...
• Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro 

  Sagar, Travers; Kasonga, Abe E.; Baschant, Ulrike; Rauner, Martina; Moosa, Shaakirah; Marais, Sumari; Kruger, Marlena C.; Coetzee, Magdalena (Elsevier, 2020-01)

  Bone remodelling in a healthy body is in constant balance, maintaining an adaptive and robust skeletal system. In osteoporosis this balance is disrupted with the rates of osteoclastic bone resorption exceeding osteoblastic bone ...
• Epidemiology, clinical characteristics and severity of gradual onset injuries in recreational road cyclists : a cross-sectional study in 21,824 cyclists - SAFER XIII 

  Du Toit, Francois; Schwellnus, Martin Peter; Wood, Paola Silvia; Swanevelder, Sonja; Killops, Jannelene; Jordaan, Esme (Elsevier, 2020-11)

  OBJECTIVES : Prevalence, clinical characteristics and severity of gradual onset injuries (GOIs) in cyclists are poorly documented. We determine the prevalence, anatomical regions/sites affected and severity of GOIs among ...

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