• Comparison of structures and cytotoxicity of mupirocin and batumin against melanoma and several other cancer cell lines 

  Reva, Oleg N.; Rademan, Sunelle; Visagie, M.H. (Michelle Helen); Lebelo, M.T. (Maphuti); Gwangwa, Mokgadi Violet; Klochko, Vitalii V.; Joubert, Anna Margaretha; Lall, Namrita (Future Science, 2019)

  AIM : To determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. MATERIALS AND METHODS : Molecular docking, cytotoxicity ...
• Activation of PPARs modulates signalling pathways and expression of regulatory genes in osteoclasts derived from human CD14+ monocytes 

  Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (MDPI Publishing, 2019-04-11)

  Osteoclasts are the sole bone resorbing cell in the body and their over activity is key in the development of osteoporosis. Osteoclastogenesis is mediated by receptor activator of nuclear factor B ligand (RANKL) signalling ...
• A novel non‑sulphamoylated 2‑methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions 

  Botes, Mandie; Jurgens, Tamarin; Riahi, Zohreh; Visagie, M.H. (Michelle Helen); Janse van Vuuren, Rustelle; Joubert, Annie M.; Van den Bout, Jan Iman (BioMed Central, 2018-11-19)

  BACKGROUND : 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. ...
• In vitro effects of arachidonic acid and docosahexaenoic acid on osteoclastogenesis and bone resorption in human CD14+ monocytes 

  Kasonga, Abe E. (University of Pretoria, 2015)

  Bone remodelling is a continuous physiological process in the body mediated by bone resorbing osteoclasts and bone forming osteoblasts. Osteoclasts are multinucleated cells formed by the fusion of haematopoietic cells ...
• In vitro study of in silico designed sirtuin 1 and bromodomain 4 inhibitors on human neuroblastoma SH-SY5Y and acute myeloid leukemia U937 cells 

  Otto, Monique (University of Pretoria, 2019)

  In this novel study, the effects of newly in silico designed bromodomain 4 and sirtuin 1 inhibitors on cellular growth and death was investigated in the neuroblastoma SH-SY5Y and acute myeloid leukemia U937 cell lines. The ...
• HFOB 1.19 osteoblast cells grown on a biomimetic biphasic nanoscaffold : an in vitro evaluation for possible bone tissue engineering 

  Du Preez, Ilse; Richter, Wim; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Joubert, Annie M. (Allied Academies, 2018)

  Much research over the past five decades has focussed on the repair and replacement of bone. Recently, the research focus has shifted to nanotechnology since it provides a platform from which to alter and possibly improve ...
• Confirming oral bioavailability of novel oestradiol analogues by liquid chromatography-tandem mass spectrometry in a murine model 

  Mothibeli, K.T.; Mercier, Anne Elisabeth; Cromarty, Allan Duncan; Rheeder, M.; Naidoo, Vinny; Olorunju, S.A.S.; Joubert, Anna Margaretha (Allied Academies, 2018)

  2-methoxyestradiol (2ME) is an endogenous 17β-oestradiol metabolite that exerts antiproliferative, antiangiogenic and antitumour activity on cancer cells both in vitro and in vivo. However, the use of 2ME as a potential ...
• Oxidative and haemostatic effects of copper, manganese and mercury, alone and in combination at physiologically relevant levels: an ex vivo study 

  Van Rensburg, M.J.; Van Rooy, Mia-Jeanne; Bester, Megan Jean; Serem, June Cheptoo; Venter, Chantelle; Oberholzer, Hester Magdalena (Sage, 2018)

  Water contamination with metals due to anthropogenic activity is increasing and subsequent exposure increases the risk of associated toxicity. Exposure is not limited to a single metal but usually involves mixtures of ...
• Free fatty acid receptor 4-β-arrestin 2 pathway mediates the effects of different classes of unsaturated fatty acids in osteoclasts and osteoblasts 

  Kasonga, Abe E.; Kruger, Marlena C.; Coetzee, Magdalena (Elsevier, 2019-03)

  Bone is a dynamic tissue that is constantly remodelled by bone resorbing osteoclasts and bone forming osteoblasts, respectively. A breakdown in the remodelling process underlies several bone diseases such as osteoporosis. ...
• Cancer stem cells in head and neck carcinomas : identification and possible therapeutic implications 

  Wolmarans, Elize; Boy, S.C. (Sonja); Nel, Sulette; Mercier, Anne Elisabeth; Pepper, Michael Sean (Springer, 2017-11)

  The recurrence and/or lack of response of certain tumors to radio- and chemotherapy has been attributed to a small subpopulation of cells termed cancer stem cells (CSCs). CSCs have been identified in many tumors (including ...
• Exposure of breast and lung cancer cells to a novel estrone analog prior to radiation enhances Bcl-2-mediated cell death 

  Nolte, Elsie M.; Joubert, Annie M.; Lakier, Roy; Van Rensburg, Ado; Mercier, Anne Elisabeth (MDPI Publishing, 2018)

  Following exposure of cells to gamma-radiation, a cascade of intracellular consequences may be observed in a semitemporal manner. This includes deoxyribonucleic acid (DNA) damage and reactive oxygen species (ROS) ...
• Evaluation of the neurotoxicity of pentachlorophenol and its active metabolites on SH-SY5Y neuroblastoma cells 

  Fraser, Desiree Linda (University of Pretoria, 2018)

  Pentachlorophenol (PCP) is an organochloride pesticide that is ubiquitous within the environment due to its chemical stability. It is classified as a persistent organic pollutant, and has been predominantly used in the ...
• Electron confocal and atomic force microscopic analysis of platelets fibrin and erythrocytes in atopic asthma 

  Alummoottil, Sajee (University of Pretoria, 2018)

  Background: The underlying risk factor of non-communicable diseases is inflammation. The pathophysiology of asthma and/or allergic asthma is also, no surprisingly, also linked to chronic inflammation. The prevalence and ...
• Reliability of baseline concussion test results in youth athletes from two consecutive sport seasons 

  Coetzer, Jeanette (University of Pretoria, 2018)

  Background: Concussion is a common injury reported in high velocity or contact sport, and a large amount of controversy regarding set protocols for proper management still remains. However, neuropsychological testing, done ...
• Aetiological doctrines and prevalence of pellagra : 18th century to middle 20th century 

  Viljoen, Margaretha; Bipath, Priyesh; Roos, J.L. (Johannes Louw) (AOSIS, 2018-09-11)

  Pellagra is characterised by dermatological, gastrointestinal and neuropsychiatric manifestations. Millions contracted the disease and hundreds of thousands died between the time it was first recorded until pellagra was ...
• Aspartame : should individuals with Type II diabetes be taking it? 

  Choudhary, Arbind Kumar (Bentham Science, 2018)

  BACKGROUND : Individuals with Type II Diabetes (T2D) have to manage blood glucose levels to sustain health and longevity. Artificial sweeteners (including aspartame) are suggested sugar alternatives for these individuals. ...
• The potential of LPS-binding protein to reverse amyloid formation in plasma fibrin of individuals with Alzheimer-type dementia 

  Pretorius, Etheresia; Bester, Janette; Page, Martin J.; Kell, Douglas B. (Frontiers Media, 2018-08-22)

  Many studies indicate that there is a (mainly dormant) microbial component in the progressive development of Alzheimer-type dementias (ADs); and that in the case of Gram-negative organisms, a chief culprit might be the ...
• Insights into the mechanism of antiproliferative effects of primaquine-cinnamic acid conjugates on MCF-7 cells 

  Mabeta, Peaceful Lucy; Pavic, Kristina; Zorc, Branka (De Gruyter Open, 2018-09)

  In our previous paper, we showed that three primaquine-cinnamic acid conjugates composed of primaquine (PQ) residue and cinnamic acid derivatives (CADs) bound directly by an amide linkage (1) or through an acylsemicarbazide ...
• Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines 

  Nel, Marcel; Joubert, Anna Margaretha; Dohle, Wolfgang; Potter, Barry V.L.; Theron, A.E. (Anne Elisabeth) (Dove Medical Press, 2018)

  BACKGROUND : A and B rings of the steroidal microtubule disruptor, 2-methoxyestradiol, and its analogs can be mimicked with a tetrahydroisoquinoline (THIQ) core. THIQs are cytotoxic agents with potential anticancer activities. ...
• Promising anticancer activity of batumin : a natural polyene antibiotic produced by Pseudomonas batumici 

  Soldatkina, Maria.A.; Klochko, Vitalii V.; Zagorodnya, Svitlana D.; Rademan, Sunelle; Visagie, M.H. (Michelle Helen); Lebelo, M.T. (Maphuti); Gwangwa, Mokgadi Violet; Joubert, Anna Margaretha; Lall, Namrita; Reva, Oleg N. (Future Science, 2018-09)

  AIM : To determine the computer-predicted anticancer activity of antibiotic batumin. MATERIALS AND METHODS : Cytotoxicity assays, cell morphology microscopy and cell cycle progression were studied in cancer and nontumorigenic ...

View more